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Immunology

D-Index
73
Citations
26197
World Ranking
2096
National Ranking
81

Overview

Jean-Louis Mege is affiliated with Aix-Marseille University in France. Their research focuses primarily on medicine, immunology, and microbiology, with considerable contributions to infectious diseases and immunology subfields. Their work spans topics including COVID-19 clinical research studies, SARS-CoV-2 and COVID-19 research, long-term effects of COVID-19, vector-borne infectious diseases, circadian rhythm and melatonin, systemic lupus erythematosus research, and COVID-19 impact on reproduction.

The scientist has published extensively in several key venues, notably:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medical Virology
  • The Journal of Infectious Diseases
  • International Journal of Molecular Sciences

Some recent representative publications include:

  • Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis, 2021, The Journal of Infectious Diseases
  • Natural history of COVID-19 and therapeutic options, 2020, Expert Review of Clinical Immunology
  • Sexual Dimorphism and Gender in Infectious Diseases, 2021, Frontiers in Immunology
  • Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients, 2021, Frontiers in Immunology
  • A Tangled Threesome: Circadian Rhythm, Body Temperature Variations, and the Immune System, 2021, Biology

The researcher has collaborated frequently with several co-authors, including:

  • Soraya Mezouar
  • Bernard La Scola
  • Laëtitia Gay
  • Joana Vitte
  • Christian Devaux

In addition to journal articles, Jean-Louis Mege has contributed to book publications such as:

  • Tissue Remodeling in Health and Disease Caused by Bacteria, Parasites, Fungi, and Viruses, Frontiers Media, 2021
  • Macrophages, IntechOpen, 2020

The scope and volume of their work reflect a multidisciplinary approach within medical sciences, emphasizing both clinical research and immunological mechanisms related to infectious diseases.

Best Publications

  • Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

    Peter J Murray;Judith E Allen;Subhra K Biswas;Edward A Fisher

  • Macrophage Polarization in Bacterial Infections

    Marie Benoit;Benoît Desnues;Jean-Louis Mege

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma.

    Claude Martin;Christophe Boisson;Martine Haccoun;Laurent Thomachot

  • The two faces of interleukin 10 in human infectious diseases

    Jean-Louis Mege;Soraya Meghari;Amélie Honstettre;Christian Capo

  • Virulent Brucella abortus Prevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments

    Javier Pizarro-Cerdá;Edgardo Moreno;Veronique Sanguedolce;Jean-Louis Mege

  • Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma

    Valéry Combes;Terrie E. Taylor;Irène Juhan-Vague;Jean Louis Mège

  • Ameobal Pathogen Mimivirus Infects Macrophages through Phagocytosis

    Eric Ghigo;Jürgen Kartenbeck;Pham Thi Kim Lien;Lucas Pelkmans

  • Effect of Sex on Coxiella burnetii Infection: Protective Role of 17β-Estradiol

    Marc Leone;Amélie Honstettre;Hubert Lepidi;Christian Capo

  • Coxiella burnetii survival in THP-1 monocytes involves the impairment of phagosome maturation: IFN-gamma mediates its restoration and bacterial killing.

    Eric Ghigo;Christian Capo;Ching-Hsuan Tung;Didier Raoult

  • Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis.

    Asma Boumaza;Soraya Mezouar;Eloïne Bestion

  • Macrophage polarization and bacterial infections.

    Jean-Louis Mège;Vikram Mehraj;Christian Capo

  • IFN-gamma-mediated control of Coxiella burnetii survival in monocytes: the role of cell apoptosis and TNF.

    Jérôme Dellacasagrande;Christian Capo;Didier Raoult;Jean-Louis Mege

  • Subversion of monocyte functions by coxiella burnetii: impairment of the cross-talk between alphavbeta3 integrin and CR3.

    Christian Capo;Frederik P. Lindberg;Sonia Meconi;Yona Zaffran

  • Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4

    Amélie Honstettre;Eric Ghigo;Alix Moynault;Christian Capo

  • Parachlamydia acanthamoeba Enters and Multiplies within Human Macrophages and Induces Their Apoptosis

    Gilbert Greub;Jean-Louis Mege;Didier Raoult

  • Sexual Dimorphism and Gender in Infectious Diseases.

    Cléa Melenotte;Ines Lakbar;Soraya Mezouar

  • Coxiella burnetii, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages.

    Marie Benoit;Bernadette Barbarat;Alain Bernard;Daniel Olive

  • Early postoperative compensatory anti-inflammatory response syndrome is associated with septic complications after major surgical trauma in patients with cancer

    Unknown

  • Blood leukocytes and macrophages of various phenotypes have distinct abilities to form podosomes and to migrate in 3D environments

    Céline Cougoule;Céline Cougoule;Emeline Van Goethem;Emeline Van Goethem;Véronique Le Cabec;Véronique Le Cabec;Fanny Lafouresse;Fanny Lafouresse;Fanny Lafouresse

  • Dysregulation of Cytokines in Acute Q Fever: Role of Interleukin-10 and Tumor Necrosis Factor in Chronic Evolution of Q Fever

    Amélie Honstettre;Guenièvre Imbert;Eric Ghigo;Frédérique Gouriet

  • Natural history of COVID-19 and therapeutic options.

    Philippe Gautret;Matthieu Million;Pierre-André Jarrot;Laurence Camoin-Jau

Frequent Co-Authors

Christian Capo
Christian Capo Aix-Marseille University
Didier Raoult
Didier Raoult Aix-Marseille University
Pierre Bongrand
Pierre Bongrand Aix-Marseille University
Marc Leone
Marc Leone Aix-Marseille University
Hubert Lepidi
Hubert Lepidi Aix-Marseille University
Jean-Pierre Gorvel
Jean-Pierre Gorvel Aix-Marseille University
Daniel Olive
Daniel Olive Aix-Marseille University
Christian Devaux
Christian Devaux Centre national de la recherche scientifique, CNRS
Claude Martin
Claude Martin Nord University
Isabelle Maridonneau-Parini
Isabelle Maridonneau-Parini Federal University of Toulouse Midi-Pyrénées

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