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Gerard J. Mulder

Gerard J. Mulder

D-Index & Metrics

Chemistry

D-Index
48
Citations
5925
World Ranking
15446
National Ranking
277

Overview

Gerard J. Mulder is affiliated with Leiden University in the Netherlands. Their research primarily focuses on the fields of Pharmacology, Toxicology, and Pharmaceutics. Within these disciplines, their work spans key subfields such as Pharmacology and Oncology.

The scientist's research interests include the study of Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, and Drug-Induced Hepatotoxicity and Protection.

Mulder's recent scholarly contributions include two papers published between 2024 and 2025. The first paper, published in 2024 in the journal Drug Metabolism and Disposition, is titled "After 50 Years of Hepatic Clearance Models, Where Should We Go from Here? Improvements and Implications for Physiologically Based Pharmacokinetic Modeling." The second paper, titled "Selection of liver models of hepatic drug clearance: Improvements and implications for ivive and PBPK modeling," was published in 2025 in Drug Metabolism and Pharmacokinetics.

These two publications reflect research in modeling hepatic clearance, with an emphasis on improving physiologically based pharmacokinetic (PBPK) methods.

Frequent collaborators include K. Sandy Pang and Weijia Ivy Lu, each of whom has worked alongside Mulder in two publications.

Mulder's work has appeared predominantly in the following scientific journals:

  • Drug Metabolism and Disposition
  • Drug Metabolism and Pharmacokinetics

The research contributions focus on understanding drug metabolism processes, mechanisms of drug resistance, and hepatotoxicity, contributing to pharmacological and toxicological sciences.

Best Publications

  • Glucuronidation and its Role in Regulation of Biological Activity of Drugs

    Gerard J. Mulder

  • Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-l-methyl-6-phenyUmidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues

    Keith R. Kaderlik;Rodney F. Minchin;Gerard J. Mulder;Kenneth F. Ilett

  • Generation of reactive metabolites of N-hydroxy-phenacetin by glucuronidation and sulfation

    Gerard J. Mulder;Jack A. Hinson;James R. Gillette

  • The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and gamma-glutamyl domains.

    A E P Adang;J Brussee;A van der Gen;G J Mulder

  • Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine

    B. Van De Water;J. P. Zoeteweij;H. J. G. M. De Bont;G. J. Mulder

  • Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells.

    Merei Huigsloot;Ine B. Tijdens;Gerard J. Mulder;Bob van de Water

  • Sulfation of Drugs and Related Compounds

    Unknown

  • Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes

    K R Kaderlik;G J Mulder;R J Turesky;N P Lang

  • Formation and identification of glutathione conjugates from 2-nitrosofluorene and N-hydroxy-2-aminofluorene

    G.J. Mulder;L.E. Unruh;F.E. Evans;B. Ketterer

  • Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro.

    Kruidering M;van de Water B;Zhan Y;Baelde Jj

  • Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance.

    Danny Burg;Gerard J. Mulder

  • Peptidomimetic Glutathione Analogues as Novel γGT Stable GST Inhibitors

    Danny Burg;Dmitri V Filippov;Ralph Hermanns;Gijs A van der Marel

  • Cleavage of the Actin-capping Protein α-Adducin at Asp-Asp-Ser-Asp633-Ala by Caspase-3 Is Preceded by Its Phosphorylation on Serine 726 in Cisplatin-induced Apoptosis of Renal Epithelial Cells

    Bob van de Water;Ine B. Tijdens;Annelies Verbrugge;Merei Huigsloot

  • Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines

    Gerard J. Mulder;John H. N. Meerman

  • Role of sulfation in the formation of DNA adducts from N-hydroxy-2-acetylaminofluorene in rat liver in vivo . Inhibition of N-acetylated aminofluorene adduct formation by penta-chlorophenol

    J.H.N. Meerman;F.A. Beland;G.J. Mulder

  • Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism, PhIP-DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes

    Keith R. Kaderlik;Gerard J. Mulder;Joseph G. Shaddock;Daniel A. Casciano

  • Modulation of glutathione conjugation in vivo: how to decrease glutathione conjugation in vivo or in intact cellular systems in vitro.

    Gerard J Mulder;Sivi Ouwerkerk-Mahadevan

  • Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells: studies on involvement of adenosine receptors and adenosine uptake.

    S.Mariette Schrier;Erica W van Tilburg;Hans van der Meulen;Ad P Ijzerman

  • Conversion of the N-O-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates

    Gerard J. Mulder;Jack A. Hinson;James R. Gillette

  • Renal proximal tubular cells in suspension or in primary culture as in vitro models to study nephrotoxicity

    P J Boogaard;J F Nagelkerke;G J Mulder

  • The role of metallothionein in the reduction of cisplatin-induced nephrotoxicity by Bi3(+)-pretreatment in the rat in vivo and in vitro. Are antioxidant properties of metallothionein more relevant than platinum binding?

    Pieter J. Boogaard;Anja Slikkerveer;J.Fred Nagelkerke;Gerard J. Mulder

  • Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium.

    J. P. Zoeteweij;B. Van De Water;H. J. G. M. De Bont;G. J. Mulder

  • Hepatotoxicity of tetrahydroaminoacridine in isolated rat hepatocytes: effect of glutathione and vitamin E.

    Peter Dogterom;J.Fred Nagelkerke;Gerard J. Mulder

  • Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities

    Wolfgang W. Huber;Candee H. Teitel;Brian F. Coles;Roberta S. King

Frequent Co-Authors

Johannes Brussee
Johannes Brussee Leiden University
G. A. Van Der Marel
G. A. Van Der Marel Leiden University
J. H. Van Boom
J. H. Van Boom Leiden University
Douwe D. Breimer
Douwe D. Breimer Leiden University
Bob van de Water
Bob van de Water Leiden University
Cornelis J.H. van de Velde
Cornelis J.H. van de Velde Leiden University Medical Center
Jos H. Beijnen
Jos H. Beijnen Utrecht University
Geert-Jan Boons
Geert-Jan Boons University of Georgia
Dirk K. F. Meijer
Dirk K. F. Meijer University of Groningen
Fred F. Kadlubar
Fred F. Kadlubar United States Food and Drug Administration

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