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Chemistry

D-Index
55
Citations
14021
World Ranking
11982
National Ranking
3217

Overview

Evan T. Powers is affiliated with the Scripps Research Institute in the United States. Their research spans several fields within biology and medicine, with a focus on biochemical and molecular biological processes related to disease mechanisms.

The main fields of study covered by their work include Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader fields, their subfields of study are Molecular Biology, Cell Biology, Physiology, Epidemiology, and Genetics.

The topics frequently addressed by their research encompass a range of biological and medical concerns:

  • Endoplasmic Reticulum Stress and Disease
  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Autophagy in Disease and Therapy
  • Genomics, phytochemicals, and oxidative stress
  • Retinal Development and Disorders
  • Protein Kinase Regulation and GTPase Signaling

Evan T. Powers has contributed to publications in a number of scientific venues. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Amyloid
  • Cardiology and Therapy
  • Nature Chemical Biology
  • Nature Communications

Their recent papers demonstrate a focus on cellular stress responses, protein homeostasis, and cellular remodeling mechanisms. Selected recent publications are:

  • "Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming," 2020, Nature Chemical Biology
  • "Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity," 2022, Nature Communications
  • "Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3," 2020, Antioxidants
  • "ATF6 is essential for human cone photoreceptor development," 2021, Proceedings of the National Academy of Sciences
  • "Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma," 2020, Amyloid

Frequent collaborators include:

  • Jeffery W. Kelly
  • R. Luke Wiseman
  • Julia M. D. Grandjean
  • Gabriel M. Kline
  • Karina Nugroho

Best Publications

  • Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

    Evan T. Powers;Richard I. Morimoto;Andrew Dillin;Jeffery W. Kelly

  • Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

    Christine E. Bulawa;Stephen Connelly;Michael DeVit;Lan Wang

  • Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

    Maria Talantova;Sara Sanz-Blasco;Xiaofei Zhang;Peng Xia

  • Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics

    Per Hammarström;R. Luke Wiseman;Evan T. Powers;Jeffery W. Kelly

  • Targeting protein aggregation for the treatment of degenerative diseases.

    Yvonne S. Eisele;Cecilia Monteiro;Colleen Fearns;Sandra E. Encalada

  • Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

    Jiyong Lee;Elizabeth K Culyba;Evan T Powers;Jeffery W Kelly

  • Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity.

    Per Hammarström;Xin Jiang;Amy R Hurshman;Evan T Powers

  • Transthyretin aggregation under partially denaturing conditions is a downhill polymerization.

    Amy R Hurshman;Joleen T White;Evan T Powers;Jeffery W Kelly

  • Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.

    Daryl A Bosco;Douglas M Fowler;Qinghai Zhang;Jorge Nieva

  • The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.

    Steven M. Johnson;Stephen Connelly;Colleen Fearns;Evan T. Powers

  • Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics

    Songpon Deechongkit;Houbi Nguyen;Evan T. Powers;Philip E. Dawson

  • "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.

    David E. Mortenson;Gabriel J. Brighty;Lars Plate;Grant Bare

  • Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action†

    Hossein Razavi;Satheesh K. Palaninathan;Evan T. Powers;R. Luke Wiseman

  • Diversity in the origins of proteostasis networks--a driver for protein function in evolution.

    Evan T. Powers;William E. Balch

  • Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

    Wentao Chen;Jiajia Dong;Lars Plate;David E. Mortenson

  • The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability

    Sarah R. Hanson;Elizabeth K. Culyba;Tsui-Ling Hsu;Chi-Huey Wong

  • ALS Mutants of Human Superoxide Dismutase Form Fibrous Aggregates Via Framework Destabilization

    Michael DiDonato;Lisa Craig;Mary E. Huff;Maria M. Thayer

  • Metabolite-initiated protein misfolding may trigger Alzheimer's disease

    Qinghai Zhang;Evan T. Powers;Jorge Nieva;Mary E. Huff

  • The Kinetics of Nucleated Polymerizations at High Concentrations: Amyloid Fibril Formation Near and Above the “Supercritical Concentration”

    Evan T. Powers;David L. Powers

  • Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.

    Jianmin Gao;Daryl A Bosco;Evan T Powers;Jeffery W Kelly

  • Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

    Lars Plate;Christina B Cooley;John J Chen;Ryan J Paxman

Frequent Co-Authors

Jeffery W. Kelly
Jeffery W. Kelly Scripps Research Institute
Ian A. Wilson
Ian A. Wilson Scripps Research Institute
William E. Balch
William E. Balch Scripps Health
Chi-Huey Wong
Chi-Huey Wong Scripps Research Institute
Martin Gruebele
Martin Gruebele University of Illinois at Urbana-Champaign
Richard A. Lerner
Richard A. Lerner Scripps Research Institute
Richard I. Morimoto
Richard I. Morimoto Northwestern University
Lila M. Gierasch
Lila M. Gierasch University of Massachusetts Amherst
Benjamin F. Cravatt
Benjamin F. Cravatt Scripps Research Institute
Jerrold Meinwald
Jerrold Meinwald Cornell University

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