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Catharien M. U. Hilkens

Catharien M. U. Hilkens

D-Index & Metrics

Immunology

D-Index
54
Citations
13723
World Ranking
3860
National Ranking
338

Overview

Catharien M. U. Hilkens is affiliated with Newcastle University in the United Kingdom and has a research focus primarily in Medicine, with substantial contributions to Immunology and Microbiology. Their work spans various subfields including Immunology, Rheumatology, Biomedical Engineering, Molecular Biology, and Oncology.

The scientist's research topics cover a diverse set of areas, with particular emphasis on:

  • Immunotherapy and Immune Responses
  • Rheumatoid Arthritis Research and Therapies
  • Systemic Lupus Erythematosus Research
  • Monoclonal and Polyclonal Antibodies Research
  • 3D Printing in Biomedical Research
  • T-cell and B-cell Immunology
  • Cell Adhesion Molecules Research

Catharien M. U. Hilkens has published extensively in several scientific venues. The most frequent publication sources include:

  • Annals of the Rheumatic Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Polymers
  • SSRN Electronic Journal

Recent notable papers authored or co-authored by Hilkens include:

  • "Synovial Macrophages in Osteoarthritis: The Key to Understanding Pathogenesis?" (2021), Frontiers in Immunology
  • "Interplay between biomaterials and the immune system: Challenges and opportunities in regenerative medicine" (2022), Acta Biomaterialia
  • "In vitro evaluation of the biodegradability of chitosan-genipin hydrogels" (2022), Materials Advances
  • "Preclinical models of arthritis for studying immunotherapy and immune tolerance" (2021), Annals of the Rheumatic Diseases
  • "Challenges in tolerogenic dendritic cell therapy for autoimmune diseases: the route of administration" (2023), Immunotherapy Advances

Collaborations form an important part of their research activity. Frequent co-authors include:

  • John D. Isaacs (12 joint publications)
  • Amy E. Anderson (12 joint publications)
  • Arthur G. Pratt (10 joint publications)
  • Katarina Novakovic (7 joint publications)
  • Ana Marina Ferreira (7 joint publications)

Overall, Catharien M. U. Hilkens's body of work reflects a blend of clinical and biomedical engineering approaches, particularly focused on immunological mechanisms and therapeutic strategies in rheumatologic and autoimmune diseases.

Best Publications

  • T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal.

    Pawel Kaliński;Catharien M.U Hilkens;Eddy A Wierenga;Martien L Kapsenberg

  • IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

    Andreas Schlitzer;Naomi McGovern;Pearline Teo;Teresa Zelante

  • IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.

    P. Kalinski;C.M.U. Hilkens;A. Snijders;F.G.M. Snijdewint

  • α-Type-1 Polarized Dendritic Cells A Novel Immunization Tool with Optimized CTL-inducing Activity

    Robbie B. Mailliard;Anna Wankowicz-Kalinska;Quan Cai;Amy Wesa

  • Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation

    Paweł Kaliński;Joost H. N. Schuitemaker;Catharien M. U. Hilkens;Martien L. Kapsenberg

  • High-level IL-12 production by human dendritic cells requires two signals.

    Alies Snijders;Pawel Kalinski;Catharien M. U. Hilkens;Martien L. Kapsenberg

  • Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study

    Joanna Collerton;Carmen Martin-Ruiz;Karen Davies;Catharien M. Hilkens

  • Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells

    Muzlifah A. Haniffa;Xiao-Nong Wang;Udo Holtick;Michelle Rae

  • Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype

    C.M.U. Hilkens;P. Kalinski;M. de Boer;M.L. Kapsenberg

  • Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells

    Paweł Kaliński;Joost H. N. Schuitemaker;Catharien M. U. Hilkens;Eddy A. Wierenga

  • Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

    A. Snijders;C. M. U. Hilkens;T. C. T. M. Van Der Pouw Kraan;M. Engel

  • Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis

    G M Bell;A E Anderson;J Diboll;R Reece

  • Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation.

    Muzlifah Haniffa;Florent Ginhoux;Xiao-Nong Wang;Venetia Bigley

  • Sustained IL-12 signaling is required for Th1 development.

    Veronica Athie-Morales;Hermelijn H. Smits;Doreen A. Cantrell;Catharien M. U. Hilkens

  • Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis

    Rachel A Harry;Amy E Anderson;John D Isaacs;Catharien M U Hilkens

  • β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function

    Leonie Schittenhelm;Catharien M. Hilkens;Vicky L. Morrison;Vicky L. Morrison

  • Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin‐2

    CM Hilkens;H Vermeulen;van, Neerven, Rj;FG Snijdewint

  • The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy

    M. L. Kapsenberg;C. M. U. Hilkens;E. A. Wierenga;P. Kalinski

  • Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses.

    Jeroen N. Stoop;Rachel A. Harry;Alexei von Delwig;John D. Isaacs

  • Development of dendritic cell-based immunotherapy for autoimmunity

    Catharien M. U. Hilkens;John D. Isaacs;Angus W. Thomson

Frequent Co-Authors

John D. Isaacs
John D. Isaacs Newcastle University
Martien L. Kapsenberg
Martien L. Kapsenberg University of Amsterdam
Pawel Kalinski
Pawel Kalinski Roswell Park Comprehensive Cancer Center
Anne M. Dickinson
Anne M. Dickinson Newcastle University
Muzlifah Haniffa
Muzlifah Haniffa Newcastle University
Eddy A. Wierenga
Eddy A. Wierenga University of Amsterdam
Matthew Collin
Matthew Collin Newcastle University
Willem van Eden
Willem van Eden Utrecht University
Phillip Lord
Phillip Lord Newcastle University
Chris Ward
Chris Ward Newcastle University

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