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Immunology

D-Index
56
Citations
10446
World Ranking
3735
National Ranking
54

Overview

Carlo Heirman is affiliated with the Vrije Universiteit Brussel in Belgium and has contributed to research primarily within the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their research spans several subfields including Oncology, Immunology, Infectious Diseases, Molecular Biology, and Animal Science and Zoology.

The scientist's main topics of work focus on Immunotherapy and Immune Responses, SARS-CoV-2 and COVID-19 Research, Animal Virus Infections Studies, CAR-T cell therapy research, Cutaneous Melanoma Detection and Management, RNA Interference and Gene Delivery, and Single-cell and spatial transcriptomics.

Recent published papers include:

  • A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases, 2020, Cancer Immunology Immunotherapy
  • mRNA-LNP COVID-19 Vaccine Lipids Induce Complement Activation and Production of Proinflammatory Cytokines: Mechanisms, Effects of Complement Inhibitors, and Relevance to Adverse Reactions, 2024, International Journal of Molecular Sciences
  • mRNA-LNP COVID-19 vaccine lipids induce low level complement activation and production of proinflammatory cytokines: Mechanisms, effects of complement inhibitors, and relevance to adverse reactions, 2024, bioRxiv (Cold Spring Harbor Laboratory)
  • Computational staining of CD3/CD20 positive lymphocytes in human tissues with experimental confirmation in a genetically engineered mouse model, 2024, Frontiers in Immunology
  • 1172 Computational Characterization of Immune Dysregulation in Oropharyngeal Squamous Cell Carcinoma, 2025, Laboratory Investigation

Frequent coauthors with whom Carlo Heirman collaborates include:

  • Tamás Bakos
  • Tamás Mészáros
  • Gergely Tibor Kozma
  • Petra Berényi
  • Réka Facskó

Their work has appeared in various scientific venues, notably:

  • Cancer Immunology Immunotherapy
  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Laboratory Investigation

Best Publications

  • CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo.

    Roberto Maldonado-López;Thibaut De Smedt;Patrick Michel;Jacques Godfroid

  • Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation

    M. H. C. Bakkus;C. Heirman;I. Van Riet;B. Van Camp

  • Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma

    Sofie Wilgenhof;Jurgen Corthals;Carlo Heirman;Nicolas van Baren

  • CD83 expression on dendritic cells and T cells: correlation with effective immune responses.

    Cindy Aerts-Toegaert;Carlo Heirman;Sandra Tuyaerts;Jurgen Corthals

  • Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class I and class II molecules.

    Aude Bonehill;Carlo Heirman;Sandra Tuyaerts;Annelies Michiels

  • Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients

    Aude Bonehill;An M.T. Van Nuffel;Jurgen Corthals;Sandra Tuyaerts

  • Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

    Aude Bonehill;Sandra Tuyaerts;An M T Van Nuffel;Carlo Heirman

  • A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients

    S. Wilgenhof;A.M.T. Van Nuffel;D. Benteyn;J. Corthals

  • Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

    Sandra Van Lint;Cleo Goyvaerts;Sarah Maenhout;Lode Goethals

  • Current approaches in dendritic cell generation and future implications for cancer immunotherapy.

    Sandra Tuyaerts;Joeri L. Aerts;Jurgen Corthals;Bart Neyns

  • Role of CD8alpha+ and CD8alpha- dendritic cells in the induction of primary immune responses in vivo.

    R Maldonado-López;T De Smedt;B Pajak;C Heirman

  • Lentivirally transduced dendritic cells as a tool for cancer immunotherapy.

    Karine Breckpot;Melissa Dullaers;Aude Bonehill;Sonja Van Meirvenne

  • A MAGE-A3 Peptide Presented by HLA-DP4 Is Recognized on Tumor Cells by CD4+ Cytolytic T Lymphocytes

    Erwin S Schultz;Bernard Lethé;Cesar L Cambiaso;Jacques Van Snick

  • Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma

    Sofie Wilgenhof;An M.T. Van Nuffel;Jurgen Corthals;Carlo Heirman

  • mRNA-based dendritic cell vaccines

    Daphné Benteyn;Carlo Heirman;Aude Bonehill;Kris Thielemans

  • Generation of large numbers of dendritic cells in a closed system using Cell Factories.

    Sandra Tuyaerts;Sofie M. Noppe;Jurgen Corthals;Karine Breckpot

  • Efficient genetic modification of murine dendritic cells by electroporation with mRNA.

    Sonja Van Meirvenne;Lieven Straetman;Carlo Heirman;Melissa Dullaers

  • The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy.

    Heleen Dewitte;Sandra Van Lint;Carlo Heirman;Kris Thielemans

  • Gain of 20q11.21 in human embryonic stem cells improves cell-survival by increased expression of Bcl-xL

    H.T. Nguyen;M. Geens;A. Mertzanidou;K. Jacobs

  • Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

    Kevin Van der Jeught;Stefaan De Koker;Lukasz Bialkowski;Carlo Heirman

  • Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL).

    Daphné Benteyn;An M. T. Van Nuffel;Sofie Wilgenhof;Jurgen Corthals

  • Induction of effective therapeutic antitumor immunity by direct in vivo administration of lentiviral vectors.

    M Dullaers;S Van Meirvenne;C Heirman;L Straetman

Frequent Co-Authors

Kris Thielemans
Kris Thielemans Vrije Universiteit Brussel
Karine Breckpot
Karine Breckpot Vrije Universiteit Brussel
Pierre van der Bruggen
Pierre van der Bruggen Université Catholique de Louvain
Patrick De Baetselier
Patrick De Baetselier Vrije Universiteit Brussel
Muriel Moser
Muriel Moser Université Libre de Bruxelles
Karin Vanderkerken
Karin Vanderkerken Vrije Universiteit Brussel
Geert Raes
Geert Raes Vrije Universiteit Brussel
Oberdan Leo
Oberdan Leo Université Libre de Bruxelles
Gerold Schuler
Gerold Schuler University of Erlangen-Nuremberg
Viggo Van Tendeloo
Viggo Van Tendeloo University of Antwerp

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