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Immunology

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Overview

Birgit Sawitzki is affiliated with Charité - University Medicine Berlin in Germany. Their research spans multiple fields within Medicine and Immunology and Microbiology, with a focus on Infectious Diseases, Immunology, Neurology, Transplantation, and Oncology.

The scientist's primary research topics include:

  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Long-Term Effects of COVID-19
  • Renal Transplantation Outcomes and Treatments
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Immune cells in cancer

Birgit Sawitzki has contributed to prominent journals and publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • Nature Communications
  • American Journal of Transplantation
  • Frontiers in Immunology

Recent notable papers include:

  • "Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials", 2020, The Lancet
  • "Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment", 2020, Cell
  • "SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis", 2021, Cell
  • "Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children", 2021, Nature Biotechnology
  • "Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination", 2021, Science

Frequent co-authors in their research include:

  • Leif Erik Sander
  • Florian Kurth
  • Victor M. Corman
  • Markus Ralser
  • Philipp Georg

Birgit Sawitzki has also contributed to book publications, such as the work released by Frontiers Media:

  • "The Covid-19 and TB Syndemic: Differences and Similarities", 2023

Their research integrates clinical applications, especially in the context of transplantation immunology and infectious disease control, with investigations into immune cell functions and interactions during viral infections such as COVID-19.

Best Publications

  • Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

    Jonas Schulte-Schrepping;Nico Reusch;Daniela Paclik;Kevin Baßler

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • BamQuery: A new proteogenomic tool to explore the immunopeptidome and validate tumor‐specific antigens

    Maria Virginia Ruiz;Anca Apavaloaei;Qingchuan Zhao;Marie-Pierre Hardy

  • Erythropoietin Is a Paracrine Mediator of Ischemic Tolerance in the Brain: Evidence from an In Vitro Model

    Karsten Ruscher;Dorette Freyer;Maria Karsch;Nikolai Isaev

  • Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

    Pervinder Sagoo;Esperanza Perucha;Birgit Sawitzki;Stefan Tomiuk

  • SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

    Daniel Wendisch;Oliver Dietrich;Tommaso Mari;Saskia von Stillfried

  • Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.

    Birgit Sawitzki;Paul N Harden;Petra Reinke;Aurélie Moreau

  • IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo.

    Birgit Sawitzki;Birgit Sawitzki;Cherry I. Kingsley;Vanessa Oliveira;Mahzuz Karim

  • Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.

    Joana P. Bernardes;Neha Mishra;Florian Tran;Thomas Bahmer

  • Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children.

    Jennifer Loske;Jobst Röhmel;Soeren Lukassen;Sebastian Stricker

  • Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

    Caroline von Spee-Mayer;Elise Siegert;Dimas Abdirama;Angelika Rose

  • Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans.

    Petra Bacher;Frederik Heinrich;Ulrik Stervbo;Mikalai Nienen

  • Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.

    Lucie Loyal;Lucie Loyal;Julian Braun;Julian Braun;Larissa Henze;Larissa Henze;Beate Kruse;Beate Kruse

  • Alloantigen-Induced CD25+CD4+ Regulatory T Cells Can Develop In Vivo from CD25−CD4+ Precursors in a Thymus-Independent Process

    Mahzuz Karim;Cherry I. Kingsley;Andrew R. Bushell;Birgit S. Sawitzki

  • Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

    James A. Hutchinson;James A. Hutchinson;Paloma Riquelme;Paloma Riquelme;Birgit Sawitzki;Birgit Sawitzki;Stefan Tomiuk;Stefan Tomiuk

  • Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

    Mario Witkowski;Mario Witkowski;Caroline Tizian;Marta Ferreira-Gomes;Daniela Niemeyer;Daniela Niemeyer

  • Interferon γ: a crucial role in the function of induced regulatory T cells in vivo

    Kathryn J. Wood;Birgit Sawitzki;Birgit Sawitzki

  • Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

    Benjamin Krämer;Rainer Knoll;Lorenzo Bonaguro;Michael ToVinh

  • Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1.

    Stefan G. Tullius;Melina Nieminen-Kelhä;Roland Buelow;Anja Reutzel-Selke

  • Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study

    Mathias Streitz;Tewfik Miloud;Michael Kapinsky;Michael R Reed

  • Complement activation induces excessive T cell cytotoxicity in severe COVID-19

    Unknown

  • Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

    Pawel Durek;Karl Nordström;Gilles Gasparoni;Abdulrahman Salhab

  • A time-resolved proteomic and prognostic map of COVID-19.

    Vadim Demichev;Vadim Demichev;Vadim Demichev;Pinkus Tober-Lau;Oliver Lemke;Tatiana Nazarenko

Frequent Co-Authors

Hans-Dieter Volk
Hans-Dieter Volk Charité - University Medicine Berlin
Petra Reinke
Petra Reinke Berlin-Brandenburger Centrum für Regenerative Therapien
Kathryn J. Wood
Kathryn J. Wood University of Oxford
Edward K. Geissler
Edward K. Geissler University of Regensburg
Peter Neuhaus
Peter Neuhaus Charité - University Medicine Berlin
Joachim L. Schultze
Joachim L. Schultze University of Bonn
Andreas Radbruch
Andreas Radbruch German Rheumatism Research Centre
Giovanna Lombardi
Giovanna Lombardi King's College London
Robert Sabat
Robert Sabat Charité - University Medicine Berlin

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