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D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
18455
World Ranking
12302
National Ranking
5264

Overview

Taiping Chen is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a primary focus on molecular biology and its intersections with related subfields such as organic chemistry, immunology, mechanical engineering, and oncology.

The main topics covered in their work include:

  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • RNA modifications and cancer
  • Genomics and Chromatin Dynamics
  • Immune Cell Function and Interaction
  • Acute Myeloid Leukemia Research
  • Genetics and Neurodevelopmental Disorders

Taiping Chen has authored various scientific publications, with notable papers including:

  • The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation (2020, Genes & Development)
  • Dynamic load test on progressive collapse resistance of fully assembled precast concrete frame structures (2020, Engineering Structures)
  • PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade (2022, Cell Reports)
  • The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation (2020, Protein & Cell)
  • Evolution of char structure during non-isothermal low temperature pyrolysis of ZhunDong coal by microwave heating: A comparative study with conventional heating (2020, Journal of the Energy Institute)

The scientist collaborates frequently with several coauthors, among them:

  • Swanand Hardikar
  • Xiaodong Cheng
  • Zhengzhou Ying
  • Bigang Liu
  • Jiameng Dan

Their research is regularly published in prominent venues such as:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Cell Reports
  • NAR Cancer

With 63 publications categorized under Biochemistry, Genetics and Molecular Biology, and 58 specifically in Molecular Biology, their body of work shows a consistent focus on the molecular mechanisms underlying genetic regulation and cancer biology. The presence of works in mechanical engineering and related subfields reflects interdisciplinary approaches in some of the research activities.

Best Publications

  • Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

    Bernhard Lehnertz;Yoshihide Ueda;Alwin A.H.A. Derijck;Ulrich Braunschweig

  • Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.

    Taiping Chen;Yoshihide Ueda;Jonathan E. Dodge;Zhenjuan Wang

  • The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

    Jing Wang;Sarah Hevi;Julia K Kurash;Hong Lei

  • DNA methyltransferases control telomere length and telomere recombination in mammalian cells.

    Susana Gonzalo;Isabel Jaco;Mario F. Fraga;Taiping Chen

  • Chromatin modifiers and remodellers: regulators of cellular differentiation

    Taiping Chen;Sharon Y. R. Dent

  • Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

    Yufei Xu;Feizhen Wu;Li Tan;Lingchun Kong

  • KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

    David N. Ciccone;Hui Su;Sarah Hevi

  • A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

    Roberta Benetti;Susana Gonzalo;Susana Gonzalo;Isabel Jaco;Purificación Muñoz

  • A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.

    Taiping Chen;Yoshihide Ueda;Shaoping Xie;En Li

  • Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

    Taiping Chen;Sarah Hevi;Naomi Tsujimoto

  • The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.

    Brendan Jones;Hui Su;Audesh Bhat;Hong Lei

  • The PWWP Domain of Dnmt3a and Dnmt3b Is Required for Directing DNA Methylation to the Major Satellite Repeats at Pericentric Heterochromatin

    Taiping Chen;Naomi Tsujimoto;Naomi Tsujimoto;En Li;En Li

  • Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization.

    Jonathan E. Dodge;Masaki Okano;Fred Dick;Naomi Tsujimoto

  • Ring1b-mediated H2A Ubiquitination Associates with Inactive X Chromosomes and Is Involved in Initiation of X Inactivation

    Jia Fang;Taiping Chen;Brian Chadwick;En Li

  • Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells

    Matthias Stadtfeld;Effie Apostolou;Francesco Ferrari;Jiho Choi

  • Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

    Jing Yu Li;Min Tie Pu;Ryutaro Hirasawa;Ryutaro Hirasawa;Bin Zhong Li

  • Genetic alterations of DNA methylation machinery in human diseases

    Tewfik Hamidi;Anup Kumar Singh;Taiping Chen

  • Self-Association of the Single-KH-Domain Family Members Sam68, GRP33, GLD-1, and Qk1: Role of the KH Domain

    Taiping Chen;Bassam B. Damaj;Constance Herrera;Paul Lasko

  • Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells

    Hyun Soo Cho;Takehiro Suzuki;Naoshi Dohmae;Shinya Hayami

  • A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases (Nature Structural and Molecular Biology (2008) 15, (268-279))

    Roberta Benetti;Susana Gonzalo;Isabel Jaco;Purificación Mũoz

Frequent Co-Authors

S.B. Richard
S.B. Richard McGill University
En Li
En Li Harvard University
Guoliang Xu
Guoliang Xu Fudan University
Hiroyuki Sasaki
Hiroyuki Sasaki Kyushu University
Yi Zhang
Yi Zhang Harvard University
Jianjun Shen
Jianjun Shen The University of Texas MD Anderson Cancer Center
Xiaodong Cheng
Xiaodong Cheng The University of Texas MD Anderson Cancer Center
Paul Lasko
Paul Lasko McGill University
Maria A. Blasco
Maria A. Blasco Spanish National Cancer Research Centre
Stuart H. Orkin
Stuart H. Orkin Harvard University

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