World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
67
Citations
12466
World Ranking
2706
National Ranking
24

Overview

Zhe-Xiong Lian is affiliated with the University of Science and Technology of China. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with a strong emphasis on subfields such as Immunology, Epidemiology, Hepatology, Oncology, and Surgery.

The main topics explored in their work include:

  • Liver Diseases and Immunity
  • Immune Cell Function and Interaction
  • Liver Disease Diagnosis and Treatment
  • Immune cells in cancer
  • Pediatric Hepatobiliary Diseases and Treatments
  • Cancer Immunotherapy and Biomarkers
  • T-cell and B-cell Immunology

Zhe-Xiong Lian has contributed to numerous scientific papers, some of which have notable citation counts. Selected recent papers include:

  • "Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer," 2023, Science Advances
  • "Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis," 2020, Proceedings of the National Academy of Sciences
  • "Immunobiology of T Cells in Sjögren's Syndrome," 2020, Clinical Reviews in Allergy & Immunology
  • "The Clinical Significance of Hepatic CD69+CD103+CD8+ Resident-Memory T Cells in Autoimmune Hepatitis," 2021, Hepatology
  • "Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+ T cells in primary Sjögren's syndrome," 2023, JCI Insight

Their frequent coauthors include Liang Li, Zhibin Zhao, M. Eric Gershwin, Cai-Yue Gao, and Jie Long, indicating collaboration with researchers active in related fields.

Publications by Zhe-Xiong Lian frequently appear in several scientific venues such as:

  • Clinical Reviews in Allergy & Immunology
  • Frontiers in Immunology
  • Proceedings of the National Academy of Sciences
  • JCI Insight
  • Journal of Hepatology

Best Publications

  • Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

    Jian Wang;Fengqi Li;Haiming Wei;Zhe-Xiong Lian

  • Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells.

    Hiroto Kita;Zhe-Xiong Lian;Judy Van de Water;Xiao-Song He

  • Liver‐targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis

    Ruth Y. Lan;Chunmei Cheng;Zhe Xiong Lian;Koichi Tsuneyama

  • Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

    Hiroto Kita;Shuji Matsumura;Xiaosong He;Aftab A. Ansari

  • Anti-Mitochondrial Antibodies and Primary Biliary Cirrhosis in TGF-β Receptor II Dominant-Negative Mice

    Sabine Oertelt;Zhe Xiong Lian;Chun Mei Cheng;Ya Hui Chuang

  • Regulatory T cells: development, function and role in autoimmunity.

    Ruth Y. Lan;Aftab A. Ansari;Zhe Xiong Lian;M. Eric Gershwin

  • Hepatic IL-17 responses in human and murine primary biliary cirrhosis.

    Ruth Y Z Lan;Thucydides L. Salunga;Koichi Tsuneyama;Zhe Xiong Lian

  • IL‐2 receptor α−/− mice and the development of primary biliary cirrhosis

    Kanji Wakabayashi;Zhe-Xiong Lian;Yuki Moritoki;Ruth Y Lan

  • Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride

    Ogyi Park;Won Il Jeong;Lei Wang;Hua Wang

  • Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis

    Tin K Mao;Zhe-Xiong Lian;Carlo Selmi;Carlo Selmi;Yasunori Ichiki

  • TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING.

    Yanming Wang;Qiaoshi Lian;Bo Yang;Shanshan Yan

  • The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner.

    Fenglei Li;Xiaolei Hao;Yongyan Chen;Li Bai

  • Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease

    Kanji Wakabayashi;Kanji Wakabayashi;Zhe-Xiong Lian;Patrick S C Leung;Yuki Moritoki

  • IL-2 receptor alpha deficiency and features of primary biliary cirrhosis.

    Christopher A Aoki;Chaim M Roifman;Zhe-Xiong Lian;Christopher L Bowlus

  • Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid.

    Masanobu Tsuda;Masanobu Tsuda;Yuki Moritoki;Yuki Moritoki;Zhe Xiong Lian;Zhe Xiong Lian;Weici Zhang

  • Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis.

    Kentaro Kikuchi;Zhe-Xiong Lian;Guo-Xiang Yang;Aftab A Ansari

  • Traditional Chinese medicine and immune regulation.

    Hong-Di Ma;Yan-Ru Deng;Zhigang Tian;Zhe-Xiong Lian

  • Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations.

    Zhe Xiong Lian;Tomoyuki Okada;Xiaosong He;Hiroto Kita

  • Deletion of interleukin‐12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor β receptor type II mice

    Katsunori Yoshida;Guo-Xiang Yang;Weici Zhang;Masanobu Tsuda

  • Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis.

    Ya Hui Chuang;Zhe Xiong Lian;Koichi Tsuneyama;Bor Luen Chiang

  • Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review.

    Wen Tao Ma;Christopher Chang;M. Eric Gershwin;Zhe Xiong Lian;Zhe Xiong Lian

Frequent Co-Authors

M. Eric Gershwin
M. Eric Gershwin University of California, Davis
Aftab A. Ansari
Aftab A. Ansari University of California, Davis
Susumu Ikehara
Susumu Ikehara Kansai Medical University
Ross L. Coppel
Ross L. Coppel Monash University
Koichi Tsuneyama
Koichi Tsuneyama University of Tokushima
Xiao-Song He
Xiao-Song He University of California, Davis
Ian R. Mackay
Ian R. Mackay Monash University
Richard A. Flavell
Richard A. Flavell Yale University
Yong-Jun Liu
Yong-Jun Liu University of Washington
Carlo Selmi
Carlo Selmi Humanitas University

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