World's Best Scientists 2026 revealed!

Overview

Zhe-Xiong Lian is affiliated with the University of Science and Technology of China and has an extensive research portfolio in medicine, particularly focusing on immunology and microbiology. Their body of work spans various subfields, including immunology, epidemiology, hepatology, oncology, and surgery. The primary themes of their research integrate liver diseases and immunity, immune cell function and interaction, and cancer immunotherapy and biomarkers, with additional emphasis on pediatric hepatobiliary diseases and treatment as well as T-cell and B-cell immunology.

The scientist has contributed to multiple frequent publication venues, including:

  • Clinical Reviews in Allergy & Immunology
  • Frontiers in Immunology
  • Proceedings of the National Academy of Sciences
  • JCI Insight
  • Journal of Hepatology

Zhe-Xiong Lian's recent scholarly papers demonstrate a focus on immune cell biology and its clinical applications. Notable publications include:

  • Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer, 2023, Science Advances
  • Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis, 2020, Proceedings of the National Academy of Sciences
  • Immunobiology of T Cells in Sjögren's Syndrome, 2020, Clinical Reviews in Allergy & Immunology
  • The Clinical Significance of Hepatic CD69+CD103+CD8+ Resident-Memory T Cells in Autoimmune Hepatitis, 2021, Hepatology
  • Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+ T cells in primary Sjögren's syndrome, 2023, JCI Insight

The scientist has established collaborations with a number of frequent co-authors, indicating interdisciplinary and collaborative research efforts. These co-authors include Liang Li, Zhibin Zhao, M. Eric Gershwin, Cai-Yue Gao, and Jie Long.

The main areas of study include:

  • Medicine
  • Immunology and Microbiology

Within these fields, the subfields they contribute to most are:

  • Immunology
  • Epidemiology
  • Hepatology
  • Oncology
  • Surgery

The central topics covered in their research focus on:

  • Liver Diseases and Immunity
  • Immune Cell Function and Interaction
  • Liver Disease Diagnosis and Treatment
  • Immune cells in cancer
  • Pediatric Hepatobiliary Diseases and Treatments
  • Cancer Immunotherapy and Biomarkers
  • T-cell and B-cell Immunology

Best Publications

  • Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

    Jian Wang;Fengqi Li;Haiming Wei;Zhe-Xiong Lian

  • Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells.

    Hiroto Kita;Zhe-Xiong Lian;Judy Van de Water;Xiao-Song He

  • Liver‐targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis

    Ruth Y. Lan;Chunmei Cheng;Zhe Xiong Lian;Koichi Tsuneyama

  • Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

    Hiroto Kita;Shuji Matsumura;Xiaosong He;Aftab A. Ansari

  • Anti-Mitochondrial Antibodies and Primary Biliary Cirrhosis in TGF-β Receptor II Dominant-Negative Mice

    Sabine Oertelt;Zhe Xiong Lian;Chun Mei Cheng;Ya Hui Chuang

  • Hepatic IL-17 responses in human and murine primary biliary cirrhosis.

    Ruth Y Z Lan;Thucydides L. Salunga;Koichi Tsuneyama;Zhe Xiong Lian

  • IL‐2 receptor α−/− mice and the development of primary biliary cirrhosis

    Kanji Wakabayashi;Zhe-Xiong Lian;Yuki Moritoki;Ruth Y Lan

  • Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride

    Ogyi Park;Won Il Jeong;Lei Wang;Hua Wang

  • Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis

    Tin K Mao;Zhe-Xiong Lian;Carlo Selmi;Carlo Selmi;Yasunori Ichiki

  • TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING.

    Yanming Wang;Qiaoshi Lian;Bo Yang;Shanshan Yan

  • The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner.

    Fenglei Li;Xiaolei Hao;Yongyan Chen;Li Bai

  • Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

    Unknown

  • Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease

    Kanji Wakabayashi;Kanji Wakabayashi;Zhe-Xiong Lian;Patrick S C Leung;Yuki Moritoki

  • IL-2 receptor alpha deficiency and features of primary biliary cirrhosis.

    Christopher A Aoki;Chaim M Roifman;Zhe-Xiong Lian;Christopher L Bowlus

  • Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis.

    Kentaro Kikuchi;Zhe-Xiong Lian;Guo-Xiang Yang;Aftab A Ansari

  • Traditional Chinese medicine and immune regulation.

    Hong-Di Ma;Yan-Ru Deng;Zhigang Tian;Zhe-Xiong Lian

  • Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations.

    Zhe Xiong Lian;Tomoyuki Okada;Xiaosong He;Hiroto Kita

  • Deletion of interleukin‐12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor β receptor type II mice

    Katsunori Yoshida;Guo-Xiang Yang;Weici Zhang;Masanobu Tsuda

  • Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis.

    Ya Hui Chuang;Zhe Xiong Lian;Koichi Tsuneyama;Bor Luen Chiang

  • Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review.

    Wen Tao Ma;Christopher Chang;M. Eric Gershwin;Zhe Xiong Lian;Zhe Xiong Lian

  • A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

    Fang Qiu;Ruqi Tang;Xianbo Zuo;Xingjuan Shi

  • Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice

    Kele Cui;Guoxiu Yan;Congfei Xu;Yongyan Chen

Frequent Co-Authors

M. Eric Gershwin
M. Eric Gershwin University of California, Davis
Zhigang Tian
Zhigang Tian University of Science and Technology of China
Wei Yang
Wei Yang South China University of Technology
Aftab A. Ansari
Aftab A. Ansari University of California, Davis
Patrick S.C. Leung
Patrick S.C. Leung University of California, Davis
Ross L. Coppel
Ross L. Coppel Monash University
Haiming Wei
Haiming Wei University of Science and Technology of China
Carlo Selmi
Carlo Selmi Humanitas University
Rui Sun
Rui Sun University of Science and Technology of China
Joachim L. Schultze
Joachim L. Schultze University of Bonn

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