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D-Index & Metrics

Molecular Biology

D-Index
58
Citations
11647
World Ranking
2092
National Ranking
59

Overview

Wai-Yee Chan is affiliated with the Chinese University of Hong Kong in China. Their research spans several areas within biochemistry, genetics, molecular biology, and medicine, with numerous contributions to molecular biology and genetics fields.

The scientist's work covers multiple subfields including:

  • Molecular Biology
  • Genetics
  • Public Health, Environmental and Occupational Health
  • Immunology
  • Cancer Research

Main topics addressed in Wai-Yee Chan's research include:

  • Reproductive Biology and Fertility
  • Chronic Lymphocytic Leukemia Research
  • Epigenetics and DNA Methylation
  • RNA Research and Splicing
  • Lymphoma Diagnosis and Treatment
  • Pluripotent Stem Cells Research
  • Reproductive System and Pregnancy

Their research has been published frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood Advances
  • Journal of Clinical Oncology
  • Frontiers in Cell and Developmental Biology
  • Blood

Wai-Yee Chan has collaborated extensively with several coauthors, including:

  • Gang Lü
  • Hongbin Liu
  • Zi-Jiang Chen
  • Constantine S. Tam
  • Roger G. Owen

Some recent papers authored by Wai-Yee Chan include:

  • A randomized phase 3 trial of zanubrutinib vs ibrutinib in symptomatic Waldenström macroglobulinemia: the ASPEN study (2020, Blood)
  • Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1 (2020, Nucleic Acids Research)
  • Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation (2022, Nature Communications)
  • Pooled safety analysis of zanubrutinib monotherapy in patients with B-cell malignancies (2021, Blood Advances)
  • Zanubrutinib Versus Ibrutinib in Symptomatic Waldenström Macroglobulinemia: Final Analysis From the Randomized Phase III ASPEN Study (2023, Journal of Clinical Oncology)

Best Publications

  • Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications.

    Randy Chi Fai Cheung;Tzi Bun Ng;Jack Ho Wong;Wai Yee Chan

  • A research agenda for aging in China in the 21st century

    Evandro Fei Fang;Morten Scheibye-Knudsen;Heiko J. Jahn;Juan Li

  • Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth.

    Wai Yee Chan;Qing Rong Liu;Jimo Borjigin;Harris Busch

  • Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty.

    Louisa Laue;Wai-Yee Chan;Aaron J. W. Hsueh;M. Kudo

  • MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases

    Dan-Dan Cao;Lu Li;Wai-Yee Chan

  • DNA methylation of cancer genome

    Hoi-Hung Cheung;Tin-Lap Lee;Owen M. Rennert;Wai-Yee Chan;Wai-Yee Chan

  • Characterization of a complementary deoxyribonucleic acid coding for the gamma chain of human fibrinogen.

    Dominic W. Chung;Wai Yee Chan;Earl W. Davie

  • A nonsense mutation of the human luteinizing hormone receptor gene in Leydig cell hypoplasia

    Louisa Laue;Shao-Ming Wu;Masataka Kudo;Aaron J.W. Hsueh

  • Compound heterozygous mutations of the luteinizing hormone receptor gene in Leydig cell hypoplasia.

    L. L. Laue;S.-M. Wu;M. Kudo;C. J. Bourdony

  • Methylation of an intronic region regulates miR-199a in testicular tumor malignancy

    Cheung Hh;Davis Aj;Lee Tl;Pang Al

  • Retinoic acid receptor-β: an endogenous inhibitor of the perinatal formation of pulmonary alveoli

    Gloria De Carlo Massaro;Donald Massaro;Wai-Yee Chan;Linda B. Clerch

  • Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer.

    H H Cheung;T L Lee;A J Davis;D H Taft

  • TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells

    Shane W Oram;Xing Xing Liu;Tin-Lap Lee;Wai-Yee Chan

  • Downregulation of metastasis suppressor genes in malignant pheochromocytoma.

    Shoichiro Ohta;Edwin W. Lai;Alan L.Y. Pang;Frederieke M. Brouwers

  • Snake venom toxins: toxicity and medicinal applications

    Yau Sang Chan;Randy Chi Fai Cheung;Lixin Xia;Jack Ho Wong

  • Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers

    Lili Li;Chen Li;Haitao Mao;Zhenfang Du

  • Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway.

    Xiao Chen;Shen Gu;Bi-Feng Chen;Wei-Liang Shen

  • Long Noncoding RNAs in Spermatogenesis: Insights From Recent High-Throughput Transcriptome Studies

    Alfred Chun-Shui Luk;Wai-Yee Chan;Owen M Rennert;Tin-Lap Lee

  • The Molecular Signature of Spermatogonial Stem/Progenitor Cells in the 6-Day-Old Mouse Testis

    Maria Kokkinaki;Tin Lap Lee;Zuping He;Jiji Jiang

  • The role of the placenta in fetal nutrition and growth.

    Adolfo D. Garnica;Wai-Yee Chan

Frequent Co-Authors

Martin Dym
Martin Dym Georgetown University Medical Center
Tzi Bun Ng
Tzi Bun Ng Chinese University of Hong Kong
Qian Tao
Qian Tao Chinese University of Hong Kong
Kwok-Pui Fung
Kwok-Pui Fung Chinese University of Hong Kong
Ping-Chung Leung
Ping-Chung Leung Chinese University of Hong Kong
Peter C.K. Leung
Peter C.K. Leung University of British Columbia
Anthony T.C. Chan
Anthony T.C. Chan Chinese University of Hong Kong
Duanqing Pei
Duanqing Pei Westlake University
Tin-Chiu Li
Tin-Chiu Li Chinese University of Hong Kong
Constantine A. Stratakis
Constantine A. Stratakis Foundation for Research and Technology Hellas

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