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Deborah L. Segaloff

Deborah L. Segaloff

D-Index & Metrics

Molecular Biology

D-Index
52
Citations
9532
World Ranking
2441
National Ranking
1202

Overview

Deborah L. Segaloff is affiliated with the University of Iowa in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a range of work that also touches on Molecular Biology, Radiology, Nuclear Medicine and Imaging, Cell Biology, Public Health, Environmental and Occupational Health, and Reproductive Medicine.

Their publications demonstrate a focus on receptor mechanisms and signaling, particularly related to glycoprotein hormone receptors. This is reflected in their recent papers, which include:

  • Glycoprotein hormone receptors in GtoPdb v.2023.1, published in 2023 in IUPHAR/BPS Guide to Pharmacology CITE
  • Glycoprotein hormone receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database, published in 2020 in IUPHAR/BPS Guide to Pharmacology CITE

Their research topics cover several areas within biomedical science, including:

  • Receptor Mechanisms and Signaling
  • Monoclonal and Polyclonal Antibodies Research
  • Biotin and Related Studies
  • Pregnancy-related medical research
  • Hypothalamic control of reproductive hormones
  • Growth Hormone and Insulin-like Growth Factors

They frequently collaborate with several other researchers on their topics of interest. Notable co-authors include Sabine Costagliola, James A. Dias, Marvin C. Gershengorn, Adam J Pawson, and Axel P. N. Themmen, with collaboration counts indicating repeated joint work particularly with these scientists.

The scientist has contributed primarily to the IUPHAR/BPS Guide to Pharmacology CITE publication venue, where their work on glycoprotein hormone receptors has been documented.

Best Publications

  • Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.

    K. C. McFarland;Rolf Sprengel;Heidi S. Phillips;Martin Köhler

  • The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective

    Mario Ascoli;Francesca Fanelli;Deborah L. Segaloff

  • The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA

    Rolf Sprengel;Thomas Braun;Károly Nikolics;Deborah L. Segaloff

  • The Lutropin/Choriogonadotropin Receptor… 4 Years Later*

    Deborah L. Segaloff;Mario Ascoli

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

    Stephen P.H. Alexander;Arthur Christopoulos;Anthony P. Davenport;Eamonn Kelly

  • Extracellular Domain of Lutropin/ Choriogonadotropin Receptor - . Expressed in Transfected Cells Binds Choriogonadotropin with High Affinity*

    Unknown

  • Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization

    Deborah L. Segaloff;Haiyun Wang;Haiyun Wang;JoAnne S. Richards

  • Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function.

    Unknown

  • Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity.

    Unknown

  • Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.

    A. Lindsay Frazier;A. Lindsay Frazier;Linda S. Robbins;Philip J. Stork;Rolf Sprengel

  • A Homozygous Microdeletion in Helix 7 of the Luteinizing Hormone Receptor Associated with Familial Testicular and Ovarian Resistance Is Due to Both Decreased Cell Surface Expression and Impaired Effector Activation by the Cell Surface Receptor

    Ana C. Latronico;Yaohui Chai;Ivo J.P. Arnhold;Xuebo Liu

  • Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor-mediated hormone internalization.

    Unknown

  • Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA.

    Haiyun Wang;D. L. Segaloff;M. Ascoli

  • Expression and Localization of Luteinizing Hormone Receptor in the Female Mouse Reproductive Tract

    Unknown

  • On the Structure of the Luteinizing Hormone/Chorionic Gonadotropin Receptor*

    Mario Ascoli;Deborah L. Segaloff

  • Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist

    Claire L. Newton;Adele M. Whay;Craig A. McArdle;Meilin Zhang

  • The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction.

    Unknown

  • Intracellularly located misfolded glycoprotein hormone receptors associate with different chaperone proteins than their cognate wild-type receptors.

    Unknown

  • Constitutive and Agonist-dependent Self-association of the Cell Surface Human Lutropin Receptor

    Unknown

  • Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.

    Unknown

Frequent Co-Authors

Mario Ascoli
Mario Ascoli University of Iowa
Berenice B. Mendonca
Berenice B. Mendonca Universidade de São Paulo
Ilpo Huhtaniemi
Ilpo Huhtaniemi Imperial College London
Terence E. Hébert
Terence E. Hébert McGill University
Gordon Stamp
Gordon Stamp The Francis Crick Institute
George P. Chrousos
George P. Chrousos National and Kapodistrian University of Athens
Jean-Martin Beaulieu
Jean-Martin Beaulieu University of Toronto
Charles Kennedy
Charles Kennedy University of Strathclyde
Trent M. Woodruff
Trent M. Woodruff University of Queensland
Ji Ming Wang
Ji Ming Wang National Institutes of Health

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