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Biology and Biochemistry

D-Index
66
Citations
12240
World Ranking
8871
National Ranking
3945

Overview

P. Michael Conn was affiliated with Texas Tech University Health Sciences Center in the United States. Their research contributed to the fields of Biochemistry, Genetics and Molecular Biology, with a focus on Cell Biology as a subfield.

The scientist's work addressed topics primarily related to Endoplasmic Reticulum Stress and Disease.

One of their recorded papers is titled Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR, published in 2020 by UNC Libraries.

  • Scott A. Houck
  • Hong Yu Ren
  • Victoria J. Madden
  • Jaclyn N. Bonner
  • Michael P. Conlin

  • UNC Libraries

Best Publications

  • Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines.

    Ursula B. Kaiser;P. Michael Conn;William W. Chin

  • Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.

    Alfredo Ulloa-Aguirre;Jo Ann Janovick;P. Michael Conn

  • Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target

    Jo Ann Janovick;Guadalupe Maya-Nunez;P. Michael Conn

  • G Protein-Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo

    P. Michael Conn;Alfredo Ulloa-Aguirre;Joel Ito;Jo Ann Janovick

  • Pharmacological Profile of a New, Potent, and Long-Acting Gonadotropin-Releasing Hormone Antagonist: Degarelix

    Pierre Broqua;Pierre J.-M. Riviere;P. Michael Conn;Jean E. Rivier

  • Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor

    Jo Ann Janovick;Mark Goulet;Eugene Bush;Jonathan Greer

  • Gonadotropin-Releasing Hormone Stimulates Mass Changes in Phosphoinositides and Diacylglycerol Accumulation in Purified Gonadotrope Cell Cultures*

    William V. Andrews;P. Michael Conn

  • Receptor-Misrouting: An Unexpectedly Prevalent and Rescuable Etiology in Gonadotropin-Releasing Hormone Receptor-Mediated Hypogonadotropic Hypogonadism

    Alfredo Leaños-Miranda;Jo Ann Janovick;P. Michael Conn

  • Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR.

    Scott A. Houck;Hong Yu Ren;Victoria J. Madden;Jaclyn N. Bonner

  • Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C

    P.Michael Conn;P.Michael Conn;Barry R. Ganong;James Ebeling;Daphne Staley

  • Gonadotropin-releasing hormone receptor microaggregation. Rate monitored by fluorescence resonance energy transfer.

    Anda Cornea;Jo Ann Janovick;Guadalupe Maya-Núñez;P. Michael Conn

  • Addition of Catfish Gonadotropin-Releasing Hormone (GnRH) Receptor Intracellular Carboxyl-Terminal Tail to Rat GnRH Receptor Alters Receptor Expression and Regulation

    Xinwei Lin;Jo Ann Janovick;Marion Blömenrohr

  • Distribution of gonadrotropin releasing hormone agonist binding sites in the rat central nervous system

    Lothar Jennes;Burhan Dalati;P. Michael Conn

  • Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics

    Ya-Xiong Tao;P. Michael Conn

  • Regulation of Gq/11α by the Gonadotropin-Releasing Hormone Receptor

    Dinesh Stanislaus;Jo Ann Janovick;P. Michael Conn

  • Evidence of Differential Control of FSH and LH Secretion by Gonadotropin-Releasing Hormone (GnRH) from the Use of a GnRH Antagonist

    Janet E. Hall;Todd D. Brodie;Thomas M. Badger;Jean Rivier

  • Cis- and trans-activation of hormone receptors: the LH receptor.

    Inhae Ji;ChangWoo Lee;YongSang Song;P. Michael Conn

  • Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs

    P. Michael Conn;P. Michael Conn;P. Michael Conn;Alfredo Ulloa-Aguirre;Alfredo Ulloa-Aguirre

  • Dominant-negative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans.

    Alfredo Leaños-Miranda;Alfredo Leaños-Miranda;Alfredo Leaños-Miranda;Alfredo Ulloa-Aguirre;Alfredo Ulloa-Aguirre;Alfredo Ulloa-Aguirre;Tae H. Ji;Jo Ann Janovick;Jo Ann Janovick

  • Human Loss-of-Function Gonadotropin-Releasing Hormone Receptor Mutants Retain Wild-Type Receptors in the Endoplasmic Reticulum: Molecular Basis of the Dominant-Negative Effect

    Anda Cornea;Jo Ann Janovick;P. Michael Conn

Frequent Co-Authors

Alfredo Ulloa-Aguirre
Alfredo Ulloa-Aguirre National Autonomous University of Mexico
Jean Rivier
Jean Rivier Salk Institute for Biological Studies
Ursula B. Kaiser
Ursula B. Kaiser Brigham and Women's Hospital
William F. Crowley
William F. Crowley Harvard University
Richard R. Behringer
Richard R. Behringer The University of Texas MD Anderson Cancer Center
Wylie Vale
Wylie Vale Salk Institute for Biological Studies
Thomas M. Badger
Thomas M. Badger University of Arkansas for Medical Sciences
Richard E. Peter
Richard E. Peter University of Alberta
Henry I. Mosberg
Henry I. Mosberg University of Michigan–Ann Arbor
Janet E. Hall
Janet E. Hall National Institutes of Health

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