Stefani Spranger

Overview

Best Publications

• Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

  Stefani Spranger;Riyue Bao;Thomas F. Gajewski

  2837
  Citations

• Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.

  Stefani Spranger;Robbert M. Spaapen;Yuanyuan Zha;Jason Williams

  1878
  Citations

• STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

  Seng Ryong Woo;Mercedes Beatriz Fuertes;Leticia Corrales;Stefani Spranger

  1829
  Citations

• Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

  Weiyi Peng;Jie Qing Chen;Chengwen Liu;Shruti Malu

  1592
  Citations

• Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.

  Stefani Spranger;Daisy Dai;Brendan Horton;Thomas F. Gajewski

  1400
  Citations

• Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8 + T cells directly within the tumor microenvironment

  Stefani Spranger;Holly K Koblish;Brendan Horton;Peggy A Scherle

  732
  Citations

• Impact of oncogenic pathways on evasion of antitumour immune responses

  Stefani Spranger;Thomas F. Gajewski

  662
  Citations

• WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers

  Jason J. Luke;Riyue Bao;Randy F. Sweis;Stefani Spranger

  660
  Citations

• Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment

  Thomas F Gajewski;Seng-Ryong Woo;Yuanyuan Zha;Robbert Spaapen

  477
  Citations

• Innate immune signaling and regulation in cancer immunotherapy

  Leticia Corrales;Vyara Matson;Blake Flood;Stefani Spranger

  425
  Citations

• Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma.

  Stefani Spranger;Jason J Luke;Riyue Bao;Yuanyuan Zha

  416
  Citations

• Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer.

  Randy F. Sweis;Stefani Spranger;Riyue Bao;Gladell P. Paner

  354
  Citations

• Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity.

  Ellen Duong;Tim B. Fessenden;Emi Lutz;Teresa Dinter

  328
  Citations

• Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy

  Lijie Zhai;Stefani Spranger;David C. Binder;Galina Gritsina

  322
  Citations

• Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment

  Stefani Spranger

  309
  Citations

• Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment

  Thomas F. Gajewski;Leticia Corrales;Jason Williams;Brendan Horton

  286
  Citations

• Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

  Daniel Nagel;Stefani Spranger;Michelle Vincendeau;Michael Grau

  256
  Citations

• Future perspectives in melanoma research

  Paolo A. Ascierto;Sanjiv Agarwala;Gerardo Botti;Alessandra Cesano

  246
  Citations

• WNT Signaling in Cancer Immunosurveillance.

  Lorenzo Galluzzi;Lorenzo Galluzzi;Stefani Spranger;Elaine Fuchs;Alejandro López-Soto

  225
  Citations

• Lymphatic vessels regulate immune microenvironments in human and murine melanoma

  Amanda W. Lund;Marek Wagner;Manuel Fankhauser;Eli S. Steinskog

  202
  Citations