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Biology and Biochemistry

D-Index
66
Citations
21562
World Ranking
8491
National Ranking
76

Overview

Iris Barshack is affiliated with Sheba Medical Center in Israel and has a significant publication record in the fields of medicine, biochemistry, genetics, and molecular biology. Their research primarily spans oncology, molecular biology, cancer research, pulmonary and respiratory medicine, and immunology.

The main topics covered in their work include:

  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • Radiomics and Machine Learning in Medical Imaging
  • Immunotherapy and Immune Responses
  • Lung Cancer Treatments and Mutations
  • Chronic Lymphocytic Leukemia Research

Several recent papers associated with or related to their research group highlight advances in cancer biology and the tumor microenvironment. These include:

  • The human tumor microbiome is composed of tumor type-specific intracellular bacteria, 2020, Science
  • Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients, 2020, Science
  • Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions, 2022, Cell
  • Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome, 2020, Nature Cancer
  • Fibroblast-Derived IL33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type 2 Immunity, 2020, Cancer Research

Frequent coauthors reflecting close collaboration in research efforts are:

  • Nora Balint-Lahat
  • Einav Nili Gal-Yam
  • Chen Mayer
  • Maya Dadiani
  • Jair Bar

Barshack's publications frequently appear in venues such as Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Journal of Crohn's and Colitis, JCI Insight, and Journal of Clinical Oncology. The highest number of publications are in Cancer Research and bioRxiv.

Best Publications

  • Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.

    Leore T. Geller;Michal Barzily-Rokni;Tal Danino;Oliver H. Jonas;Oliver H. Jonas

  • The human tumor microbiome is composed of tumor type–specific intracellular bacteria

    Deborah Nejman;Ilana Livyatan;Garold Fuks;Nancy Gavert

  • Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

    Erez N. Baruch;Erez N. Baruch;Ilan Youngster;Guy Ben-Betzalel;Rona Ortenberg

  • MicroRNAs accurately identify cancer tissue origin

    Nitzan Rosenfeld;Ranit Aharonov;Eti Meiri;Shai Rosenwald

  • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia.

    Sarah Ferber;Amir Halkin;Hofit Cohen;Idit Ber;Idit Ber

  • Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells

    Tamar Sapir;Keren Shternhall;Irit Meivar-Levy;Tamar Blumenfeld

  • Functional, Persistent, and Extended Liver to Pancreas Transdifferentiation

    Idit Ber;Keren Shternhall;Keren Shternhall;Keren Shternhall;Shira Perl;Zohar Ohanuna;Zohar Ohanuna

  • Immunolocalization of β2-Glycoprotein I (Apolipoprotein H) to Human Atherosclerotic Plaques Potential Implications for Lesion Progression

    Jacob George;Dror Harats;Boris Gilburd;Arnon Afek

  • Lack of Interleukin-1α or Interleukin-1β Inhibits Transformation of Steatosis to Steatohepatitis and Liver Fibrosis in Hypercholesterolemic Mice

    Yehuda Kamari;Aviv Shaish;Einav Vax;Einav Vax;Shay Shemesh;Shay Shemesh

  • Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

    Michal Harel;Rona Ortenberg;Rona Ortenberg;Siva Karthik Varanasi;Kailash Chandra Mangalhara

  • MiR-92b and miR-9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors

    Dvora Nass;Dvora Nass;Shai Rosenwald;Eti Meiri;Shlomit Gilad

  • Allicin inhibits spontaneous and TNF-fN˜induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells

    Alon Lang;Maor Lahav;Emad Sakhnini;Iris Barshack

  • Perioperative COX-2 and β-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial

    Lee Shaashua;Maytal Shabat-Simon;Rita Haldar;Pini Matzner

  • Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome

    Gil Friedman;Oshrat Levi-Galibov;Eyal David;Chamutal Bornstein

  • High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation

    Iris Lavon;Iris Goldberg;Sharon Amit;Limor Landsman

  • Melanoma miRNA trafficking controls tumour primary niche formation

    Shani Dror;Laureen Sander;Hila Schwartz;Danna Sheinboim

  • Effects of Hypoxia-Inducible Factor-1α Overexpression in Pregnant Mice: Possible Implications for Preeclampsia and Intrauterine Growth Restriction

    Reshef Tal;Aviv Shaish;Iris Barshack;Silvia Polak-Charcon

  • Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors.

    Neta Erez;Sarah Glanz;Yael Raz;Yael Raz;Camilla Avivi

  • Mutant p53 R175H upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells

    I. Kogan-Sakin;Y. Tabach;Y. Buganim;A. Molchadsky

  • MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth

    Yael Nemlich;Eyal Greenberg;Eyal Greenberg;Rona Ortenberg;Rona Ortenberg;Michal J. Besser

Frequent Co-Authors

Dror Harats
Dror Harats Sheba Medical Center
Iris Goldberg
Iris Goldberg Sheba Medical Center
Gal Markel
Gal Markel Tel Aviv University
Gideon Rechavi
Gideon Rechavi Sheba Medical Center
Yehuda Shoenfeld
Yehuda Shoenfeld Sheba Medical Center
Eitan Friedman
Eitan Friedman City University of New York
Ninette Amariglio
Ninette Amariglio Sheba Medical Center
Miri Blank
Miri Blank Tel Aviv University
Tamar Geiger
Tamar Geiger Tel Aviv University
Jacob Schachter
Jacob Schachter Sheba Medical Center

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