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Molecular Biology

D-Index
54
Citations
19542
World Ranking
2297
National Ranking
180

Overview

Pascal Meier is affiliated with the Institute of Cancer Research in the United Kingdom. Their research primarily focuses on fields related to biochemistry, genetics, and molecular biology, with 52 publications in these areas. They also contribute to the field of medicine, having 19 publications. Within these broader disciplines, their work is specialized in molecular biology, immunology, oncology, computational theory and mathematics, and genetics.

Their research topics include cell death mechanisms and regulation, interferon and immune responses, PARP inhibition in cancer therapy, computational drug discovery methods, virus-based gene therapy research, phagocytosis and immune regulation, and cell adhesion molecules research. These topics reflect a comprehensive engagement with both fundamental molecular processes and applied therapeutic strategies.

Pascal Meier has published in several leading scientific journals, frequently contributing to Nature Communications and bioRxiv (Cold Spring Harbor Laboratory), each hosting seven of their works. Additional venues where their research appears include Cell Death and Differentiation, Developmental Cell, and eLife.

Recent papers authored or co-authored by Pascal Meier include the following:

  • Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity, 2024, Nature reviews. Cancer
  • Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells, 2020, Cell
  • Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth, 2020, Nature Communications
  • Primidone blocks RIPK1-driven cell death and inflammation, 2020, Cell Death and Differentiation
  • Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance, 2021, Nature Communications

Throughout their career, Pascal Meier has frequently collaborated with a group of co-authors, including Tencho Tenev, Rebecca Wilson, Jyoti S. Choudhary, Victoria Roulstone, and Kevin J. Harrington. These collaborations indicate a sustained working relationship contributing to their research outputs.

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Apoptosis in development

    Pascal Meier;Andrew Finch;Gerard Evan

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer

    Mads Gyrd-Hansen;Pascal Meier

  • The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

    Tencho Tenev;Katiuscia Bianchi;Maurice Darding;Meike Broemer

  • The Drosophila caspase DRONC is regulated by DIAP1.

    Pascal Meier;John Silke;Sally J. Leevers;Gerard I. Evan;Gerard I. Evan;Gerard I. Evan

  • The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

    Rebecca Wilson;Lakshmi Goyal;Mark Ditzel;Anna Zachariou

  • Inhibitor of Apoptosis (IAP) Proteins–Modulators of Cell Death and Inflammation

    John Silke;Pascal Meier

  • IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

    Mads Gyrd-Hansen;Maurice Darding;Maria Miasari;Massimo M. Santoro;Massimo M. Santoro

  • MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

    Isabel Jaco;Alessandro Annibaldi;Najoua Lalaoui;Najoua Lalaoui;Rebecca Wilson

  • Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.

    Mark Ditzel;Rebecca Wilson;Tencho Tenev;Anna Zachariou

  • Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

    Alessandro Annibaldi;Pascal Meier

  • PIMS Modulates Immune Tolerance by Negatively Regulating Drosophila Innate Immune Signaling

    Nouara Lhocine;Paulo S. Ribeiro;Paulo S. Ribeiro;Nicolas Buchon;Alexander Wepf

  • PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

    Brasó-Maristany F;Filosto S;Catchpole S;Marlow R

  • IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms

    Tencho Tenev;Anna Zachariou;Rebecca Wilson;Mark Ditzel

  • Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling

    Nicholas Paquette;Meike Broemer;Kamna Aggarwal;Li Chen

  • SUMO-mediated regulation of NLRP3 modulates inflammasome activity.

    Rachael Barry;Rachael Barry;Sidonie Wicky John;Gianmaria Liccardi;Tencho Tenev

  • A fluorescent reporter of caspase activity for live imaging.

    Pierre-Luc Bardet;Golnar Kolahgar;Anita Mynett;Irene Miguel-Aliaga

  • Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes

    Deniz Ertürk-Hasdemir;Meike Broemer;François Leulier;William S. Lane

  • The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection

    François Leulier;Nouara Lhocine;Bruno Lemaitre;Pascal Meier

Frequent Co-Authors

John Silke
John Silke Walter and Eliza Hall Institute of Medical Research
Gyorgy Szabadkai
Gyorgy Szabadkai University College London
Peter Vandenabeele
Peter Vandenabeele Ghent University
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Carmen Garrido
Carmen Garrido University of Burgundy
Marion MacFarlane
Marion MacFarlane University of Cambridge
Oliver Kepp
Oliver Kepp Institut Gustave Roussy
Catherine Brenner
Catherine Brenner Université Paris Cité
Manolis Pasparakis
Manolis Pasparakis University of Cologne

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