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Nicholas B. La Thangue

Nicholas B. La Thangue

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
18770
World Ranking
11153
National Ranking
856

Research.com Recognitions

  • 2004 - Fellow of the Royal Society of Edinburgh

Overview

Nicholas B. La Thangue is affiliated with the University of Oxford in the United Kingdom. Their research primarily focuses on the intersection of biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology.

The scientist's work concentrates on several key topics, including:

  • Cancer-related gene regulation
  • Epigenetics and DNA Methylation
  • Renal and related cancers

Recent publications from La Thangue include studies on therapeutic approaches targeting pancreatic cancer. Notable papers are:

  • Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors (2023), published in Cell Death and Disease
  • Abstract 2675: Vactosertib combined treatment with T1-44, a PRMT5 activity inhibitor, improves the survival and inhibits tumor invasion of murine pancreatic cancer model (2023), published in Cancer Research

Frequent collaborators in their research include:

  • Sujin Park
  • Seok Hee Park
  • Seong-Jin Kim
  • Eunji Hong
  • Wojciech Barczak

The venues where La Thangue has published reflect their focus area, with works appearing in:

  • Cell Death and Disease
  • Cancer Research

In recognition of their contributions to science, La Thangue was named a Fellow of the Royal Society of Edinburgh in 2004.

Best Publications

  • Selective inhibition of BET bromodomains.

    Panagis Filippakopoulos;Jun Qi;Sarah Picaud;Yao Shen

  • p300/CBP proteins: HATs for transcriptional bridges and scaffolds

    Ho Man Chan;Nicholas B. La Thangue

  • Arginine methylation regulates the p53 response

    Martin Jansson;Stephen T. Durant;Er Chieh Cho;Sharon Sheahan

  • HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

    Omar Khan;Nicholas B La Thangue

  • Chk2 activates E2F-1 in response to DNA damage

    Craig Stevens;Linda Smith;Nicholas B. La Thangue

  • SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

    Sophia X. Pfister;Sara Ahrabi;Lykourgos-Panagiotis Zalmas;Sovan Sarkar

  • DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control.

    Nicholas B. La Thangue

  • Pharmacodynamic Response and Inhibition of Growth of Human Tumor Xenografts by the Novel Histone Deacetylase Inhibitor PXD101

    Jane A Plumb;Paul W Finn;Robert J Williams;Morwenna J Bandara

  • HDAC inhibitor-based therapies: Can we interpret the code?

    Maria New;Heidi Olzscha;Nicholas B. La Thangue

  • A new component of the transcription factor DRTF1/E2F

    R Girling;J F Partridge;J F Partridge;L R Bandara;N Burden

  • Predictive biomarkers: a paradigm shift towards personalized cancer medicine.

    Nicholas B. La Thangue;David J. Kerr

  • A novel cofactor for p300 that regulates the p53 response.

    Noriko Shikama;Chang Woo Lee;Laurent Delavaine

  • Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.

    Sophia X. Pfister;Enni Markkanen;Yanyan Jiang;Sovan Sarkar

  • p53-cofactor JMY is a multifunctional actin nucleation factor

    J. Bradley Zuchero;Amanda S. Coutts;Margot E. Quinlan;Nicholas B. La Thangue

  • E2F and cell cycle control: a double-edged sword.

    Craig Stevens;Nicholas B La Thangue

  • Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

    Sarah Picaud;Sarah Picaud;Oleg Fedorov;Oleg Fedorov;Angeliki Thanasopoulou;Katharina Leonards

  • Arginine methylation controls growth regulation by E2F-1

    Er Chieh Cho;Shunsheng Zheng;Shonagh Munro;Geng Liu

  • Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators.

    N Shikama;H M Chan;M Krstic-Demonacos;L Smith

  • Histone deacetylase inhibitors open new doors in cancer therapy.

    Fiona McLaughlin;Nicholas B La Thangue

  • HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy

    Omar Khan;Susan Fotheringham;Victoria Wood;Lindsay Stimson

Frequent Co-Authors

Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Oleg Fedorov
Oleg Fedorov University of Oxford
David J. Kerr
David J. Kerr University of Oxford
Maria I. New
Maria I. New Icahn School of Medicine at Mount Sinai
Panagis Filippakopoulos
Panagis Filippakopoulos Structural Genomics Consortium
René Bernards
René Bernards Antoni van Leeuwenhoek Hospital
Peter W. J. Rigby
Peter W. J. Rigby Institute of Cancer Research
Susanne Müller
Susanne Müller Structural Genomics Consortium
Mark T. Bedford
Mark T. Bedford The University of Texas MD Anderson Cancer Center

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