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Michael Schaefer

Michael Schaefer

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
15325
World Ranking
10696
National Ranking
772

Overview

Michael Schaefer is affiliated with Leipzig University in Germany and has conducted extensive research primarily within the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Their work spans multiple subfields, including Molecular Biology, Sensory Systems, Cellular and Molecular Neuroscience, Physiology, and Nutrition and Dietetics.

The research topics frequently addressed by Schaefer include Ion Channels and Receptors, Neurobiology and Insect Physiology Research, Calcium signaling and nucleotide metabolism, Cellular transport and secretion, Photochromic and Fluorescence Chemistry, Phytochemicals and Antioxidant Activities, and Herbal Medicine Research Studies.

Schaffer has published numerous scientific articles, with some notable recent papers as follows:

  • Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function (2020, eLife)
  • Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth (2021, Cell Chemical Biology)
  • Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors (2021, Scientific Reports)
  • Restoration of MARCK enhances chemosensitivity in cancer (2020, Journal of Cancer Research and Clinical Oncology)
  • Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3 (2020, European Journal of Medicinal Chemistry)

Their work is published frequently in scientific journals such as Cell Calcium, Journal of Cancer Research and Clinical Oncology, Scientific Reports, British Journal of Pharmacology, and International Journal of Molecular Sciences.

Michael Schaefer's frequent collaborators include Nicole Urban, Kerstin Hill, Franz Bracher, Hermann Kalwa, and Ute Krügel. These collaborations have contributed to a significant body of research output.

Best Publications

  • Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.

    Thomas Hofmann;Alexander G. Obukhov;Michael Schaefer;Christian Harteneck

  • Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells

    Annabell Bachem;Steffen Güttler;Evelyn Hartung;Frédéric Ebstein

  • Subunit composition of mammalian transient receptor potential channels in living cells

    Thomas Hofmann;Michael Schaefer;Günter Schultz;Thomas Gudermann

  • Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8+ T Cells

    Brigitte G. Dorner;Martin B. Dorner;Xuefei Zhou;Corinna Opitz

  • Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5.

    Michael Schaefer;Timothy D. Plant;Alexander G. Obukhov;Thomas Hofmann

  • Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.

    Manuela Rossol;Matthias Pierer;Nora Raulien;Dagmar Quandt

  • GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

    Lisa-Marie Munter;Philipp Voigt;Anja Harmeier;Daniela Kaden

  • Homo- and heteromeric assembly of TRPV channel subunits.

    Nicole Hellwig;Nadine Albrecht;Christian Harteneck;Günter Schultz

  • Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ

    Carsten Brock;Carsten Brock;Michael Schaefer;H. Peter Reusch;Cornelia Czupalla;Cornelia Czupalla

  • Lanthanides Potentiate TRPC5 Currents by an Action at Extracellular Sites Close to the Pore Mouth

    Silke Jung;Anja Mühle;Michael Schaefer;Rainer Strotmann

  • Reversible photobleaching of enhanced green fluorescent proteins.

    Daniel Sinnecker;Philipp Voigt;Nicole Hellwig;Michael Schaefer

  • TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels

    Tim D. Plant;Michael Schaefer

  • Human TRPV4 Channel Splice Variants Revealed a Key Role of Ankyrin Domains in Multimerization and Trafficking

    Maite Arniges;José M. Fernández-Fernández;Nadine Albrecht;Michael Schaefer

  • Regulation of Raf by Akt Controls Growth and Differentiation in Vascular Smooth Muscle Cells

    H. Peter Reusch;Sven Zimmermann;Michael Schaefer;Martin Paul

  • Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from β-cells through activation of GPR40

    Susanne Schnell;Michael Schaefer;Christof Schöfl

  • Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.

    Stefan Wüller;Burkhard Wiesner;Anja Löffler;Jens Furkert

  • Transient receptor potential channels as molecular substrates of receptor-mediated cation entry.

    Thomas Hofmann;Michael Schaefer;Günter Schultz;Thomas Gudermann

  • Homo- and heteromeric assembly of TRP channel subunits

    Michael Schaefer

  • Ligand-dependent Differences in the Internalization of Endothelin A and Endothelin B Receptor Heterodimers

    Bernd Gregan;Jana Jürgensen;Gisela Papsdorf;Jens Furkert

  • TRPV1 Acts as Proton Channel to Induce Acidification in Nociceptive Neurons

    Nicole Hellwig;Tim D. Plant;Wiebke Janson;Michael Schäfer

Frequent Co-Authors

Christoph Stein
Christoph Stein Charité - University Medicine Berlin
Thomas Gudermann
Thomas Gudermann Ludwig-Maximilians-Universität München
Günter Schultz
Günter Schultz Freie Universität Berlin
Gerd Multhaup
Gerd Multhaup McGill University
Burghardt Wittig
Burghardt Wittig Freie Universität Berlin
Bernd Nürnberg
Bernd Nürnberg University of Tübingen
Walter Rosenthal
Walter Rosenthal Freie Universität Berlin
Enno Klussmann
Enno Klussmann Max Delbrück Center for Molecular Medicine
Andreas Heinz
Andreas Heinz Charité - University Medicine Berlin
Christian Harteneck
Christian Harteneck University of Tübingen

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