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D-Index & Metrics

Microbiology

D-Index
73
Citations
24097
World Ranking
1630
National Ranking
700

Overview

Lee A. Denson is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research contributions focus primarily on the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Within these main areas, their work covers significant subfields such as Genetics, Surgery, Epidemiology, Immunology, and Molecular Biology.

The scientist's research is concentrated around key topics including:

  • Inflammatory Bowel Disease
  • Microscopic Colitis
  • Gut microbiota and health
  • Helicobacter pylori-related gastroenterology studies
  • IL-33, ST2, and ILC Pathways
  • Pancreatitis Pathology and Treatment
  • Digestive system and related health

Lee A. Denson has published extensively, with a strong presence in prominent journals. The most frequent publication venues include:

  • Gastroenterology
  • Inflammatory Bowel Diseases
  • Journal of Crohn's and Colitis
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Pediatric Gastroenterology and Nutrition

Recent papers authored by Lee A. Denson encompass crucial topics in gastroenterology and genetics, featuring studies that explore the mechanisms and biomarkers of inflammatory bowel diseases. Selected recent publications are:

  • "Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease," 2020, Gastroenterology
  • "Microbiota-derived metabolite promotes HDAC3 activity in the gut," 2020, Nature
  • "Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis," 2020, Gastroenterology
  • "Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries," 2023, Nature Genetics
  • "Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives," 2023, Gastroenterology

Throughout their career, Lee A. Denson has collaborated frequently with several researchers, including:

  • Jeffrey S. Hyams
  • Subra Kugathasan
  • Phillip Minar
  • Anne M. Griffiths
  • Yael Haberman

Best Publications

  • The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

    Dirk Gevers;Subra Kugathasan;Lee A. Denson;Yoshiki Vázquez-Baeza

  • Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.

    Jason Lloyd-Price;Jason Lloyd-Price;Cesar Arze;Ashwin N. Ananthakrishnan;Melanie Schirmer;Melanie Schirmer

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Carl A. Anderson;Gabrielle Boucher;Charlie W. Lees;Andre Franke

  • Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.

    Jerome C. Martin;Christie Chang;Gilles Boschetti;Ryan Ungaro

  • Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

    Subra Kugathasan;Lee A. Denson;Thomas D. Walters;Mi Ok Kim

  • Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease.

    Michael R. Konikoff;Lee A. Denson

  • Common variants at five new loci associated with early-onset inflammatory bowel disease.

    Marcin Imielinski;Robert N. Baldassano;Anne Griffiths;Richard K. Russell

  • Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

    Yael Haberman;Timothy L. Tickle;Phillip J. Dexheimer;Mi-Ok Kim

  • Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

    Melanie Schirmer;Melanie Schirmer;Eric A. Franzosa;Eric A. Franzosa;Jason Lloyd-Price;Jason Lloyd-Price;Lauren J. McIver;Lauren J. McIver

  • The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.

    Lee A. Denson;Ekkehard Sturm;Wihelma Echevarria;Tracy L. Zimmerman

  • Association of host genome with intestinal microbial composition in a large healthy cohort

    Williams Turpin;Osvaldo Espin-Garcia;Wei Xu;Mark S Silverberg;Mark S Silverberg;Mark S Silverberg

  • Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

    Subra Kugathasan;Robert N Baldassano;Jonathan P Bradfield;Patrick M A Sleiman

  • Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

    Yael Haberman;Yael Haberman;Rebekah Karns;Phillip J. Dexheimer;Melanie Schirmer

  • GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis.

    Kanji Uchida;David C. Beck;Takashi Yamamoto;Pierre-Yves Berclaz

  • Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.

    Kai Wang;Haitao Zhang;Subra Kugathasan;Vito Annese

  • High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

    Philippe Goyette;Gabrielle Boucher;Dermot Mallon;Eva Ellinghaus

  • Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs an immunomodulator in children with Crohn's disease.

    Thomas D. Walters;Mi Ok Kim;Lee A. Denson;Anne M. Griffiths

  • Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course.

    Melanie Schirmer;Melanie Schirmer;Lee Denson;Hera Vlamakis;Hera Vlamakis;Hera Vlamakis;Eric A. Franzosa;Eric A. Franzosa

  • Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

    Yun R Li;Jin Li;Sihai D Zhao;Sihai D Zhao;Jonathan P Bradfield

  • Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease.

    Williams Turpin;Williams Turpin;Sun-Ho Lee;Sun-Ho Lee;Juan Antonio Raygoza Garay;Juan Antonio Raygoza Garay;Karen L. Madsen

  • ImproveCareNow: The development of a pediatric inflammatory bowel disease improvement network

    Wallace Crandall;Mph Michael D. Kappelman Md;Richard B. Colletti;Ian Leibowitz

  • Interleukin-1β Suppresses Retinoid Transactivation of Two Hepatic Transporter Genes Involved in Bile Formation

    Lee A. Denson;Kathryn L. Auld;Dagmar S. Schiek;Mitchell H. McClure

  • Microbiota-derived metabolite promotes HDAC3 activity in the gut

    Shu-en Wu;Seika Hashimoto-Hill;Vivienne Woo;Emily M. Eshleman

Frequent Co-Authors

Subra Kugathasan
Subra Kugathasan Emory University
Robert N. Baldassano
Robert N. Baldassano Children's Hospital of Philadelphia
Jeffrey S. Hyams
Jeffrey S. Hyams University of Connecticut
Anne M. Griffiths
Anne M. Griffiths University of Toronto
David R. Mack
David R. Mack University of Ottawa
Marla Dubinsky
Marla Dubinsky Icahn School of Medicine at Mount Sinai
Kevin A. Hommel
Kevin A. Hommel Cincinnati Children's Hospital Medical Center
Ramnik J. Xavier
Ramnik J. Xavier Broad Institute
Bruce J. Aronow
Bruce J. Aronow Cincinnati Children's Hospital Medical Center
Bruce C. Trapnell
Bruce C. Trapnell Cincinnati Children's Hospital Medical Center

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