D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Molecular Biology D-index 93 Citations 43,022 211 World Ranking 391 National Ranking 227

Research.com Recognitions

Awards & Achievements

1995 - Member of the National Academy of Sciences

1995 - Promega Biotechnology Research Award, American Society for Microbiology

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

Larry Gold mainly investigates Systematic evolution of ligands by exponential enrichment, Biochemistry, Nucleic acid, Computational biology and Genetics. His Systematic evolution of ligands by exponential enrichment study is associated with RNA. His work in Biochemistry addresses issues such as Ligand, which are connected to fields such as Molecule.

His Nucleic acid research is multidisciplinary, incorporating perspectives in Polymerase, DNA, Ligand, Nucleotide and Combinatorial chemistry. His Polymerase study incorporates themes from Nucleic acid structure, Transcription, Drug discovery and DNA polymerase. His Computational biology research incorporates themes from Proteomics, Molecular biology, Aptamer, Complementarity and Stereochemistry.

His most cited work include:

  • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase (7416 citations)
  • Information content of binding sites on nucleotide sequences (830 citations)
  • Aptamer-based multiplexed proteomic technology for biomarker discovery (796 citations)

What are the main themes of his work throughout his whole career to date?

Larry Gold mostly deals with Biochemistry, Nucleic acid, Systematic evolution of ligands by exponential enrichment, Molecular biology and RNA. His Oligonucleotide, Binding site, Tenascin C and Enzyme study, which is part of a larger body of work in Biochemistry, is frequently linked to Identification, bridging the gap between disciplines. His research in Nucleic acid focuses on subjects like Molecule, which are connected to Covalent bond.

He combines subjects such as Computational biology, DNA, Aptamer and Nucleotide with his study of Systematic evolution of ligands by exponential enrichment. His biological study spans a wide range of topics, including Bacteriophage, Transcription, Messenger RNA, Gene and Cell biology. His RNA research integrates issues from Consensus sequence and Virology.

He most often published in these fields:

  • Biochemistry (34.56%)
  • Nucleic acid (31.21%)
  • Systematic evolution of ligands by exponential enrichment (29.53%)

What were the highlights of his more recent work (between 2006-2020)?

  • Aptamer (11.41%)
  • Computational biology (14.77%)
  • Proteomics (7.38%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Aptamer, Computational biology, Proteomics, Biomarker discovery and Bioinformatics. His Aptamer research is multidisciplinary, relying on both Combinatorial chemistry, Molecule, Nucleic acid and Systematic evolution of ligands by exponential enrichment. Nucleic acid is the subject of his research, which falls under Biochemistry.

His studies in Computational biology integrate themes in fields like Genetics, SELEX Aptamer Technique, Proteomics methods and Human proteome project. His Proteomics research includes elements of Proteome, Disease, Cohort, Pathology and DNA microarray. He has researched Biomarker discovery in several fields, including Multiplex, Microarray, Molecular biology, Serum protein and Lung cancer.

Between 2006 and 2020, his most popular works were:

  • Aptamer-based multiplexed proteomic technology for biomarker discovery (796 citations)
  • Aptamer-based multiplexed proteomic technology for biomarker discovery (242 citations)
  • Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents. (241 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

Craig Tuerk;Larry Gold.
Science (1990)

13438 Citations

Aptamer-based multiplexed proteomic technology for biomarker discovery

Larry Gold;Deborah Ayers;Jennifer Bertino;Christopher Bock.
PLOS ONE (2010)

1539 Citations

Information content of binding sites on nucleotide sequences

Thomas D. Schneider;Gary D. Stormo;Larry Gold;Andrzej Ehrenfeucht.
Journal of Molecular Biology (1986)

1260 Citations

Methods for identifying nucleic acid ligands

Larry Gold;Craig Tuerk.
(1992)

1240 Citations

Nucleic acid ligands

Larry Gold;Craig Tuerk.
(1991)

1219 Citations

Diversity of Oligonucleotide Functions

Larry Gold;Barry Polisky;Olke Uhlenbeck;Michael Yarus.
Annual Review of Biochemistry (1995)

1153 Citations

Posttranscriptional regulatory mechanisms in Escherichia coli.

Larry Gold.
Annual Review of Biochemistry (1988)

955 Citations

Translational Initiation in Prokaryotes

L. Gold;D. Pribnow;T. Schneider;S. Shinedling.
Annual Review of Microbiology (1981)

923 Citations

Aptamers as therapeutic and diagnostic agents

Edward N. Brody;Larry Gold.
Reviews in Molecular Biotechnology (2000)

851 Citations

Use of the ‘Perceptron’ algorithm to distinguish translational initiation sites in E. coli

Gary D. Stormo;Thomas D. Schneider;Larry Gold;Andrzej Ehrenfeucht.
Nucleic Acids Research (1982)

841 Citations

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