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Immunology

D-Index
42
Citations
12528
World Ranking
4866
National Ranking
2178

Overview

Jane L. Grogan is affiliated with Biogen in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Oncology, Immunology, Molecular Biology, Genetics, and Plant Science as notable subfields of study.

The scientist's work concentrates on topics including CAR-T cell therapy research, Immune Cell Function and Interaction, Cancer Immunotherapy and Biomarkers, CRISPR and Genetic Engineering, Immune cells in cancer, RNA and protein synthesis mechanisms, and Virus-based gene therapy research.

Jane L. Grogan has contributed to multiple publications, with recent notable papers as follows:

  • Peripheral T cell expansion predicts tumour infiltration and clinical response, 2020, Nature
  • High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade, 2020, Nature Medicine
  • Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer, 2022, Cancer Cell
  • Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses, 2022, Immunity
  • Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade, 2021, Journal for ImmunoTherapy of Cancer

The scientist frequently publishes in the following venues:

  • European Journal of Immunology
  • Nature Medicine
  • Cancer Research
  • Nature Communications
  • Nature

Frequent co-authors who have collaborated on multiple publications with Jane L. Grogan include:

  • Avantika S. Chitre
  • Sophie Brouard
  • Dirk H. Busch
  • Andrea Cossarizza
  • Günnur Deniz

Best Publications

  • The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

    Xin Yu;Kristin Harden;Lino C Gonzalez;Michelle Francesco

  • The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function

    Robert J. Johnston;Laetitia Comps-Agrar;Jason Hackney;Xin Yu

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC + CD127 + natural killer–like cells

    Tom Cupedo;Natasha K Crellin;Natalie Papazian;Elwin J Rombouts

  • Peripheral T cell expansion predicts tumour infiltration and clinical response

    Thomas D. Wu;Shravan Madireddi;Patricia E. de Almeida;Romain Banchereau

  • T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function

    Max Löhning;Arne Stroehmann;Anthony J. Coyle;Jane L. Grogan

  • Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

    Jane L. Grogan;Markus Mohrs;Brian Harmon;Dee A. Lacy

  • Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses

    Unknown

  • TIGIT: A Key Inhibitor of the Cancer Immunity Cycle.

    Nicholas A. Manieri;Eugene Y. Chiang;Jane L. Grogan

  • High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.

    Kobe C. Yuen;Li-Fen Liu;Vinita Gupta;Shravan Madireddi

  • Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

    Janet Lau;Jeanne Cheung;Armando Navarro;Steve Lianoglou

  • Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer

    Unknown

  • Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease.

    Eugene Y Chiang;Ganesh A Kolumam;Xin Yu;Michelle Francesco

  • Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell–cell adhesion and signaling mechanism that requires cis-trans receptor clustering

    Katharina F. Stengel;Kristin Harden-Bowles;Xin Yu;Lionel Rouge

  • TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers

    X Yu;R Pappu;V Ramirez-Carrozzi;N Ota

  • Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.

    Stephen J. Davies;Jane L. Grogan;Rebecca B. Blank;K. C. Lim

  • T helper cell differentiation: on again, off again

    Jane L Grogan;Richard M Locksley

  • CD30 expression does not discriminate between human Th1- and Th2-type T cells.

    D. Hamann;C. M. U. Hilkens;J. L. Grogan;S. M. A. Lens

  • Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.

    Romain Banchereau;Avantika S. Chitre;Alexis Scherl;Thomas D. Wu

  • Antigen-Specific Proliferation and Interferon-γ and Interleukin-5 Production Are Down-Regulated during Schistosoma haematobium Infection

    Jane L. Grogan;Peter G. Kremsner;André M. Deelder;Maria Yazdanbakhsh

  • Elevated proliferation and interleukin-4 release from CD4+ cells after chemotherapy in human Schistosoma haematobium infection

    Jane L. Grogan;Peter G. Kremsner;Peter G. Kremsner;Andre M. Deelder;Maria Yazdanbakhsh

  • CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.

    Hélène Bour-Jordan;Jane L. Grogan;Qizhi Tang;Qizhi Tang;Julie A. Auger

Frequent Co-Authors

Dan L. Eaton
Dan L. Eaton Genentech
Maria Yazdanbakhsh
Maria Yazdanbakhsh Leiden University Medical Center
Peter G. Kremsner
Peter G. Kremsner University of Tübingen
Zora Modrusan
Zora Modrusan Genentech
Wenjun Ouyang
Wenjun Ouyang Amgen (United States)
Ira Mellman
Ira Mellman Parker Institute for Cancer Immunotherapy
Jenny Mjösberg
Jenny Mjösberg Karolinska Institute
Simon Fillatreau
Simon Fillatreau Université Paris Cité
Andreas Radbruch
Andreas Radbruch German Rheumatism Research Centre

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