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James R. Smiley

James R. Smiley

D-Index & Metrics

Microbiology

D-Index
49
Citations
15807
World Ranking
4514
National Ranking
128

Overview

James R. Smiley is affiliated with the University of Alberta in Canada. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Agricultural and Biological Sciences. The scientist has contributed to various subfields such as Genetics, Infectious Diseases, and Animal Science and Zoology.

The main topics addressed in their work include virus-based gene therapy research, viral gastroenteritis research and epidemiology, and animal virus infections studies. These focus areas highlight a cross-disciplinary approach, integrating molecular biology with clinical and veterinary aspects of viral infections.

Among their recent publications, one prominent paper is titled "Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding σ3 respectively," published in 2020 in PLoS Pathogens.

Frequent co-authors in their research collaborations include Adil Mohamed, Prathyusha Konda, Heather E. Eaton, Shashi Gujar, and Maya Shmulevitz. These collaborators indicate an active engagement with a network of researchers in related virus and host response studies.

Publication venues predominantly feature PLoS Pathogens, reflecting a focus on microbial pathogenesis and host-virus interactions.

Best Publications

  • Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

    F. L. Graham;J. Smiley;W. C. Russell;R. Nairn

  • Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response

    A. Phillip West;William Khoury-Hanold;Matthew Staron;Michal C. Tal

  • The interferon response inhibits HIV particle production by induction of TRIM22.

    Stephen D. Barr;James R. Smiley;Frederic D. Bushman

  • Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response

    Karen L. Mossman;Pascale F. Macgregor;Jacob J. Rozmus;Andrew B. Goryachev

  • Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase?

    James R. Smiley

  • Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon

    Karen L. Mossman;Holly A. Saffran;James R. Smiley

  • Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs.

    C A Smibert;B Popova;P Xiao;J P Capone

  • Signals for site-specific cleavage of HSV DNA: maturation involves two separate cleavage events at sites distal to the recognition sequences

    Susannah L. Varmuza;James R. Smiley

  • Evidence that Herpes Simplex Virus VP16 Is Required for Viral Egress Downstream of the Initial Envelopment Event

    Karen L. Mossman;Richard Sherburne;Carol Lavery;Joanne Duncan

  • Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2.

    M R McDermott;J R Smiley;P Leslie;J Brais

  • Construction and characterization of a recombinant plasmid encoding the gene for the thymidine kinase of Herpes simplex type 1 virus.

    Lynn W. Enquist;George F. Vande Woude;Michael Wagner;James R. Smiley

  • Herpes simplex virus eliminates host mitochondrial DNA.

    Holly A Saffran;Justin M Pare;Jennifer A Corcoran;Sandra K Weller

  • Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function.

    Q Lam;C A Smibert;K E Koop;C Lavery

  • The Herpes Simplex Virus vhs Protein Induces Endoribonucleolytic Cleavage of Target RNAs in Cell Extracts

    Mabrouk M. Elgadi;Christopher E. Hayes;James R. Smiley;James R. Smiley

  • Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication.

    Karen L. Mossman;James R. Smiley

  • Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41.

    Craig A. Smibert;David C. Johnson;James R. Smiley

  • Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.

    B Panning;J R Smiley

  • Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins.

    F E Jones;C A Smibert;J R Smiley

  • Cells expressing herpes simplex virus glycoprotein gC but not gB, gD, or gE are recognized by murine virus-specific cytotoxic T lymphocytes.

    K L Rosenthal;J R Smiley;S South;D C Johnson

  • Construction of a double-jointed herpes simplex viral DNA molecule: inverted repeats are required for segment inversion, and direct repeats promote deletions.

    James R. Smiley;Bessie S. Fong;Wai-Choi Leung

  • Herpes Simplex Virus ICP0 Mutants Are Hypersensitive

    Karen L. Mossman;Holly A. Saffran;James R. Smiley

Frequent Co-Authors

Karen L. Mossman
Karen L. Mossman McMaster University
David C. Johnson
David C. Johnson Oregon Health & Science University
Silvia Bacchetti
Silvia Bacchetti McMaster University
Frank L. Graham
Frank L. Graham McMaster University
Susan M. Kaech
Susan M. Kaech Salk Institute for Biological Studies
Roger D. Everett
Roger D. Everett University of Glasgow
Jerry Pelletier
Jerry Pelletier McGill University
Ian Mohr
Ian Mohr New York University
Akiko Iwasaki
Akiko Iwasaki Yale University
Frederic D. Bushman
Frederic D. Bushman University of Pennsylvania

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