D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 49 Citations 10,960 117 World Ranking 10933 National Ranking 4738

Research.com Recognitions

Awards & Achievements

2011 - National Institutes of Health Director's Pioneer Award

2008 - Member of the National Academy of Medicine (NAM)

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Immune system
  • Antibody

James E. K. Hildreth mostly deals with Virology, Virus, Biochemistry, Lipid raft and Antibody. He combines subjects such as Macrophage, Cell and CTL* with his study of Virology. His biological study spans a wide range of topics, including Cell fusion and Major histocompatibility complex.

His work on Glycoprotein, Membrane and Dialysis as part of general Biochemistry study is frequently linked to Glucoside, therefore connecting diverse disciplines of science. The study incorporates disciplines such as Transmembrane protein, Peripheral membrane protein, Ganglioside and Cell biology in addition to Lipid raft. In his research, Molecular biology, Lymphocyte function-associated antigen 1 and Cytotoxic T cell is intimately related to Antigen, which falls under the overarching field of Antibody.

His most cited work include:

  • Evidence for Budding of Human Immunodeficiency Virus Type 1 Selectively from Glycolipid-Enriched Membrane Lipid Rafts (698 citations)
  • The Trojan exosome hypothesis. (457 citations)
  • Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane (432 citations)

What are the main themes of his work throughout his whole career to date?

James E. K. Hildreth mainly focuses on Virology, Molecular biology, Virus, Antibody and Monoclonal antibody. His Virology study incorporates themes from Lipid raft, Peripheral blood mononuclear cell and Cell biology. His Lipid raft research incorporates themes from Transfection and Endosome.

His Molecular biology study integrates concerns from other disciplines, such as T cell, Cell culture, In vitro and Antigen. In his work, Syncytium is strongly intertwined with Cell fusion, which is a subfield of Virus. His Antibody study combines topics from a wide range of disciplines, such as Transmission and Immune system.

He most often published in these fields:

  • Virology (50.00%)
  • Molecular biology (36.96%)
  • Virus (34.78%)

What were the highlights of his more recent work (between 2012-2021)?

  • Virology (50.00%)
  • Immunology (19.57%)
  • Virus (34.78%)

In recent papers he was focusing on the following fields of study:

James E. K. Hildreth mainly investigates Virology, Immunology, Virus, Proinflammatory cytokine and Viral replication. His work in the fields of Virology, such as Zidovudine, overlaps with other areas such as Placenta. His research investigates the connection between Virus and topics such as Sexual transmission that intersect with issues in Gammaretrovirus.

His Viral replication research incorporates elements of Ex vivo and Cell. His studies in Pseudotyping integrate themes in fields like Xenotropic murine leukemia virus-related virus, Transmission, Coinfection, Tissue tropism and Antibody. James E. K. Hildreth studied In vivo and T cell that intersect with Copurification, Actin, Cell type, Centrifugation and Molecular biology.

Between 2012 and 2021, his most popular works were:

  • Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation. (123 citations)
  • The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types. (49 citations)
  • Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann–Pick C1 mutant cell via lysosome-associated membrane protein 1 (14 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Immune system
  • Antibody

Immunology, Cell culture, T cell, Virus and Viral replication are his primary areas of study. His study in Cell culture is interdisciplinary in nature, drawing from both Infectivity, Microbiology and Cell biology. The various areas that James E. K. Hildreth examines in his T cell study include Receptor, CD36, Monocyte, Proinflammatory cytokine and In vivo.

His Virus research is classified as research in Virology. His work deals with themes such as Cell and Ex vivo, which intersect with Virology. His Viral replication research includes elements of Xenotropic murine leukemia virus-related virus, Tropism, Tissue tropism and Sexual transmission.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Evidence for Budding of Human Immunodeficiency Virus Type 1 Selectively from Glycolipid-Enriched Membrane Lipid Rafts

Dzung H. Nguyen;James E. K. Hildreth.
Journal of Virology (2000)

1096 Citations

The Trojan exosome hypothesis.

Stephen J. Gould;Amy M. Booth;James E. K. Hildreth.
Proceedings of the National Academy of Sciences of the United States of America (2003)

698 Citations

Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane

Amy M. Booth;Yi Fang;Jonathan K. Fallon;Jr-Ming Yang.
Journal of Cell Biology (2006)

573 Citations

Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1.

Zhaohao Liao;Lisa M. Cimakasky;Richard Hampton;Dzung H. Nguyen.
AIDS Research and Human Retroviruses (2001)

468 Citations

A human lymphocyte‐associated antigen involved in cell‐mediated lympholysis

James E. K. Hildreth;Frances M. Gotch;Phyllis D. K. Hildreth;Andrew J. McMichael.
European Journal of Immunology (1983)

464 Citations

Evidence That HIV Budding in Primary Macrophages Occurs through the Exosome Release Pathway

Deborah Greene Nguyen;Amy Booth;Stephen J. Gould;James E.K. Hildreth.
Journal of Biological Chemistry (2003)

435 Citations

Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation.

James E. K. Hildreth;Rimas J. Orentas.
Science (1989)

341 Citations

Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages.

Deborah Greene Nguyen;James E K Hildreth.
European Journal of Immunology (2003)

333 Citations

Actin-Dependent Receptor Colocalization Required for Human Immunodeficiency Virus Entry into Host Cells

Sujatha Iyengar;James E. K. Hildreth;David H. Schwartz.
Journal of Virology (1998)

279 Citations

N-D-Gluco-N-methylalkanamide compounds, a new class of non-ionic detergents for membrane biochemistry.

James E. K. Hildreth.
Biochemical Journal (1982)

245 Citations

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