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Hugo Mouquet

Hugo Mouquet

D-Index & Metrics

Immunology

D-Index
65
Citations
23567
World Ranking
2804
National Ranking
121

Overview

Hugo Mouquet is affiliated with the Institut Pasteur in France and has an extensive research portfolio primarily centered on infectious diseases, immunology, and molecular biology with a strong focus on SARS-CoV-2 and COVID-19 research. Mouquet's work spans multiple interconnected fields, including medicine, immunology and microbiology, infectious diseases, virology, epidemiology, and molecular biology.

The scientist's recent publications highlight investigations into SARS-CoV-2 variants and immune response mechanisms. Notable papers include:

  • Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization, 2021, Nature
  • Considerable escape of SARS-CoV-2 Omicron to antibody neutralization, 2021, Nature
  • Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies, 2021, Nature Medicine
  • Syncytia formation by SARS-CoV-2-infected cells, 2020, The EMBO Journal
  • Syncytia formation by SARS-CoV-2-infected cells, 2021, The EMBO Journal

Mouquet has collaborated frequently with several researchers, which include Cyril Planchais, Olivier Schwartz, Timothée Bruel, Delphine Planas, and Isabelle Staropoli. These collaborations reflect an active engagement in scientific networks focusing on immunology and viral pathogenesis.

Mouquet's publication record shows a preference for disseminating findings in recognized scientific journals and preprint servers. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nature, Cell Host & Microbe, and iScience.

The main research topics embodied in Mouquet's work encompass:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Immune Cell Function and Interaction
  • SARS-CoV-2 detection and testing
  • HIV Research and Treatment
  • T-cell and B-cell Immunology
  • Monoclonal and Polyclonal Antibodies Research

Mouquet's contributions are positioned at the intersection of clinical and experimental immunology, focusing on how immune systems respond to viral infections and how antibody neutralization varies with evolving SARS-CoV-2 variants. The research has implications for understanding viral escape mechanisms and immune protection, key to therapeutic and vaccine strategies.

Best Publications

  • Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

    Unknown

  • Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.

    Delphine Planas;David Veyer;Artem Baidaliuk;Isabelle Staropoli

  • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.

    Johannes F. Scheid;Hugo Mouquet;Beatrix Ueberheide;Ron Diskin

  • Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

    Johannes F. Scheid;Hugo Mouquet;Niklas Feldhahn;Michael S. Seaman

  • Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies.

    Delphine Planas;Delphine Planas;Timothée Bruel;Timothée Bruel;Ludivine Grzelak;Florence Guivel-Benhassine;Florence Guivel-Benhassine

  • Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.

    Hugo Mouquet;Louise Scharf;Zelda Euler;Yan Liu

  • Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

    Florian Klein;Ron Diskin;Ron Diskin;Johannes F. Scheid;Johannes F. Scheid;Christian Gaebler;Christian Gaebler

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

    Florian Klein;Ariel Halper-Stromberg;Joshua A. Horwitz;Henning Gruell;Henning Gruell

  • Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

    Masashi Shingai;Yoshiaki Nishimura;Florian Klein;Hugo Mouquet

  • Antibodies in HIV-1 Vaccine Development and Therapy

    Florian Klein;Hugo Mouquet;Pia Dosenovic;Johannes F. Scheid

  • Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

    Unknown

  • A Single Cycle of Rituximab for the Treatment of Severe Pemphigus

    Pascal Joly;Hugo Mouquet;Jean-Claude Roujeau;Michel D'Incan

  • Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

    Marina Caskey;Till Schoofs;Henning Gruell;Allison Settler

  • Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

    Hugo Mouquet;Johannes F. Scheid;Johannes F. Scheid;Markus J. Zoller;Michelle Krogsgaard

  • Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

    Guillaume Darrasse-Jèze;Stephanie Deroubaix;Hugo Mouquet;Gabriel D. Victora

  • Syncytia formation by SARS-CoV-2-infected cells.

    Julian Buchrieser;Julian Buchrieser;Jérémy Dufloo;Jérémy Dufloo;Jérémy Dufloo;Mathieu Hubert;Mathieu Hubert;Blandine Monel;Blandine Monel

  • Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

    Masashi Shingai;Olivia K. Donau;Ronald J. Plishka;Alicia Buckler-White

  • AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

    Matthew R. Gardner;Lisa M. Kattenhorn;Hema R. Kondur;Markus von Schaewen

  • HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

    Joshua A. Horwitz;Ariel Halper-Stromberg;Hugo Mouquet;Alexander D. Gitlin

  • A method for identification of HIV gp140 binding memory B cells in human blood.

    Johannes F. Scheid;Hugo Mouquet;Niklas Feldhahn;Bruce D. Walker

  • A comparison of four serological assays for detecting anti-SARS-CoV-2 antibodies in human serum samples from different populations.

    Ludivine Grzelak;Ludivine Grzelak;Sarah Temmam;Cyril Planchais;Caroline Demeret

Frequent Co-Authors

Olivier Schwartz
Olivier Schwartz Université Paris Cité
Michel C. Nussenzweig
Michel C. Nussenzweig Rockefeller University
Pamela J. Bjorkman
Pamela J. Bjorkman California Institute of Technology
Michael S. Seaman
Michael S. Seaman Beth Israel Deaconess Medical Center
Sylvie van der Werf
Sylvie van der Werf Université Paris Cité
James P. Di Santo
James P. Di Santo Institut Pasteur
Darragh Duffy
Darragh Duffy Institut Pasteur
Pierre Charneau
Pierre Charneau Institut Pasteur
Arnaud Fontanet
Arnaud Fontanet Institut Pasteur
Alain Fischer
Alain Fischer Collège de France

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