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Biology and Biochemistry

D-Index
48
Citations
26093
World Ranking
18172
National Ranking
7426

Overview

Hartmut Land is affiliated with the University of Rochester Medical Center in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine.

Their main areas of study include Molecular Biology, Pathology and Forensic Medicine, Computational Theory and Mathematics, Surgery, and Oncology. The focus of their work highlights topics such as Gene Regulatory Network Analysis, Bioinformatics and Genomic Networks, Computational Drug Discovery Methods, Cholangiocarcinoma and Gallbladder Cancer Studies, Chromatin Remodeling and Cancer, Cancer Mechanisms and Therapy, and Genetic Factors in Colorectal Cancer.

Hartmut Land has published research in various scientific venues. The most frequent publication journals include:

  • Cell Reports
  • Gastroenterology
  • STAR Protocols
  • bioRxiv (Cold Spring Harbor Laboratory)

Some of their recent papers are:

  • Exon-Skipping-Based Subtyping of Colorectal Cancers, 2024, Gastroenterology
  • Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma, 2022, Cell Reports
  • Protocol to use TopNet for gene regulatory network modeling using gene expression data from perturbation experiments, 2022, STAR Protocols
  • Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes, 2021, Cell Reports
  • Gene network modeling via TopNet reveals robust epistatic interactions between functionally diverse tumor critical mediator genes, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their research include Aslihan Ambeskovic, Matthew N. McCall, Helene R. McMurray, Harry A. Stern, and Laurel Newman. The collaboration patterns indicate recurring joint efforts, especially with Ambeskovic and McCall.

Best Publications

  • Induction of apoptosis in fibroblasts by c-myc protein

    Gerard I. Evan;Andrew H. Wyllie;Christopher S. Gilbert;Trevor D. Littlewood

  • Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

    Hartmut Land;Luis F. Parada;Robert A. Weinberg

  • Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

    Jay P. Morgenstern;Hartmut Land

  • Cellular Oncogenes and Multistep Carcinogenesis

    Hartmut Land;Luis F. Parada;Robert A. Weinberg

  • Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

    Luis F. Parada;Hartmut Land;Robert A. Weinberg;David Wolf

  • Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor.

    Hartmut Land;Günther Schütz;Hartwig Schmale;Dietmar Richter

  • Oncogenic activity of the c-Myc protein requires dimerization with Max

    Bruno Amati;Mary W. Brooks;Naomi Levy;Trevor D. Littlewood

  • Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

    Oliver Bogler;Damian Wren;Susan C. Barnett;Hartmut Land

  • High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

    A Sewing;B Wiseman;A C Lloyd;H Land

  • Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

    Bruno Amati;Stephen Dalton;Mary W. Brooks;Trevor D. Littlewood

  • The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

    B Amati;T D Littlewood;G I Evan;H Land

  • Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death.

    Bruno Amati;Hartmut Land

  • Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

    Timothy C. Thompson;Jennifer Southgate;Hartmut Land

  • A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

    Jay P. Morgenstern;Hartmut Land

  • 5′-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency

    Hartmut Land;Manuel Grez;Hansjörg Hauser;Werner Lindenmaier

  • Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1

    Ignacio Perez‐Roger;Soo‐Hyun Kim;Beatrice Griffiths;Andreas Sewing

  • Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.

    H Land;A C Chen;J P Morgenstern;L F Parada

  • Negative autoregulation of c-myc transcription.

    L. J. Z. Penn;M. W. Brooks;E. M. Laufer;H. Land

  • Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes.

    Ignacio Pérez-Roger;David Lc Solomon;Andreas Sewing;Hartmut Land

  • Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation.

    A. J. Ridley;H. F. Paterson;M. Noble;H. Land

Frequent Co-Authors

Günther Schütz
Günther Schütz German Cancer Research Center
Luis F. Parada
Luis F. Parada Memorial Sloan Kettering Cancer Center
Gerard I. Evan
Gerard I. Evan The Francis Crick Institute
Bruno Amati
Bruno Amati European Institute of Oncology
Craig T. Jordan
Craig T. Jordan University of Colorado Anschutz Medical Campus
Mark Noble
Mark Noble University of Rochester
Linda Z. Penn
Linda Z. Penn University of Toronto
Albrecht E. Sippel
Albrecht E. Sippel University of Freiburg
David E. Root
David E. Root Broad Institute

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