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Charles L. Sentman

Charles L. Sentman

D-Index & Metrics

Microbiology

D-Index
58
Citations
11917
World Ranking
3429
National Ranking
1353

Overview

Charles L. Sentman is affiliated with Dartmouth College in the United States and has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research focuses primarily on CAR-T cell therapy, immune cell function and interaction, as well as related areas such as amyotrophic lateral sclerosis research and biomedical engineering.

The scientist's work covers various aspects of immunology, oncology, neurology, molecular biology, and biomedical engineering. Key research topics include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Amyotrophic Lateral Sclerosis Research
  • Nanowire Synthesis and Applications
  • T-cell and B-cell Immunology
  • Viral Infectious Diseases and Gene Expression in Insects
  • Immunotherapy and Immune Responses

Sentman has co-authored multiple publications with frequent collaborators such as W. James Cook, Yina H. Huang, David J. Graber, Rachel A. Brog, and Marie-Louise Sentman.

Their papers have appeared in a variety of specialized journals. Frequent venues of publication include:

  • Cytotherapy
  • The Journal of Immunology
  • Clinical Cancer Research
  • Cancer Immunology Research
  • Cancer Immunology Immunotherapy

Some of the recent publications by Sentman are:

  • Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma, 2022, Clinical Cancer Research
  • Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors, 2022, Cancer Immunology Research
  • Toxicity Induced by a Bispecific T Cell-Redirecting Protein Is Mediated by Both T Cells and Myeloid Cells in Immunocompetent Mice, 2020, The Journal of Immunology
  • Human CD4+CD25+ T cells expressing a chimeric antigen receptor against aberrant superoxide dismutase 1 trigger antigen-specific immunomodulation, 2023, Cytotherapy
  • Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30, 2021, Cancer Immunology Immunotherapy

The research undertaken by Charles L. Sentman is characterized by a strong emphasis on immune system modulation, particularly through engineered immune cells such as CAR-T cells. The work spans from fundamental immunology to translational applications addressing cancer and neurological diseases.

Best Publications

  • bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.

    Charles L. Sentman;John R. Shutter;David Hockenbery;Osami Kanagawa

  • Innate and adaptive immunity in female genital tract: cellular responses and interactions.

    Charles R. Wira;John V. Fahey;Charles L. Sentman;Patricia A. Pioli

  • Bispecific T-cell engagers for cancer immunotherapy

    Amelia M Huehls;Tiffany A Coupet;Charles L Sentman

  • Biopolymer implants enhance the efficacy of adoptive T-cell therapy

    Sirkka B Stephan;Alexandria M Taber;Ilona Jileaeva;Ericka P Pegues

  • Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma

    Susanne H. Baumeister;Joana Murad;Lillian Werner;Heather Daley

  • NKG2D ligands as therapeutic targets

    Paul Spear;Ming-Ru Wu;Marie-Louise Sentman;Charles L. Sentman

  • NKG2D-Based CAR T Cells and Radiotherapy Exert Synergistic Efficacy in Glioblastoma.

    Tobias Weiss;Michael Weller;Matthias Guckenberger;Charles L Sentman

  • Vascular Endothelial Growth Factor C Facilitates Immune Tolerance and Endovascular Activity of Human Uterine NK Cells at the Maternal-Fetal Interface

    Satyan S. Kalkunte;Teddy F. Mselle;Wendy E. Norris;Charles R. Wira

  • Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity

    Juan R. Cubillos-Ruiz;Xavier Engle;Uciane K. Scarlett;Diana Martinez

  • Host MHC class I gene control of NK-cell specificity in the mouse.

    Petter Hoglund;Jonas Sundback;Mats Y. Olsson-Alheim;Maria Johansson

  • Recruitment of Uterine NK Cells: Induction of CXC Chemokine Ligands 10 and 11 in Human Endometrium by Estradiol and Progesterone

    Charles L. Sentman;Sarah K. Meadows;Charles R. Wira;Mikael Eriksson

  • Identification of a subset of murine natural killer cells that mediates rejection of Hh-1d but not Hh-1b bone marrow grafts.

    C L Sentman;J Hackett;V Kumar;M Bennett

  • Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-β

    Mikael Eriksson;Sarah K. Meadows;Charles R. Wira;Charles L. Sentman

  • Chimeric NK-receptor–bearing T cells mediate antitumor immunotherapy

    Tong Zhang;Bethany A. Lemoi;Charles L. Sentman

  • Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.

    Mats Y. Olsson;Klas Karre;Charles L. Sentman

  • T cell receptor-deficient t cell compositions

    Charles L. Sentman

  • Generation of antitumor responses by genetic modification of primary human T cells with a chimeric NKG2D receptor

    Tong Zhang;Amorette Barber;Charles L. Sentman

  • Depletion of Dendritic Cells Delays Ovarian Cancer Progression by Boosting Antitumor Immunity

    Eduardo Huarte;Juan R. Cubillos-Ruiz;Yolanda C. Nesbeth;Uciane K. Scarlett

  • An NKp30-Based Chimeric Antigen Receptor Promotes T Cell Effector Functions and Antitumor Efficacy In Vivo

    Tong Zhang;Ming-Ru Wu;Charles L. Sentman

  • NKG2D CARs as cell therapy for cancer.

    Charles L. Sentman;Kenneth R. Meehan

  • Acquisition of External Major Histocompatibility Complex Class I Molecules by Natural Killer Cells Expressing Inhibitory Ly49 Receptors

    Anna Sjöström;Mikael Eriksson;Cristina Cerboni;Maria H. Johansson

  • Evolution of non-cytotoxic uterine natural killer cells.

    Satyan Kalkunte;Clinton O. Chichester;Francesca Gotsch;Charles L. Sentman

  • Chimeric Antigen Receptor T Cells Shape Myeloid Cell Function within the Tumor Microenvironment through IFN-γ and GM-CSF

    Paul Spear;Amorette Barber;Agnieszka Rynda-Apple;Charles L. Sentman

  • Chimeric NKG2D Expressing T Cells Eliminate Immunosuppression and Activate Immunity within the Ovarian Tumor Microenvironment

    Amorette Barber;Agnieszka Rynda;Charles L. Sentman

Frequent Co-Authors

Charles R. Wira
Charles R. Wira Dartmouth College
Marc S. Ernstoff
Marc S. Ernstoff Roswell Park Cancer Institute
Jose R. Conejo-Garcia
Jose R. Conejo-Garcia Duke University
Michael Weller
Michael Weller University of Zurich
Margaret E. Ackerman
Margaret E. Ackerman Dartmouth College
Klas Kärre
Klas Kärre Karolinska Institute
Richard Stone
Richard Stone Harvard University
Mikael Eriksson
Mikael Eriksson Karolinska Institute
Robert J. Soiffer
Robert J. Soiffer Harvard University
Jerome Ritz
Jerome Ritz Harvard University

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