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Immunology

D-Index
51
Citations
19647
World Ranking
4103
National Ranking
1870

Overview

Arash Grakoui is affiliated with Emory University School of Medicine in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a particular focus on immunology, hepatology, infectious diseases, epidemiology, and molecular biology.

The scientist's work covers several main topics, including:

  • Hepatitis C virus research
  • SARS-CoV-2 and COVID-19 research
  • Immune cell function and interaction
  • COVID-19 clinical research studies
  • T-cell and B-cell immunology
  • Liver disease diagnosis and treatment
  • Monoclonal and polyclonal antibodies research

Frequent publication venues for Arash Grakoui include bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, Hepatology, Nature Communications, and Journal of Clinical Investigation.

Selected recent papers authored or co-authored by the scientist include:

  • "Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders," 2020, Gastroenterology
  • "Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures," 2020, Journal of Virology
  • "mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant," 2022, Cell Reports Medicine
  • "Structural insights into hepatitis C virus receptor binding and entry," 2021, Nature
  • "Immune system control of hepatitis C virus infection," 2020, Current Opinion in Virology

Collaborations are a significant component of Grakoui's research, with frequent co-authors including Mehul S. Suthar, Eduardo Salinas, Abigail Vanderheiden, Fengzhi Jin, and Elizabeth J. Elrod.

Best Publications

  • The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

    Arash Grakoui;Shannon K. Bromley;Cenk Sumen;Mark M. Davis

  • Expression and identification of hepatitis C virus polyprotein cleavage products.

    Arash Grakoui;C. Wychowski;C. Lin;S. M. Feinstone

  • HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

    Arash Grakoui;Naglaa H Shoukry;David John Woollard;Jin-Hwan Han

  • Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites.

    A Grakoui;D W McCourt;C Wychowski;S M Feinstone

  • Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics

    Tobias Marcello;Arash Grakoui;Giovanna Barba-Spaeth;Erica S. Machlin

  • Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

    Naglaa H. Shoukry;Arash Grakoui;Michael Houghton;David Y. Chien

  • A second hepatitis C virus-encoded proteinase.

    Arash Grakoui;David W. McCourt;Czeslaw Wychowski;Stephen M. Feinstone

  • Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

    Henry Radziewicz;Chris C. Ibegbu;Marina L. Fernandez;Kimberly A. Workowski

  • Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

    Glenn Randall;Arash Grakoui;Charles M. Rice

  • Glucagon‐like peptide‐1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway

    Nitika Arora Gupta;Jamie Mells;Richard M. Dunham;Arash Grakoui

  • Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders

    Daniel M. Chopyk;Arash Grakoui;Arash Grakoui

  • HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.

    M J Koziel;D Dudley;N Afdhal;A Grakoui

  • Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

    Kristi L. Berger;Jacob D. Cooper;Nicholas S. Heaton;Rosa Yoon

  • Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics.

    Chao Lin;B. M. Pragai;A. Grakoui;Jian Xu

  • Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites.

    T J Chambers;A Grakoui;C M Rice

  • Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules.

    M Battegay;J Fikes;A M Di Bisceglie;P A Wentworth

  • Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

    Unknown

  • Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures.

    Abigail Vanderheiden;Philipp Ralfs;Philipp Ralfs;Tatiana Chirkova;Amit A. Upadhyay;Amit A. Upadhyay

  • Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2

    Abdul Ghafoor Khan;Jillian Whidby;Matthew T. Miller;Hannah Scarborough

  • mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant

    Unknown

  • Cas9-mediated targeting of viral RNA in eukaryotic cells

    Aryn A. Price;Timothy R. Sampson;Hannah K. Ratner;Arash Grakoui

  • Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

    Michael J. Fuller;Benoit Callendret;Baogong Zhu;Gordon J. Freeman

Frequent Co-Authors

Christopher M. Walker
Christopher M. Walker The Ohio State University
Mehul S. Suthar
Mehul S. Suthar Emory University
Steven E. Bosinger
Steven E. Bosinger Emory University
Charles M. Rice
Charles M. Rice Rockefeller University
Vineet D. Menachery
Vineet D. Menachery The University of Texas Medical Branch at Galveston
Cheng Zhu
Cheng Zhu Georgia Institute of Technology
Rafi Ahmed
Rafi Ahmed Emory University
Gordon J. Freeman
Gordon J. Freeman Harvard University
Pei-Yong Shi
Pei-Yong Shi GlaxoSmithKline (United Kingdom)
François-Loïc Cosset
François-Loïc Cosset Claude Bernard University Lyon 1

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