World's Best Scientists 2026 revealed!

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Immunology

D-Index
84
Citations
25194
World Ranking
1379
National Ranking
708

Medicine

D-Index
84
Citations
25221
World Ranking
15128
National Ranking
7640

Overview

Alan L. Rothman is affiliated with the University of Rhode Island in the United States and works primarily in the field of medicine. Their research focuses largely on public health, infectious diseases, modeling and simulation, immunology, and virology. The main topics addressed in their work include mosquito-borne diseases and control, viral infections and vectors, COVID-19 epidemiological studies, malaria research and control, viral infections and outbreaks research, HIV research and treatment, and T-cell and B-cell immunology.

Rothman has contributed extensively to scientific literature, with notable recurring publication venues including bioRxiv (Cold Spring Harbor Laboratory), PLoS Neglected Tropical Diseases, Proceedings of the National Academy of Sciences, The Journal of Infectious Diseases, and PLoS Computational Biology. Their involvement in these venues spans a range of studies related to infectious diseases and epidemiology.

Their recent papers illustrate diverse research interests and collaborations, featuring the following publications:

  • Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection, 2021, Nature Medicine
  • Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections, 2021, PLoS Pathogens
  • Assessing the role of multiple mechanisms increasing the age of dengue cases in Thailand, 2022, Proceedings of the National Academy of Sciences
  • Transcriptional and clonal characterization of B cell plasmablast diversity following primary and secondary natural DENV infection, 2020, EBioMedicine
  • Disease-driven reduction in human mobility influences human-mosquito contacts and dengue transmission dynamics, 2021, PLoS Computational Biology

Frequent co-authors working alongside Rothman include Stefan Fernandez, Anon Srikiatkhachorn, Stephen J. Thomas, Sopon Iamsirithaworn, and Henrik Salje. These collaborations reflect interdisciplinary efforts and a broad range of expertise in infectious disease research.

Rothman's body of work integrates epidemiological and immunological approaches to understanding viral diseases, with a focus on vector-borne illnesses such as dengue and malaria, as well as broader viral infection patterns and immune system responses. Their modeling and simulation research supports insights into disease transmission dynamics and outbreak investigations.

Best Publications

  • Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity

    David W. Vaughn;Sharone Green;Siripen Kalayanarooj;Bruce L. Innis

  • High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever

    Daniel H. Libraty;Paul R. Young;Darren Pickering;Timothy P. Endy

  • Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms

    Alan L. Rothman

  • Early Clinical and Laboratory Indicators of Acute Dengue Illness

    S. Kalayanarooj;D. W. Vaughn;S. Nimmannitya;S. Green

  • Differing Influences of Virus Burden and Immune Activation on Disease Severity in Secondary Dengue-3 Virus Infections

    Daniel H. Libraty;Timothy P. Endy;Huo-Shu H. Houng;Sharone Green

  • Epidemiology of Inapparent and Symptomatic Acute Dengue Virus Infection: A Prospective Study of Primary School Children in Kamphaeng Phet, Thailand

    Timothy P. Endy;Supamit Chunsuttiwat;Ananda Nisalak;Daniel H. Libraty

  • Dengue in the early febrile phase : Viremia and antibody responses

    David W. Vaughn;Sharone Green;Siripen Kalayanarooj;Bruce L. Innis

  • Immunopathogenesis of Dengue hemorrhagic fever.

    Alan L. Rothman;Francis A. Ennis

  • Dengue: defining protective versus pathologic immunity

    Alan L. Rothman

  • Immunopathological mechanisms in dengue and dengue hemorrhagic fever.

    Sharone Green;Alan Rothman

  • Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity

    Sharone Green;David W. Vaughn;Siripen Kalayanarooj;Suchitra Nimmannitya

  • Iron and chronic viral hepatitis

    H L Bonkovsky;B F Banner;A L Rothman

  • Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand.

    Timothy P. Endy;Ananda Nisalak;Supamit Chunsuttitwat;David W. Vaughn

  • Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006.

    Jessica R. Fried;Robert V. Gibbons;Siripen Kalayanarooj;Stephen J. Thomas

  • Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages

    Mammen P Mammen;Chusak Pimgate;Constantianus J. M Koenraadt;Alan L Rothman

  • HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais

    H. A. F. Stephens;H. A. F. Stephens;R. Klaythong;M. Sirikong;D. W. Vaughn

  • Understanding the contribution of cellular immunity to dengue disease pathogenesis

    Anuja Mathew;Alan L. Rothman

  • Reconstruction of antibody dynamics and infection histories to evaluate dengue risk.

    Henrik Salje;Derek A.T. Cummings;Derek A.T. Cummings;Isabel Rodriguez-Barraquer;Leah C. Katzelnick

  • High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome.

    Masuko Mori;Alan L. Rothman;Ichiro Kurane;James M. Montoya

  • Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study.

    Anon Srikiatkhachorn;Anchalee Krautrachue;Warangkana Ratanaprakarn;Lawan Wongtapradit

  • Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever.

    Sharone Green;Sathit Pichyangkul;David W. Vaughn;Siripen Kalayanarooj

Frequent Co-Authors

Francis A. Ennis
Francis A. Ennis University of Massachusetts Chan Medical School
Sharone Green
Sharone Green University of Massachusetts Chan Medical School
Siripen Kalayanarooj
Siripen Kalayanarooj Queen Sirikit National Institute of Child Health
Ananda Nisalak
Ananda Nisalak United States Department of the Army
Timothy P. Endy
Timothy P. Endy SUNY Upstate Medical University
Daniel H. Libraty
Daniel H. Libraty University of Massachusetts Chan Medical School
Richard G. Jarman
Richard G. Jarman Walter Reed Army Institute of Research
Robert V. Gibbons
Robert V. Gibbons United States Department of the Army
David W. Vaughn
David W. Vaughn Bill & Melinda Gates Foundation
Thomas W. Scott
Thomas W. Scott University of California, Davis

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