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Microbiology

D-Index
80
Citations
40575
World Ranking
1132
National Ranking
5

Overview

David C. Lye is affiliated with Tan Tock Seng Hospital in Singapore. Their research primarily focuses on the field of Medicine, with a significant concentration in Infectious Diseases. Other subfields include Neurology, Epidemiology, Modeling and Simulation, and Public Health, Environmental and Occupational Health.

The scientist has contributed extensively to topics related to SARS-CoV-2 and COVID-19 research. Their work covers the following main topics:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Long-Term Effects of COVID-19
  • SARS-CoV-2 detection and testing
  • COVID-19 epidemiological studies
  • Vaccine Coverage and Hesitancy
  • Antibiotic Use and Resistance

Recent significant publications by David C. Lye include:

  • Remdesivir for the Treatment of Covid-19 - Final Report, 2020, New England Journal of Medicine
  • Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore, 2020, JAMA
  • Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19, 2020, New England Journal of Medicine
  • Remdesivir for 5 or 10 Days in Patients with Severe Covid-19, 2020, New England Journal of Medicine
  • Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail, 2020, Science

Frequent collaborators include:

  • Barnaby Edward Young
  • Yee-Sin Leo
  • Laurent Rénia
  • Lisa F. P. Ng
  • Siew-Wai Fong

Their research has been disseminated through several publication venues with multiple contributions in these journals and platforms:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Infectious Diseases
  • Open Forum Infectious Diseases
  • SSRN Electronic Journal
  • Clinical Microbiology and Infection

Best Publications

  • Remdesivir for the Treatment of Covid-19 - Final Report.

    John H. Beigel;Kay M. Tomashek;Lori E. Dodd;Aneesh K. Mehta

  • Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.

    Barnaby Edward Young;Sean Wei Xiang Ong;Shirin Kalimuddin;Shirin Kalimuddin;Jenny G. Low;Jenny G. Low

  • Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.

    Andre C Kalil;Thomas F Patterson;Aneesh K Mehta;Kay M Tomashek

  • Remdesivir for 5 or 10 Days in Patients with Severe Covid-19.

    Jason D. Goldman;David C.B. Lye;David S. Hui;Kristen M. Marks

  • Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.

    Johanna Hansen;Alina Baum;Kristen E. Pascal;Vincenzo Russo

  • A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction.

    Chee Wah Tan;Wan Ni Chia;Xijian Qin;Pei Liu

  • Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients.

    Po Ying Chia;Po Ying Chia;Kristen Kelli Coleman;Yian Kim Tan;Sean Wei Xiang Ong

  • Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance A Randomized Clinical Trial

    Patrick N. A. Harris;Patrick N. A. Harris;Patrick N. A. Harris;Paul A. Tambyah;David C. Lye;David C. Lye;David C. Lye;Yin Mo

  • Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures.

    Rachael Pung;Calvin J. Chiew;Barnaby E. Young;Sarah Chin

  • Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.

    Anthony T. Tan;Martin Linster;Chee Wah Tan;Nina Le Bert

  • Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey.

    Ann Versporten;Peter Zarb;Isabelle Caniaux;Marie Françoise Gros

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective cohort study comparing B.1.1.7 (Alpha), B.1.315 (Beta), and B.1.617.2 (Delta).

    Sean Wei Xiang Ong;Calvin J Chiew;Li Wei Ang;Tze-Minn Mak

  • Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients.

    Chek Meng Poh;Guillaume Carissimo;Bei Wang;Siti Naqiah Amrun

  • Assessing Viral Shedding and Infectivity of Tears in Coronavirus Disease 2019 (COVID-19) Patients.

    Ivan Yu Jun Seah;Danielle E. Anderson;Adrian Eng Zheng Kang;Linfa Wang

  • Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study.

    Barnaby E Young;Barnaby E Young;Siew-Wai Fong;Siew-Wai Fong;Yi-Hao Chan;Tze-Minn Mak

  • Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study

    Po Ying Chia;Po Ying Chia;Sean Wei Xiang Ong;Calvin J. Chiew;Li Wei Ang

  • Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore - January 2-February 29, 2020.

    Yixiang Ng;Zongbin Li;Yi Xian Chua;Wei Liang Chaw

  • Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.

    Wan Ni Chia;Feng Zhu;Sean Wei Xiang Ong;Barnaby Edward Young;Barnaby Edward Young

  • Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.

    Nina Le Bert;Hannah E. Clapham;Anthony T. Tan;Wan Ni Chia

Frequent Co-Authors

Yee Sin Leo
Yee Sin Leo Nanyang Technological University
Barnaby Young
Barnaby Young National Centre for Infectious Diseases
Vernon J. Lee
Vernon J. Lee Ministry of Health
Lisa F. P. Ng
Lisa F. P. Ng Agency for Science, Technology and Research
Laurent Rénia
Laurent Rénia Nanyang Technological University
Paul A. Tambyah
Paul A. Tambyah National University of Singapore
Raymond T. P. Lin
Raymond T. P. Lin National University of Singapore
Lin-Fa Wang
Lin-Fa Wang Duke NUS Graduate Medical School
Antonio Bertoletti
Antonio Bertoletti Duke NUS Graduate Medical School
Vincent H. Tam
Vincent H. Tam University of Houston

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