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Biology and Biochemistry

D-Index
56
Citations
13779
World Ranking
14272
National Ranking
158

Overview

Thomas Litman is affiliated with the University of Copenhagen in Denmark. Their research primarily lies within the field of Medicine, with a significant focus on Dermatology, Immunology, Molecular Biology, Oncology, and Epidemiology. The scientist's portfolio includes work across several subfields and topics related to dermatological and immunological conditions.

The main topics of their research include:

  • Dermatology and Skin Diseases
  • Cutaneous lymphoproliferative disorders research
  • Fungal Infections and Studies
  • T-cell and Retrovirus Studies
  • Allergic Rhinitis and Sensitization
  • IL-33, ST2, and ILC Pathways
  • Lymphoma Diagnosis and Treatment

Thomas Litman has published extensively, with notable recent papers including:

  • "Human pathways in animal models: possibilities and limitations," 2021, Nucleic Acids Research
  • "Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma," 2022, Blood
  • "MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas," 2020, Cancers
  • "Inhibition of succinate dehydrogenase activity impairs human T cell activation and function," 2021, Scientific Reports
  • "HSP90 inhibitor RGRN-305 for oral treatment of plaque-type psoriasis: efficacy, safety and biomarker results in an open-label proof-of-concept study," 2021, British Journal of Dermatology

The scientist frequently collaborates with several researchers, including:

  • Niels Ødum, with 17 collaborations
  • Lise Mette Rahbek Gjerdrum, with 14 collaborations
  • Lars Iversen, with 14 collaborations
  • Anders Woetmann, with 14 collaborations
  • Lise M. Lindahl, with 13 collaborations

Thomas Litman's research has appeared predominantly in journals such as the Journal of Investigative Dermatology, where they have 13 publications, followed by the International Journal of Molecular Sciences and Acta Dermato Venereologica, each with five publications. Other recurring venues include the Journal of Allergy and Clinical Immunology and bioRxiv (Cold Spring Harbor Laboratory), each hosting three of their papers.

Best Publications

  • Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

    Keisuke Miyake;Lyn Mickley;Thomas Litman;Zhirong Zhan

  • From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

    T. Litman;T. E. Druley;W. D. Stein;S. E. Bates

  • The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

    Thomas Litman;Mariafiorella Brangi;Eric Hudson;Patricia Fetsch

  • Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells

    Yasumasa Honjo;Christine A. Hrycyna;Qing-Wu Yan;Wilma Y. Medina-Pérez

  • Overexpression of the ATP-binding Cassette Half-Transporter, ABCG2 (MXR/BCRP/ABCP1), in Flavopiridol-resistant Human Breast Cancer Cells

    Robert W. Robey;Wilma Y. Medina-Pérez;Kenryu Nishiyama;Tyler Lahusen

  • Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.

    Csilla Özvegy;Thomas Litman;Gergely Szakács;Zoltán Nagy

  • The effect of short-chain fatty acids on human monocyte-derived dendritic cells

    Claudia Nastasi;Marco Candela;Charlotte Menné Bonefeld;Carsten Geisler

  • Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR

    Michiel de Bruin;Keisuke Miyake;Thomas Litman;Robert Robey

  • Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.

    Mariafiorella Brangi;Thomas Litman;Marco Ciotti;Kenryu Nishiyama

  • Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer

    E S Martens-Uzunova;S E Jalava;N F Dits;G J L H van Leenders

  • A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).

    Robert W Robey;Yasumasa Honjo;Anne van de Laar;Keisuke Miyake

  • Diagnostic microrna profiling in cutaneous t-cell lymphoma (ctcl)

    Ulrik Ralfkiaer;Peter Hagedorn;Charlotte Busch Ahler;Carsten Geisler

  • Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues

    Patricia A. Fetsch;Andrea Abati;Thomas Litman;Kuniaki Morisaki

  • The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane.

    Emmanuelle Rocchi;Alexey Khodjakov;Alexey Khodjakov;Erin L. Volk;Erin L. Volk;Chih-Hsin Yang

  • MicroRNAs and potential target interactions in psoriasis

    John R. Zibert;Marianne B. Løvendorf;Thomas Litman;Jørgen Olsen

  • Measurement of Cell Volume Changes by Fluorescence Self-Quenching

    Steffen Hamann;Jens Folke Kiilgaard;Thomas Litman;Francisco J. Alvarez-Leefmans

  • Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity.

    Thomas Litman;Thomas Zeuthen;Torben Skovsgaard;Wilfred D Stein

  • Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.

    Claus Juul Loland;Lene Norregaard;Thomas Litman;Ulrik Gether

  • Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity

    Thomas Litman;Thomas Zeuthen;Torben Skovsgaard;Wilfred D. Stein

  • Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line.

    Kenneth K. W. To;Zhirong Zhan;Thomas Litman;Susan E. Bates

Frequent Co-Authors

Niels Ødum
Niels Ødum University of Copenhagen
Susan E. Bates
Susan E. Bates Columbia University
Wilfred D. Stein
Wilfred D. Stein Hebrew University of Jerusalem
Anders Woetmann
Anders Woetmann University of Copenhagen
Lars Iversen
Lars Iversen Aarhus University Hospital
Carsten Geisler
Carsten Geisler University of Copenhagen
Tito Fojo
Tito Fojo Columbia University
Henrik J. Ditzel
Henrik J. Ditzel University of Southern Denmark
Thomas Zeuthen
Thomas Zeuthen University of Copenhagen
Emma Guttman-Yassky
Emma Guttman-Yassky Icahn School of Medicine at Mount Sinai

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