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Ryan M. O'Connell

Ryan M. O'Connell

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
23409
World Ranking
14746
National Ranking
6163

Overview

Ryan M. O'Connell is affiliated with the University of Utah in the United States. Their research spans several key areas within the life sciences, particularly focusing on biochemistry, genetics, and molecular biology, medicine, and immunology and microbiology. The body of work reflects a significant contribution to molecular biology and immunology, with notable attention to cancer research and neurology as subfields.

Their recent publications cover a range of topics in high-impact journals. These include:

  • Adaptive immunity induces mutualism between commensal eukaryotes, 2021, Nature
  • CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments, 2020, BMC Bioinformatics
  • Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system, 2020, Glia
  • A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages, 2021, Nature Communications
  • Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development, 2020, Cell Reports

Their research covers multiple specialized topics, which include:

  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • Immune Cell Function and Interaction
  • Immune cells in cancer
  • Extracellular vesicles in disease
  • Gut microbiota and health
  • Cancer-related molecular mechanisms research

Collaborations have played an important role in their scientific output, with frequent co-authors being:

  • Kaylyn M. Bauer
  • H. Atakan Ekiz
  • June L. Round
  • William W. Tang
  • Warren P. Voth

The venues in which O'Connell has published frequently include:

  • The Journal of Immunology
  • Cell Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Frontiers in Immunology

Overall, their work is characterized by a multidisciplinary approach, often intersecting immunology and molecular biology with applications in cancer and infectious disease research. The publication record demonstrates activity in both experimental and computational biology, including the development of analytical tools for single-cell RNA sequencing data annotation. This profile illustrates an extensive engagement with immune cell regulation, host-pathogen interactions, and metabolic regulation within immune contexts.

Best Publications

  • MicroRNA-155 is induced during the macrophage inflammatory response

    Ryan M. O'Connell;Konstantin D. Taganov;Mark P. Boldin;Genhong Cheng

  • Physiological and pathological roles for microRNAs in the immune system

    Ryan M. O'Connell;Dinesh S. Rao;Dinesh S. Rao;Aadel A. Chaudhuri;David Baltimore

  • MicroRNAs: new regulators of immune cell development and function.

    David Baltimore;Mark P Boldin;Ryan M O'Connell;Dinesh S Rao;Dinesh S Rao

  • IRF3 mediates a TLR3/TLR4-specific antiviral gene program

    Sean E. Doyle;Sagar A. Vaidya;Ryan O'Connell;Hajir Dadgostar

  • MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development

    Ryan M. O'Connell;Daniel A. Kahn;Daniel A. Kahn;William S. J. Gibson;June L. Round

  • Inositol phosphatase SHIP1 is a primary target of miR-155.

    Ryan M. O'Connell;Aadel A. Chaudhuri;Dinesh S. Rao;Dinesh S. Rao;David Baltimore

  • microRNA Regulation of Inflammatory Responses

    Ryan M. O'Connell;Dinesh S. Rao;Dinesh S. Rao;David Baltimore

  • Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder.

    Ryan M. O'Connell;Dinesh S. Rao;Aadel A. Chaudhuri;Mark P. Boldin

  • Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

    Margaret Alexander;Ruozhen Hu;Marah C. Runtsch;Dominique A. Kagele

  • LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response

    Sean B. Joseph;Michelle N. Bradley;Antonio Castrillo;Kevin W. Bruhn

  • Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection

    Ryan M. O'Connell;Supriya K. Saha;Sagar A. Vaidya;Kevin W. Bruhn

  • Toll-like Receptors Induce a Phagocytic Gene Program through p38

    Sean E. Doyle;Ryan M. O'Connell;Gustavo A. Miranda;Sagar A. Vaidya

  • Expansion of bacteriophages is linked to aggravated intestinal inflammation and colitis

    Lasha Gogokhia;Lasha Gogokhia;Kate Buhrke;Rickesha Bell;Brenden Hoffman

  • Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway

    Yuan Zhai;Xiu Da Shen;Ryan O'Connell;Feng Gao

  • NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies

    Jimmy L. Zhao;Dinesh S. Rao;Dinesh S. Rao;Mark P. Boldin;Konstantin D. Taganov

  • MyD88 Mediates Neutrophil Recruitment Initiated by IL-1R but Not TLR2 Activation in Immunity against Staphylococcus aureus

    Lloyd S. Miller;Ryan M. O'Connell;Miguel A. Gutierrez;Eric M. Pietras

  • Inflammasome-mediated production of IL-1β is required for neutrophil recruitment against Staphylococcus aureus in vivo

    Lloyd S. Miller;Eric M. Pietras;Lawrence H. Uricchio;Kathleen Hirano

  • MicroRNA-125b Potentiates Macrophage Activation

    Aadel A. Chaudhuri;Alex Yick Lun So;Nikita Sinha;William S J Gibson

  • Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

    Jimmy L. Zhao;Chao Ma;Ryan M. O’Connell;Arnav Mehta

  • MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

    Ryan M. O'Connell;Aadel A. Chaudhuri;Dinesh S. Rao;William S. J. Gibson

Frequent Co-Authors

Dinesh S. Rao
Dinesh S. Rao University of Florida
David Baltimore
David Baltimore California Institute of Technology
Genhong Cheng
Genhong Cheng University of California, Los Angeles
Thomas E. Lane
Thomas E. Lane University of California, Irvine
Robert L. Modlin
Robert L. Modlin University of California, Los Angeles
Jared Rutter
Jared Rutter University of Utah
Lloyd S. Miller
Lloyd S. Miller Johns Hopkins University
Ambrose L. Cheung
Ambrose L. Cheung Dartmouth College
Nadim J. Ajami
Nadim J. Ajami The University of Texas MD Anderson Cancer Center
James R. Heath
James R. Heath California Institute of Technology

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