World's Best Scientists 2026 revealed!
Rene De Waal Malefyt

Rene De Waal Malefyt

D-Index & Metrics

Immunology

D-Index
80
Citations
68641
World Ranking
1594
National Ranking
795

Rene De Waal Malefyt publication distribution in Immunology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Immunology in 2026. The highlighted bar marks where Rene De Waal Malefyt sits on this spectrum.

62–71 publications: 9 scientists 72–81 publications: 23 scientists 82–91 publications: 40 scientists 92–101 publications: 72 scientists 102–111 publications: 86 scientists 112–121 publications: 108 scientists 122–131 publications: 150 scientists 132–141 publications: 160 scientists 142–151 publications: 159 scientists 152–161 publications: 189 scientists 162–171 publications: 166 scientists 172–181 publications: 181 scientists 182–191 publications: 188 scientists 192–201 publications: 187 scientists 202–211 publications: 178 scientists 212–221 publications: 158 scientists 222–231 publications: 168 scientists 232–241 publications: 159 scientists 242–251 publications: 160 scientists 252–261 publications: 148 scientists 262–271 publications: 116 scientists 272–281 publications: 125 scientists 282–291 publications: 115 scientists 292–301 publications: 111 scientists 302–311 publications: 95 scientists 312–321 publications: 97 scientists 322–331 publications: 97 scientists 332–341 publications: 99 scientists 342–351 publications: 96 scientists 352–361 publications: 68 scientists 362–371 publications: 76 scientists 372–381 publications: 71 scientists 382–391 publications: 71 scientists 392–401 publications: 62 scientists 402–411 publications: 54 scientists 412–421 publications: 41 scientists 422–431 publications: 63 scientists 432–441 publications: 53 scientists 442–451 publications: 31 scientists 452–461 publications: 42 scientists 462–471 publications: 40 scientists 472–481 publications: 29 scientists 482–491 publications: 34 scientists 492–501 publications: 30 scientists 502–511 publications: 23 scientists 512–521 publications: 41 scientists 522–531 publications: 29 scientists 532–541 publications: 28 scientists 542–551 publications: 16 scientists 552–561 publications: 18 scientists 562–571 publications: 18 scientists 572–581 publications: 17 scientists 582–591 publications: 17 scientists 592–601 publications: 17 scientists 602–611 publications: 19 scientists 612–621 publications: 13 scientists 622–631 publications: 12 scientists 632–641 publications: 11 scientists 642–651 publications: 16 scientists 652–661 publications: 9 scientists 662–671 publications: 5 scientists 672–681 publications: 13 scientists 682–691 publications: 12 scientists 692–701 publications: 6 scientists 702–711 publications: 6 scientists 712–721 publications: 9 scientists 722–731 publications: 9 scientists 732–741 publications: 6 scientists 742–751 publications: 11 scientists 752–761 publications: 10 scientists 762–771 publications: 7 scientists 772–781 publications: 12 scientists 782–791 publications: 7 scientists 792–801 publications: 5 scientists 802–806 publications: 1 scientists 807+ publications: 100 scientists
62 publications 807+

This scientist: 211 publications — 38th percentile

38% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 807 publications or more.

Rene De Waal Malefyt D-index placement in Immunology in 2026

The chart shows the D-index (discipline H-index) distribution of Immunology scientists ranked by Research.com in 2026. The highlighted bar marks where Rene De Waal Malefyt sits on this spectrum.

40–41 D-Index: 28 scientists 42–43 D-Index: 91 scientists 44–45 D-Index: 157 scientists 46–47 D-Index: 192 scientists 48–49 D-Index: 175 scientists 50–51 D-Index: 188 scientists 52–53 D-Index: 177 scientists 54–55 D-Index: 155 scientists 56–57 D-Index: 194 scientists 58–59 D-Index: 201 scientists 60–61 D-Index: 197 scientists 62–63 D-Index: 201 scientists 64–65 D-Index: 173 scientists 66–67 D-Index: 167 scientists 68–69 D-Index: 172 scientists 70–71 D-Index: 199 scientists 72–73 D-Index: 184 scientists 74–75 D-Index: 133 scientists 76–77 D-Index: 162 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 121 scientists 82–83 D-Index: 125 scientists 84–85 D-Index: 121 scientists 86–87 D-Index: 102 scientists 88–89 D-Index: 96 scientists 90–91 D-Index: 75 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 74 scientists 96–97 D-Index: 66 scientists 98–99 D-Index: 68 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 60 scientists 104–105 D-Index: 54 scientists 106–107 D-Index: 36 scientists 108–109 D-Index: 23 scientists 110–111 D-Index: 52 scientists 112–113 D-Index: 41 scientists 114–115 D-Index: 34 scientists 116–117 D-Index: 25 scientists 118–119 D-Index: 28 scientists 120–121 D-Index: 11 scientists 122–123 D-Index: 20 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 19 scientists 128–129 D-Index: 20 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 17 scientists 134–135 D-Index: 14 scientists 136–137 D-Index: 15 scientists 138–139 D-Index: 9 scientists 140–141 D-Index: 11 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 9 scientists 146–147 D-Index: 7 scientists 148–149 D-Index: 7 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 5 scientists 154–155 D-Index: 8 scientists 156 D-Index: 6 scientists 157+ D-Index: 96 scientists
40 D-Index 157+

This scientist: 80 D-Index — 68th percentile

68% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 157 D-Index or more.

Overview

Rene De Waal Malefyt is affiliated with Synthekine in the United States and conducts research primarily in the fields of Immunology and Microbiology as well as Medicine. Their work spans various subfields, including Immunology, Oncology, Radiology, Nuclear Medicine and Imaging, Parasitology, and Physiology.

The main topics of their research include:

  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research
  • Asthma and respiratory diseases
  • Toxoplasma gondii Research Studies

Rene De Waal Malefyt has published in several scientific venues, frequently contributing to:

  • Cancer Research
  • Frontiers in Immunology
  • Regular and Young Investigator Award Abstracts
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology

Notable recent publications include:

  • PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection (2022, Nature Immunology)
  • An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma (2021, Science Translational Medicine)
  • Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab (2020, Molecular Cancer Therapeutics)
  • Abstract 1744: STK-012, an alpha/beta selective IL-2 mutein for the activation of the antigen-activated T cells in solid tumor (2021, Cancer Research)
  • Limited Impact of the Inhibitory Receptor TIGIT on NK and T Cell Responses during Toxoplasma gondii Infection (2021, ImmunoHorizons)

Their collaborative network includes frequent coauthors such as:

  • Sandro Vivona
  • Martin Oft
  • Deepti Rokkam
  • Patrick J. Lupardus
  • Jan Emmerich

Rene De Waal Malefyt's research addresses key areas of immunology, particularly the regulation and activation of immune cells in the context of cancer and infectious diseases. Their work on CAR-T cell therapy and cancer immunotherapy contributes to understanding therapeutic strategies and biomarkers relevant to these fields.

Best Publications

  • Interleukin-10 and the interleukin-10 receptor.

    Moore Kw;de Waal Malefyt R;Coffman Rl;O'Garra A

  • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

    R de Waal Malefyt;J Abrams;B Bennett;C G Figdor

  • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

    Birgit Oppmann;Robin Lesley;Bianca Blom;Jackie C. Timans

  • Development, cytokine profile and function of human interleukin 17-producing helper T cells

    Nicholas J Wilson;Katia Boniface;Jason R Chan;Brent S McKenzie

  • Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

    Vassili Soumelis;Pedro A Reche;Holger Kanzler;Wei Yuan

  • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.

    Norimitsu Kadowaki;Stephen Ho;Svetlana Antonenko;Rene de Waal Malefyt

  • Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

    Marie-Clotilde Rissoan;Vassili Soumelis;Norimitsu Kadowaki;Geraldine Grouard

  • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

    R de Waal Malefyt;J Haanen;H Spits;M G Roncarolo

  • IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

    Stefan Pflanz;Jackie C Timans;Jeanne Cheung;Rency Rosales

  • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

    Franck J. Barrat;Daniel J. Cua;André Boonstra;David F. Richards

  • A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

    Christi Parham;Madaline Chirica;Jacqueline Timans;Elena Vaisberg

  • Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

    J. Punnonen;G. Aversa;B. G. Cocks;A. N. J. Mckenzie

  • Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

    Frank A. W. Verreck;Tjitske de Boer;Dennis M. L. Langenberg;Marieke A. Hoeve

  • Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

    P Vieira;R de Waal-Malefyt;M N Dang;K E Johnson

  • IL-12 and IL-23: master regulators of innate and adaptive immunity.

    Claire L Langrish;Brent S McKenzie;Nicholas J Wilson;Rene de Waal Malefyt

  • IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.

    Jason R. Chan;Wendy Blumenschein;Erin Murphy;Caroline Diveu

  • WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27

    Stefan Pflanz;Linda Hibbert;Jeanine Mattson;Rency Rosales

  • Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

    Marcel B.M. Teunissen;Jan D. Bos;Cock W. Koomen;Rene de Waal Malefyt

  • TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation

    Yong Jun Liu;Vasilli Soumelis;Norihiko Watanabe;Tomoki Ito

  • Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

    A N McKenzie;J A Culpepper;R de Waal Malefyt;F Brière

  • Interleukin-10.

    Unknown

Frequent Co-Authors

Satwant K. Narula
Satwant K. Narula Weizenbaum-Institut
Terrill K. McClanahan
Terrill K. McClanahan MSD (United States)
Cox Terhorst
Cox Terhorst Beth Israel Deaconess Medical Center
Jonathan M. Spergel
Jonathan M. Spergel University of Pennsylvania
Hakon Hakonarson
Hakon Hakonarson Children's Hospital of Philadelphia
Robert A. Kastelein
Robert A. Kastelein MSD (United States)
David Artis
David Artis Cornell University
Atul K. Bhan
Atul K. Bhan Harvard University
Patrick M.A. Sleiman
Patrick M.A. Sleiman Children's Hospital of Philadelphia
Roland W. Herzog
Roland W. Herzog Indiana University

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