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Rene De Waal Malefyt

Rene De Waal Malefyt

D-Index & Metrics

Immunology

D-Index
80
Citations
68641
World Ranking
1594
National Ranking
795

Overview

Rene De Waal Malefyt is affiliated with Synthekine in the United States and conducts research primarily in the fields of Immunology and Microbiology as well as Medicine. Their work spans various subfields, including Immunology, Oncology, Radiology, Nuclear Medicine and Imaging, Parasitology, and Physiology.

The main topics of their research include:

  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research
  • Asthma and respiratory diseases
  • Toxoplasma gondii Research Studies

Rene De Waal Malefyt has published in several scientific venues, frequently contributing to:

  • Cancer Research
  • Frontiers in Immunology
  • Regular and Young Investigator Award Abstracts
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology

Notable recent publications include:

  • PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection (2022, Nature Immunology)
  • An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma (2021, Science Translational Medicine)
  • Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab (2020, Molecular Cancer Therapeutics)
  • Abstract 1744: STK-012, an alpha/beta selective IL-2 mutein for the activation of the antigen-activated T cells in solid tumor (2021, Cancer Research)
  • Limited Impact of the Inhibitory Receptor TIGIT on NK and T Cell Responses during Toxoplasma gondii Infection (2021, ImmunoHorizons)

Their collaborative network includes frequent coauthors such as:

  • Sandro Vivona
  • Martin Oft
  • Deepti Rokkam
  • Patrick J. Lupardus
  • Jan Emmerich

Rene De Waal Malefyt's research addresses key areas of immunology, particularly the regulation and activation of immune cells in the context of cancer and infectious diseases. Their work on CAR-T cell therapy and cancer immunotherapy contributes to understanding therapeutic strategies and biomarkers relevant to these fields.

Best Publications

  • Interleukin-10 and the interleukin-10 receptor.

    Moore Kw;de Waal Malefyt R;Coffman Rl;O'Garra A

  • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

    R de Waal Malefyt;J Abrams;B Bennett;C G Figdor

  • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

    Birgit Oppmann;Robin Lesley;Bianca Blom;Jackie C. Timans

  • Development, cytokine profile and function of human interleukin 17-producing helper T cells

    Nicholas J Wilson;Katia Boniface;Jason R Chan;Brent S McKenzie

  • Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

    Vassili Soumelis;Pedro A Reche;Holger Kanzler;Wei Yuan

  • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.

    Norimitsu Kadowaki;Stephen Ho;Svetlana Antonenko;Rene de Waal Malefyt

  • Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

    Marie-Clotilde Rissoan;Vassili Soumelis;Norimitsu Kadowaki;Geraldine Grouard

  • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

    R de Waal Malefyt;J Haanen;H Spits;M G Roncarolo

  • IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

    Stefan Pflanz;Jackie C Timans;Jeanne Cheung;Rency Rosales

  • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

    Franck J. Barrat;Daniel J. Cua;André Boonstra;David F. Richards

  • A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

    Christi Parham;Madaline Chirica;Jacqueline Timans;Elena Vaisberg

  • Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

    J. Punnonen;G. Aversa;B. G. Cocks;A. N. J. Mckenzie

  • Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

    Frank A. W. Verreck;Tjitske de Boer;Dennis M. L. Langenberg;Marieke A. Hoeve

  • Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

    P Vieira;R de Waal-Malefyt;M N Dang;K E Johnson

  • IL-12 and IL-23: master regulators of innate and adaptive immunity.

    Claire L Langrish;Brent S McKenzie;Nicholas J Wilson;Rene de Waal Malefyt

  • IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.

    Jason R. Chan;Wendy Blumenschein;Erin Murphy;Caroline Diveu

  • WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27

    Stefan Pflanz;Linda Hibbert;Jeanine Mattson;Rency Rosales

  • Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

    Marcel B.M. Teunissen;Jan D. Bos;Cock W. Koomen;Rene de Waal Malefyt

  • TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation

    Yong Jun Liu;Vasilli Soumelis;Norihiko Watanabe;Tomoki Ito

  • Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

    A N McKenzie;J A Culpepper;R de Waal Malefyt;F Brière

  • Interleukin-10.

    Unknown

Frequent Co-Authors

Satwant K. Narula
Satwant K. Narula Weizenbaum-Institut
Terrill K. McClanahan
Terrill K. McClanahan MSD (United States)
Cox Terhorst
Cox Terhorst Beth Israel Deaconess Medical Center
Jonathan M. Spergel
Jonathan M. Spergel University of Pennsylvania
Hakon Hakonarson
Hakon Hakonarson Children's Hospital of Philadelphia
Robert A. Kastelein
Robert A. Kastelein MSD (United States)
David Artis
David Artis Cornell University
Atul K. Bhan
Atul K. Bhan Harvard University
Patrick M.A. Sleiman
Patrick M.A. Sleiman Children's Hospital of Philadelphia
Roland W. Herzog
Roland W. Herzog Indiana University

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