World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
10609
World Ranking
17083
National Ranking
7042

Overview

Paul F. Agris is affiliated with North Carolina State University in the United States and works primarily in the field of Biochemistry, Genetics and Molecular Biology. Their research focuses extensively on Molecular Biology, with additional contributions in Oncology, Genetics, and Molecular Medicine.

The scientist's work centers around several main topics including:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Peptidase Inhibition and Analysis
  • Genomics and Phylogenetic Studies
  • Bacterial Genetics and Biotechnology
  • Bacterial biofilms and quorum sensing

Paul F. Agris has published in a variety of venues, frequently contributing to:

  • Antibiotics
  • UNC Libraries
  • RNA
  • Journal of Molecular Biology
  • Antimicrobial Agents and Chemotherapy

Recent notable papers authored include:

  • Specificity in the biosynthesis of the universal tRNA nucleoside N6-threonylcarbamoyl adenosine (t6A)-TsaD is the gatekeeper, 2020, RNA
  • A Structural Basis for Restricted Codon Recognition Mediated by 2-thiocytidine in tRNA Containing a Wobble Position Inosine, 2020, Journal of Molecular Biology
  • Small-Molecule Antibiotics Inhibiting tRNA-Regulated Gene Expression Is a Viable Strategy for Targeting Gram-Positive Bacteria, 2020, Antimicrobial Agents and Chemotherapy
  • Physical Chemistry of a Single tRNA-Modified Nucleoside Regulates Decoding of the Synonymous Lysine Wobble Codon and Affects Type 2 Diabetes, 2022, The Journal of Physical Chemistry B
  • A New Promising Anti-Infective Agent Inhibits Biofilm Growth by Targeting Simultaneously a Conserved RNA Function That Controls Multiple Genes, 2021, Antibiotics

Frequently collaborating co-authors include:

  • Kathryn L. Sarachan
  • Sweta Vangaveti
  • Haein Kim
  • S. Ranganathan
  • Sheetal Ramachandran

Best Publications

  • The RNA modification database, RNAMDB: 2011 update

    William A. Cantara;Pamela F. Crain;Jef Rozenski;James A. McCloskey

  • tRNA's wobble decoding of the genome: 40 years of modification.

    Paul F. Agris;Franck A.P. Vendeix;William D. Graham

  • The role of modifications in codon discrimination by tRNA Lys UUU

    Frank V Murphy;Venki Ramakrishnan;Andrzej Malkiewicz;Paul F Agris

  • Decoding the genome: a modified view.

    Paul F. Agris

  • The importance of being modified: roles of modified nucleosides and Mg2+ in RNA structure and function.

    Paul F. Agris

  • tRNA's modifications bring order to gene expression.

    Estella M. Gustilo;Franck A.P. Vendeix;Paul F. Agris

  • Accurate Translation of the Genetic Code Depends on tRNA Modified Nucleosides

    Connie Yarian;Hannah Townsend;Wojciech Czestkowski;Elzbieta Sochacka

  • Bringing order to translation: the contributions of transfer RNA anticodon-domain modifications.

    Paul F Agris

  • Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines.

    Albert Weixlbaumer;Frank V Murphy;Agnieszka Dziergowska;Andrzej Malkiewicz

  • In vitro synthesis of 16S ribosomal RNA containing single base changes and assembly into a functional 30S ribosome

    W. Krzyzosiak;R. Denman;K. Nurse;W. Hellmann

  • Single atom modification (O → S) of tRNA confers ribosome binding

    S. Salman Ashraf;Elzbieta Sochacka;Robert Cain;Richard Guenther

  • Chemical and Conformational Diversity of Modified Nucleosides Affects tRNA Structure and Function

    Ville Y. P. Väre;Emily R. Eruysal;Amithi Narendran;Kathryn L. Sarachan

  • Chemistry and structure of modified uridines in the anticodon, wobble position of transfer RNA are determined by thiolation

    Hanna Sierzputowska-Gracz;Elzbieta Sochacka;Andrzej Malkiewicz;Kenneth Kuo

  • Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo.

    Brittany A. Elliott;Hsiang-Ting Ho;Srivathsan V. Ranganathan;Sweta Vangaveti

  • Celebrating wobble decoding: Half a century and still much is new.

    Paul F. Agris;Emily R. Eruysal;Amithi Narendran;Ville Y. P. Väre

  • Wobble position modified nucleosides evolved to select transfer RNA codon recognition: a modified-wobble hypothesis.

    P F Agris

  • Structural and functional roles of the N1- and N3-protons of psi at tRNA's position 39.

    Connie S. Yarian;Mufeed M. Basti;Robert J. Cain;Ghazala Ansari

  • Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNALysUUU species.

    Connie Yarian;Michal Marszalek;Elzbieta Sochacka;Andrzej Malkiewicz

  • Functional anticodon architecture of human tRNALys3 includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t6A.

    John W. Stuart;Zofia Gdaniec;Richard Guenther;Michal Marszalek

  • Biological function of 2-thiouridine in Escherichia coli glutamic acid transfer ribonucleic acid.

    Agris Pf;Söll D;Seno T

Frequent Co-Authors

Charles W. Gehrke
Charles W. Gehrke University of Missouri
Linda L. Spremulli
Linda L. Spremulli University of North Carolina at Chapel Hill
Dieter Söll
Dieter Söll Yale University
Alexander Deiters
Alexander Deiters University of Pittsburgh
Tina M. Henkin
Tina M. Henkin The Ohio State University
Wolf Dietrich Heyer
Wolf Dietrich Heyer University of California, Davis
Venki Ramakrishnan
Venki Ramakrishnan MRC Laboratory of Molecular Biology
Gérard Keith
Gérard Keith Centre national de la recherche scientifique, CNRS
Melanie Ehrlich
Melanie Ehrlich Tulane University
John W. Crabb
John W. Crabb Cleveland Clinic

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring careers in biology and biochemistry opens the door to numerous specialized fields in health and science. Today’s online learning options make it easier than ever to start or advance your career from anywhere.

Those interested in the intersection of biology, health, and nutrition might consider an online degree in nutrition. These programs provide foundational knowledge for careers in dietetics, public health, or wellness coaching.

For students aiming toward leadership roles in healthcare, pursuing one of the top online mha programs that are cahme accredited can lead to positions in hospital administration or health systems management. If your goal is advanced healthcare practice without the traditional clinical requirements, online dnp programs without clinicals offer flexibility for working professionals.

For those aspiring to the highest levels of leadership, a doctorate in healthcare management could pave the way to strategic roles, policy development, and academic careers. Each of these pathways complements studies in biology and biochemistry, creating diverse opportunities in the evolving world of healthcare and science.

Best Scientists Citing Paul F. Agris

Trending Scientists

Recently Published Articles