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Biology and Biochemistry

D-Index
54
Citations
7583
World Ranking
15859
National Ranking
6587

Research.com Recognitions

  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Linda L. Spremulli is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology.

Their work encompasses various subfields including Immunology, Clinical Biochemistry, Renewable Energy, Sustainability and the Environment, and Cellular and Molecular Neuroscience.

The main topics addressed across their body of research include:

  • RNA and protein synthesis mechanisms
  • Mitochondrial Function and Pathology
  • RNA modifications and cancer
  • ATP Synthase and ATPases Research
  • Metabolism and Genetic Disorders
  • Photosynthetic Processes and Mechanisms
  • RNA Research and Splicing

Spremulli's frequent co-authors have been:

  • Emine C. Koc
  • Md. Emdadul Haque
  • Brooke E. Christian
  • Rajendra K. Agrawal
  • William Burkhart

The majority of their publications have appeared in the venue UNC Libraries, with a smaller number published in Nature Communications.

Among the recent papers authored or co-authored by Spremulli are:

  • Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation, 2020, Nature Communications
  • The Small Subunit of the Mammalian Mitochondrial Ribosome: IDENTIFICATION OF THE FULL COMPLEMENT OF RIBOSOMAL PROTEINS PRESENT, 2021, UNC Libraries
  • The Large Subunit of the Mammalian Mitochondrial Ribosome: ANALYSIS OF THE COMPLEMENT OF RIBOSOMAL PROTEINS PRESENT, 2021, UNC Libraries
  • Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome, 2020, UNC Libraries
  • Interaction of Mammalian Mitochondrial Ribosomes with the Inner Membrane, 2021, UNC Libraries

In 2000, Linda L. Spremulli was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Structure of the mammalian mitochondrial ribosome reveals an expanded functional role for its component proteins.

    Manjuli R. Sharma;Emine C. Koc;Partha P. Datta;Timothy M. Booth

  • The Large Subunit of the Mammalian Mitochondrial Ribosome ANALYSIS OF THE COMPLEMENT OF RIBOSOMAL PROTEINS PRESENT

    Emine Cavdar Koc;William Burkhart;Kevin Blackburn;Mary B. Moyer

  • The Small Subunit of the Mammalian Mitochondrial Ribosome IDENTIFICATION OF THE FULL COMPLEMENT OF RIBOSOMAL PROTEINS PRESENT

    Emine Cavdar Koc;William Burkhart;Kevin Blackburn;Arthur Moseley

  • Mechanism of protein biosynthesis in mammalian mitochondria.

    Brooke E. Christian;Linda L. Spremulli

  • A new face on apoptosis: Death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins

    Emine Cavdar Koc;Asoka Ranasinghe;William Burkhart;Kevin Blackburn

  • Identification of Mammalian Mitochondrial Translational Initiation Factor 3 and Examination of Its Role in Initiation Complex Formation with Natural mRNAs

    Emine Cavdar Koc;Linda L. Spremulli

  • Unconventional decoding of the AUA codon as methionine by mitochondrial tRNAMet with the anticodon f5CAU as revealed with a mitochondrial in vitro translation system

    Chie Takemoto;Linda L. Spremulli;Lisa A. Benkowski;Takuya Ueda

  • Interaction of Mammalian Mitochondrial Ribosomes with the Inner Membrane

    Meiqin Liu;Linda Spremulli

  • A Single Mammalian Mitochondrial Translation Initiation Factor Functionally Replaces Two Bacterial Factors

    Rahul Gaur;Domenick Grasso;Partha P. Datta;P.D.V. Krishna

  • Purification and characterization of a ribosome dissociation factor (eukaryotic initiation factor 6) from wheat germ.

    David W Russell;L. L. Spremulli

  • Bovine mitochondrial protein synthesis elongation factors. Identification and initial characterization of an elongation factor Tu-elongation factor Ts complex.

    C J Schwartzbach;L L Spremulli

  • Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase.

    James M. Bullard;Ying Chun Cai;Borries Demeler;Linda L. Spremulli

  • CLONING, SEQUENCE ANALYSIS AND EXPRESSION OF MAMMALIAN MITOCHONDRIAL PROTEIN SYNTHESIS ELONGATION FACTOR TU

    Velinda L. Woriax;Will Burkhart;Linda L. Spremulli

  • Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor

    Yuelin Zhang;Linda L. Spremulli

  • Initiation and Elongation Factors in Mammalian Mitochondrial Protein Biosynthesis

    Linda L Spremulli;Angie Coursey;Tomas Navratil;Senyene Eyo Hunter

  • The effect of mutated mitochondrial ribosomal proteins S16 and S22 on the assembly of the small and large ribosomal subunits in human mitochondria

    Md. Emdadul Haque;Domenick Grasso;Chaya Miller;Linda L. Spremulli

  • Evidence for an active role of IF3mt in the initiation of translation in mammalian mitochondria.

    Brooke E. Christian;Linda L. Spremulli

  • A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins.

    Emine Cavdar Koc;William Burkhart;Kevin Blackburn;Arthur Moseley

  • Purification and properties of a Met-tRNAf binding factor from wheat germ

    Linda L. Spremulli;Ben J. Walthall;Sandra R. Lax;Joanne M. Ravel

  • Interaction of Mitochondrial Elongation Factor Tu with Aminoacyl-tRNA and Elongation Factor Ts

    Ying Chun Cai;James M. Bullard;Nancy L. Thompson;Linda L. Spremulli

Frequent Co-Authors

Rajendra K. Agrawal
Rajendra K. Agrawal University at Albany, State University of New York
Takuya Ueda
Takuya Ueda University of Tokyo
David W. Russell
David W. Russell University of Washington
Yuelin Zhang
Yuelin Zhang University of British Columbia
Hua-Xin Liao
Hua-Xin Liao Duke University
Paul F. Agris
Paul F. Agris North Carolina State University
Kimitsuna Watanabe
Kimitsuna Watanabe National Institute of Advanced Industrial Science and Technology
Lan Ma
Lan Ma Fudan University
Ann Saada
Ann Saada Hebrew University of Jerusalem
Larry Simpson
Larry Simpson University of California, Los Angeles

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