2012 - Fellow of the American Academy of Arts and Sciences
RNA editing, Guide RNA, Kinetoplast, RNA and Genetics are his primary areas of study. His RNA editing research incorporates elements of Nucleic acid sequence, Trypanosoma brucei and Mitochondrion. He interconnects Minicircle, Molecular biology and Cytochrome c oxidase subunit III in the investigation of issues within Kinetoplast.
The various areas that Larry Simpson examines in his Molecular biology study include Leishmania tarentolae and Cell biology. In his research, Protein secondary structure is intimately related to Nucleotide, which falls under the overarching field of RNA. In Genetics, he works on issues like Computational biology, which are connected to Small RNA.
The scientist’s investigation covers issues in RNA editing, Genetics, Molecular biology, RNA and Guide RNA. In his study, which falls under the umbrella issue of RNA editing, Transfer RNA is strongly linked to Mitochondrion. His Genetics study frequently draws connections to other fields, such as Leishmania.
His Molecular biology research incorporates themes from Trypanosoma brucei, Crithidia fasciculata, DNA, Kinetoplast and Nuclear DNA. His work carried out in the field of Kinetoplast brings together such families of science as Leishmania tarentolae, Biophysics and Protozoa. RNA is closely attributed to Peptide sequence in his study.
Larry Simpson mainly focuses on RNA editing, RNA, Guide RNA, Biochemistry and Trypanosoma brucei. His RNA editing study is related to the wider topic of Genetics. His Genetics study which covers Computational biology that intersects with Mature messenger RNA and Sequence.
His studies in RNA integrate themes in fields like Molecular biology and Conserved sequence. His Molecular biology study combines topics from a wide range of disciplines, such as RNA silencing and Cell biology. His study in Trypanosoma brucei is interdisciplinary in nature, drawing from both Transferase, Tsetse fly, Peptide sequence, Leishmania and Trypanosoma equiperdum.
His primary scientific interests are in RNA editing, RNA, Guide RNA, Molecular biology and Intron. Larry Simpson has included themes like Trypanosoma brucei and Trypanosoma in his RNA editing study. His Trypanosoma brucei study is associated with Genetics.
His RNA research entails a greater understanding of Biochemistry. His biological study spans a wide range of topics, including RNA interference and RNA silencing. His Intron research focuses on RNA-dependent RNA polymerase and how it relates to RNA ligase.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
A model for RNA editing in kinetoplastid mitochondria: "guide" RNA molecules transcribed from maxicircle DNA provide the edited information.
Beat Blum;Norbert Bakalara;Larry Simpson.
Cell (1990)
Strains and clones of Trypanosoma cruzi can be characterized by pattern of restriction endonuclease products of kinetoplast DNA minicircles.
C Morel;E Chiari;E P Camargo;D M Mattei.
Proceedings of the National Academy of Sciences of the United States of America (1980)
The Mitochondrial Genome of Kinetoplastid Protozoa: Genomic Organization, Transcription, Replication, and Evolution
Larry Simpson.
Annual Review of Microbiology (1987)
Sensitive detection and schizodeme classification of Trypanosoma cruzi cells by amplification of kinetoplast minicircle DNA sequences: use in diagnosis of Chagas' disease
Nancy R. Sturm;Wim Degrave;Carlos Morel;Larry Simpson.
Molecular and Biochemical Parasitology (1989)
Polymerase chain reaction amplification of Trypanosoma cruzi kinetoplast minicircle DNA isolated from whole blood lysates: diagnosis of chronic Chagas' disease.
Herbert A. Avila;David S. Sigman;Lee M. Cohen;Robert C. Millikan.
Molecular and Biochemical Parasitology (1991)
Guide RNAs in kinetoplastid mitochondria have a nonencoded 3' oligo(U) tail involved in recognition of the preedited region.
Beat Blum;Larry Simpson.
Cell (1990)
Kinetoplast DNA minicircles encode guide RNAs for editing of cytochrome oxidase subunit III mRNA
Nancy R. Sturm;Larry Simpson.
Cell (1990)
RNA editing and the mitochondrial cryptogenes of kinetoplastid protozoa
Larry Simpson;Janet Shaw.
Cell (1989)
Phylogeny of trypanosomes as inferred from the small and large subunit rRNAs: implications for the evolution of parasitism in the trypanosomatid protozoa
Dmitri A. Maslov;Julius Lukeš;Milan Jirku;Larry Simpson.
Molecular and Biochemical Parasitology (1996)
Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons
Janet M. Shaw;Jean E. Feagin;Kenneth Stuart;Larry Simpson;Larry Simpson.
Cell (1988)
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