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D-Index & Metrics

Genetics

D-Index
70
Citations
15102
World Ranking
2288
National Ranking
1025

Research.com Recognitions

  • 2012 - Fellow of the American Academy of Arts and Sciences

Overview

Larry Simpson is affiliated with the University of California, Los Angeles in the United States. Their research spans several fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Agricultural and Biological Sciences. Within these main fields, the focus extends to subfields such as Molecular Biology, Organic Chemistry, Plant Science, Epidemiology, and Ecology, Evolution, Behavior and Systematics.

The scientist's work covers multiple topics, including:

  • Cancer therapeutics and mechanisms
  • Biochemical and Molecular Research
  • Trypanosoma species research and implications
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Synthesis of β-Lactam Compounds
  • Synthesis and biological activity

Their recent publications include the following papers:

  • Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes (2020) published in Trends in Parasitology
  • Mutagenesis of Intrinsically Disordered Domain Impacts Topoisomerase II⍺ Catalytic Activity (2025) published in Preprints.org
  • Liparis barbata Lindl. (Orchidaceae) - new to the flora of Australia (2021) published in Austrobaileya A Journal of Plant Systematics
  • Proteomics and electron microscopic characterization of the unusual mitochondrial ribosome-related 45S complex in Leishmania tarentolae (2020) published in UNC Libraries
  • Mutagenesis of Intrinsically Disordered Domain Impacts Topoisomerase IIα Catalytic Activity (2025) published in International Journal of Molecular Sciences

Frequent publication venues include:

  • Trends in Parasitology
  • Preprints.org
  • Austrobaileya A Journal of Plant Systematics
  • UNC Libraries
  • International Journal of Molecular Sciences

The scientist has collaborated regularly with several researchers, including:

  • Dmitri Maslov
  • Justin Chang
  • Addison K O'Brian
  • Aline Thomas
  • Mattalyn R. Hardin

Larry Simpson was recognized as a Fellow of the American Academy of Arts and Sciences in 2012.

Best Publications

  • A model for RNA editing in kinetoplastid mitochondria: "guide" RNA molecules transcribed from maxicircle DNA provide the edited information.

    Beat Blum;Norbert Bakalara;Larry Simpson

  • Strains and clones of Trypanosoma cruzi can be characterized by pattern of restriction endonuclease products of kinetoplast DNA minicircles.

    C Morel;E Chiari;E P Camargo;D M Mattei

  • The Mitochondrial Genome of Kinetoplastid Protozoa: Genomic Organization, Transcription, Replication, and Evolution

    Larry Simpson

  • Sensitive detection and schizodeme classification of Trypanosoma cruzi cells by amplification of kinetoplast minicircle DNA sequences: use in diagnosis of Chagas' disease

    Nancy R. Sturm;Wim Degrave;Carlos Morel;Larry Simpson

  • Polymerase chain reaction amplification of Trypanosoma cruzi kinetoplast minicircle DNA isolated from whole blood lysates: diagnosis of chronic Chagas' disease.

    Herbert A. Avila;David S. Sigman;Lee M. Cohen;Robert C. Millikan

  • Phylogeny of trypanosomes as inferred from the small and large subunit rRNAs: implications for the evolution of parasitism in the trypanosomatid protozoa

    Dmitri A. Maslov;Julius Lukeš;Milan Jirku;Larry Simpson

  • Kinetoplast DNA minicircles encode guide RNAs for editing of cytochrome oxidase subunit III mRNA

    Nancy R. Sturm;Larry Simpson

  • Guide RNAs in kinetoplastid mitochondria have a nonencoded 3' oligo(U) tail involved in recognition of the preedited region.

    Beat Blum;Larry Simpson

  • RNA editing and the mitochondrial cryptogenes of kinetoplastid protozoa

    Larry Simpson;Janet Shaw

  • Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons

    Janet M. Shaw;Jean E. Feagin;Kenneth Stuart;Larry Simpson;Larry Simpson

  • Detection of Trypanosoma cruzi in blood specimens of chronic chagasic patients by polymerase chain reaction amplification of kinetoplast minicircle DNA: comparison with serology and xenodiagnosis.

    H A Avila;J B Pereira;O Thiemann;E De Paiva

  • The Kinetoplast of the Hernoflagellates

    Larry Simpson

  • Uridine insertion/deletion RNA editing in trypanosome mitochondria: A complex business

    Larry Simpson;Sandro Sbicego;Ruslan Aphasizhev

  • Kinetoplastid mitochondria contain functional tRNAs which are encoded in nuclear DNA and also contain small mlnltircJe and maxicircle transcripts of unknown function

    A M Simpson;Y Suyama;H Dewes;D A Campbell

  • Evolution of RNA editing in trypanosome mitochondria

    Larry Simpson;Otavio H. Thiemann;Nicholas J. Savill;Juan D. Alfonzo

  • C to U editing of the anticodon of imported mitochondrial tRNA(Trp) allows decoding of the UGA stop codon in Leishmania tarentolae

    Juan D. Alfonzo;Valerie Blanc;Antonio M. Estévez;Mary Anne T. Rubio

  • Kinetoplast DNA in trypanosomid flagellates.

    Larry Simpson

  • The polarity of editing within a multiple gRNA-mediated domain is due to formation of anchors for upstream gRNAs by downstream editing

    Dmitri A. Maslov;Larry Simpson

  • Sequences of six genes and several open reading frames in the kinetoplast maxicircle DNA of Leishmania tarentolae.

    V F de la Cruz;N Neckelmann;L Simpson

  • Isolation of a U‐insertion/deletion editing complex from Leishmania tarentolae mitochondria

    Ruslan Aphasizhev;Inna Aphasizheva;Robert E. Nelson;Guanghan Gao

Frequent Co-Authors

Dmitri A. Maslov
Dmitri A. Maslov University of California, Riverside
David A. Campbell
David A. Campbell University of California, Los Angeles
Nancy R. Sturm
Nancy R. Sturm University of California, Los Angeles
James A. Lake
James A. Lake University of California, Los Angeles
Rajendra K. Agrawal
Rajendra K. Agrawal University at Albany, State University of New York
David S. Sigman
David S. Sigman University of California, Los Angeles
Julius Lukeš
Julius Lukeš Czech Academy of Sciences
Linda L. Spremulli
Linda L. Spremulli University of North Carolina at Chapel Hill
Z. Hong Zhou
Z. Hong Zhou University of California, Los Angeles
Kenneth Stuart
Kenneth Stuart University of Washington

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