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Nigel D. F. Grindley

Nigel D. F. Grindley

D-Index & Metrics

Genetics

D-Index
62
Citations
10914
World Ranking
3004
National Ranking
1310

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2006 - Fellow of the Royal Society, United Kingdom
  • 1987 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Nigel D. F. Grindley is a researcher affiliated with Yale University in the United States, specializing in the fields of Biochemistry, Genetics and Molecular Biology as well as Materials Science. Their work spans molecular biology and materials chemistry, contributing to the understanding of fundamental biological processes and chemical materials.

The main topics of their research focus on DNA and nucleic acid chemistry, advanced biosensing and bioanalysis techniques, and photochromic and fluorescence chemistry. These areas indicate a multidisciplinary approach combining biological molecules with innovative chemical methods and sensing technologies.

Frequent collaborators in their work include Weikai Li, Satwik Kamtekar, Yong Xiong, Gary J. Sarkis, and Thomas A. Steitz. Collaboration with these co-authors highlights engagement in diverse research projects across molecular biology and biochemistry.

This scientist's recognized contributions have been acknowledged through fellowships in notable scientific societies. These honors include:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2007
  • Fellow of the Royal Society, United Kingdom, 2006
  • Fellow of John Simon Guggenheim Memorial Foundation, 1987

Best Publications

  • Mechanisms of Site-Specific Recombination*

    Nigel D.F. Grindley;Katrine L. Whiteson;Phoebe A. Rice

  • The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

    V. Derbyshire;N. D. F. Grindley;C. M. Joyce

  • Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.

    A. H. Polesky;T. A. Steitz;N. D. F. Grindley;C. M. Joyce

  • Method for determining whether a gene of Escherichia coli is essential: application to the polA gene.

    C. M. Joyce;N. D. F. Grindley

  • Transpositional recombination in prokaryotes.

    Nigel D. F. Grindley;Randall R. Reed

  • Conformational transitions in DNA polymerase I revealed by single-molecule FRET.

    Yusdi Santoso;Catherine M. Joyce;Olga Potapova;Ludovic Le Reste

  • A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides.

    Mekbib Astatke;Kimmie Ng;Nigel D. F. Grindley;Catherine M. Joyce

  • Transposon-mediated site-specific recombination in vitro: DNA cleavage and protein-DNA linkage at the recombination site

    R.R. Reed;N.D.F. Grindley

  • Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.

    A. H. Polesky;M. E. Dahlberg;S. J. Benkovic;N. D. F. Grindley

  • Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli.

    Catherine M. Joyce;Nigel D. F. Grindley

  • Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I.

    C.M. Joyce;W.S. Kelley;N.D. Grindley

  • Molecular Studies of R Factor Compatibility Groups

    N. D. F. Grindley;G. O. Humphreys;E. S. Anderson

  • Transposon-mediated site-specific recombination: Identification of three binding sites for resolvase at the res sites of γδ and Tn 3

    N.D.F. Grindley;M.R. Lauth;R.G. Wells;R.J. Wityk

  • Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment).

    Mekbib Astatke;Nigel D.F. Grindley;Catherine M. Joyce

  • IS1 insertion generates duplication of a nine base pair sequence at its target site

    Nigel D.F. Grindley

  • Genetic and DNA sequence analysis of the kanamycin resistance transposon Tn903

    Nigel D. F. Grindley;Catherine M. Joyce

  • A simple and efficient procedure for saturation mutagenesis using mixed oligodeoxynucleotides

    Keith M. Derbyshire;Joseph J. Salvo;Nigel D.F. Grindley

  • Fingers-Closing and Other Rapid Conformational Changes in DNA Polymerase I (Klenow Fragment) and Their Role in Nucleotide Selectivity†

    Catherine M. Joyce;Olga Potapova;Angela M. DeLucia;Xuanwei Huang

  • R factor compatibility groups.

    N. D. F. Grindley;June N. Grindley;E. S. Anderson

  • Sequence analysis at IS1 insertion sites: models for transposition.

    N. D. F. Grindley;D. J. Sherratt

Frequent Co-Authors

Thomas A. Steitz
Thomas A. Steitz Yale University
John F. Marko
John F. Marko Northwestern University
Graham F. Hatfull
Graham F. Hatfull University of Pittsburgh
Phoebe A. Rice
Phoebe A. Rice University of Chicago
Paul S. Freemont
Paul S. Freemont Imperial College London
Yong Xiong
Yong Xiong Yale University
Rebecca G. Wells
Rebecca G. Wells University of Pennsylvania
Jorge E. Galán
Jorge E. Galán Yale University
Stephen J. Elledge
Stephen J. Elledge Harvard University
Robert Landick
Robert Landick University of Wisconsin–Madison

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