World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
18988
World Ranking
6612
National Ranking
3079

Overview

Rebecca G. Wells is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Surgery, Cell Biology, Hepatology, Molecular Biology, and Oncology.

The scientist's work covers several main topics including Pediatric Hepatobiliary Diseases and Treatments, Liver physiology and pathology, Cellular Mechanics and Interactions, Liver Disease Diagnosis and Treatment, Gallbladder and Bile Duct Disorders, Pancreatic and Hepatic Oncology Research, and Pancreatitis Pathology and Treatment.

Recent publications illustrate a focus on cancer biology and liver disease mechanisms. Notable papers include "Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations" published in 2021 in Cancer Cell; "Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts", also from 2021 in the Journal of Clinical Investigation; and "Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis" published in 2022 in Nature. More recent studies are "Stiff matrix induces exosome secretion to promote tumour growth" from 2023 in Nature Cell Biology and "Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver" published in 2024 in Nature.

Rebecca G. Wells has collaborated frequently with several researchers, including Jessica Llewellyn, Paul A. Janmey, Dongning Chen, Neil D. Theise, and Kapish Gupta. These collaborations reflect an intersection of expertise relevant to their research interests.

Frequent publication venues for Wells include bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Journal of Hepatology, Nature, and Scientific Reports, indicating engagement with a range of prestigious scientific journals and preprint platforms.

Best Publications

  • The role of matrix stiffness in regulating cell behavior.

    Rebecca G. Wells

  • Matrix Stiffness Modulates Proliferation, Chemotherapeutic Response and Dormancy in Hepatocellular Carcinoma Cells

    Joerg Schrader;Joerg Schrader;Timothy T. Gordon-Walker;Rebecca L. Aucott;Marielle van Deemter

  • Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

    Penelope C. Georges;Jia Ji Hui;Zoltan Gombos;Margaret E. McCormick

  • Robust cellular reprogramming occurs spontaneously during liver regeneration

    Kilangsungla Yanger;Yiwei Zong;Lara R. Maggs;Suzanne N. Shapira

  • Tissue mechanics and fibrosis

    Rebecca G. Wells

  • Transforming growth factor-β and substrate stiffness regulate portal fibroblast activation in culture

    Zhaodong Li;Jonathan A. Dranoff;Erick P. Chan;Masayuki Uemura

  • Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

    Abby L. Olsen;Steven A. Bloomer;Erick P. Chan;Marianna D. A. Gaça

  • Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation

    Elisabeth E. Charrier;Katarzyna Pogoda;Katarzyna Pogoda;Rebecca G. Wells;Paul A. Janmey

  • Structure and Distribution of an Unrecognized Interstitium in Human Tissues

    Petros C. Benias;Petros C. Benias;Rebecca G. Wells;Bridget Sackey-Aboagye;Heather Klavan

  • The high affinity Na+/glucose cotransporter. Re-evaluation of function and distribution of expression.

    Wen-Sen Lee;Y. Kanai;R. G. Wells;M. A. Hediger

  • Portal fibroblasts: Underappreciated mediators of biliary fibrosis.

    Jonathan A. Dranoff;Rebecca G. Wells

  • Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers.

    Hailong Wang;A.S. Abhilash;Christopher S. Chen;Rebecca G. Wells

  • The Precarious State of the Liver After a Fontan Operation: Summary of a Multidisciplinary Symposium

    Jack Rychik;Jack Rychik;Gruschen Veldtman;Elizabeth Rand;Elizabeth Rand;Pierre Russo;Pierre Russo

  • Biliary Atresia: Clinical and Research Challenges for the Twenty‐First Century

    Jorge A. Bezerra;Rebecca G. Wells;Cara L. Mack;Saul J. Karpen

  • The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis.

    Rebecca G Wells

  • Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases.

    Rebecca G. Wells;Matthias A. Hediger

  • Smads 2 and 3 Are Differentially Activated by Transforming Growth Factor-β (TGF-β) in Quiescent and Activated Hepatic Stellate Cells CONSTITUTIVE NUCLEAR LOCALIZATION OF Smads IN ACTIVATED CELLS IS TGF-β-INDEPENDENT

    Chenghai Liu;Marianna D.A. Gaça;E. Scott Swenson;Vincent F. Vellucci

  • V. TGF-β signaling pathways

    Rebecca G. Wells

  • Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations.

    Silvia Affo;Ajay Nair;Francesco Brundu;Aashreya Ravichandra

  • Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter

    R. G. Wells;A. M. Pajor;Y. Kanai;E. Turk

Frequent Co-Authors

Paul A. Janmey
Paul A. Janmey University of Pennsylvania
Christopher S. Chen
Christopher S. Chen Boston University
Matthias A. Hediger
Matthias A. Hediger University of Bern
Wen Sen Lee
Wen Sen Lee Taipei Medical University
Jason A. Burdick
Jason A. Burdick University of Colorado Boulder
Yoshikatsu Kanai
Yoshikatsu Kanai Osaka University
John P. Iredale
John P. Iredale University of Bristol
Vivek B. Shenoy
Vivek B. Shenoy University of Pennsylvania
Robert F. Schwabe
Robert F. Schwabe Columbia University
Dennis E. Discher
Dennis E. Discher University of Pennsylvania

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