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Immunology

D-Index
48
Citations
11920
World Ranking
4398
National Ranking
172

Overview

Mirjam Kool is affiliated with Erasmus University Rotterdam in the Netherlands. Their research primarily focuses on medicine, with significant contributions in immunology and microbiology.

Their work encompasses several subfields, notably pulmonary and respiratory medicine, immunology, physiology, molecular biology, and hepatology. The main topics addressed in their research include pulmonary hypertension research and treatments, interstitial lung diseases and idiopathic pulmonary fibrosis, sarcoidosis and beryllium toxicity research, immunotherapy and immune responses, liver disease and transplantation, IL-33, ST2, and ILC pathways, as well as immune cell function and interaction.

Kool has published in various scientific venues, with frequent publications in the International Journal of Molecular Sciences, Frontiers in Immunology, Respiratory Research, Nature Communications, and the Journal of Clinical Medicine.

  • Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: An Immunological Perspective, 2020, Journal of Clinical Medicine
  • Plasma markers in pulmonary hypertension subgroups correlate with patient survival, 2021, Respiratory Research
  • Design of a randomized controlled trial to evaluate effectiveness of methotrexate versus prednisone as first-line treatment for pulmonary sarcoidosis: the PREDMETH study, 2020, BMC Pulmonary Medicine
  • Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations, 2023, Nature Communications
  • DNGR1-Cre-mediated Deletion of Tnfaip3/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice, 2020, American Journal of Respiratory Cell and Molecular Biology

Frequent coauthors of Mirjam Kool include Rudi W. Hendriks, Karin A. Boomars, Thomas Koudstaal, Denise van Uden, and Jennifer A. C. van Hulst.

Best Publications

  • Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

    Mirjam Kool;Thomas Soullié;Menno van Nimwegen;Monique A.M. Willart

  • Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

    Mirjam Kool;Virginie Pétrilli;Thibaut De Smedt;Aline Rolaz

  • Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.

    Marco Idzko;Hamida Hammad;Menno van Nimwegen;Mirjam Kool

  • Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

    Hamida Hammad;Maud Plantinga;Kim Deswarte;Philippe Pouliot

  • Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells

    Corine H. GeurtsvanKessel;Monique A.M. Willart;Leonie S. van Rijt;Femke Muskens

  • Inflammation and immunity in IPF pathogenesis and treatment

    P. Heukels;C.C. Moor;J.H. von der Thüsen;M.S. Wijsenbeek

  • Mechanism of action of clinically approved adjuvants

    Bart N Lambrecht;Mirjam Kool;Monique A M Willart;Hamida Hammad

  • An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

    Mirjam Kool;Monique A.M. Willart;Menno van Nimwegen;Ingrid Bergen

  • Alum adjuvant: some of the tricks of the oldest adjuvant

    Mirjam Kool;Kaat Fierens;Bart N. Lambrecht

  • Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function

    Marco Idzko;Hamida Hammad;Menno van Nimwegen;Mirjam Kool

  • Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung

    Ismé M. de Kleer;Mirjam Kool;Marjolein J.W. de Bruijn;Monique Willart

  • A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

    Mourad Matmati;Peggy Jacques;Jonathan Maelfait;Jonathan Maelfait;Eveline Verheugen

  • Prevention of Th2-Like Cell Responses by Coadministration of IL-12 and IL-18 Is Associated with Inhibition of Antigen-Induced Airway Hyperresponsiveness, Eosinophilia, and Serum IgE Levels

    Hofstra Cl;Van Ark I;Hofman G;Kool M

  • Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells

    Hamida Hammad;Mirjam Kool;Thomas Soullié;Shuh Narumiya

  • IFN-γ–Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells

    Joris Ramstein;Caroline E. Broos;Laura J. Simpson;K. Mark Ansel

  • The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

    Mirjam Kool;Geert van Loo;Wim Waelput;Sofie De Prijck

  • Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses.

    Frank A Redegeld;Maurice W van der Heijden;Mirjam Kool;Bianca M Heijdra

  • An Anti-Inflammatory Role for Plasmacytoid Dendritic Cells in Allergic Airway Inflammation

    Mirjam Kool;Menno van Nimwegen;Monique A. M. Willart;Femke Muskens

  • Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection

    Hermelijn H. Smits;Hermelijn H. Smits;Hamida Hammad;Menno van Nimwegen;Thomas Soullie

  • A20/Tumor Necrosis Factor α-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models

    Tridib Das;Zhongli Chen;Rudi W. Hendriks;Mirjam Kool

  • Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function

    Marco Idzko;Hamida Hammad;Menno van Nimwegen;Mirjam Kool

Frequent Co-Authors

Bart N. Lambrecht
Bart N. Lambrecht Ghent University
Rudi W. Hendriks
Rudi W. Hendriks Erasmus University Rotterdam
Hamida Hammad
Hamida Hammad Ghent University
Henk C. Hoogsteden
Henk C. Hoogsteden Erasmus University Rotterdam
Frans P. Nijkamp
Frans P. Nijkamp Utrecht University
Frank A. Redegeld
Frank A. Redegeld Utrecht University
Aletta D. Kraneveld
Aletta D. Kraneveld Utrecht University
Geert van Loo
Geert van Loo Ghent University
Louis Boon
Louis Boon University of Amsterdam
Rudi Beyaert
Rudi Beyaert Ghent University

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Related Online Degrees & Career Pathways

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Combining immunology education with practical nursing credentials can open doors to impactful roles in healthcare, research, and patient advocacy.

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