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Microbiology

D-Index
89
Citations
26657
World Ranking
726
National Ranking
340

Medicine

D-Index
93
Citations
27905
World Ranking
10986
National Ranking
5650

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Michael J. Holtzman is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a substantive focus on Infectious Diseases, Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, and Neurology.

Holtzman's recent scholarly contributions include several papers published in notable journals throughout 2020. These papers are:

  • Potently neutralizing and protective human antibodies against SARS-CoV-2, 2020, Nature
  • SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function, 2020, Nature Immunology
  • A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2, 2020, Cell
  • A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies, 2020, Cell
  • Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice, 2020, Cell Host & Microbe

The frequent co-authors collaborating with Holtzman include Shamus P. Keeler, Yong Zhang, Kangyun Wu, Michael Diamond, and Derek E. Byers. These collaborations highlight a network of researchers working across related biomedical fields.

Holtzman's body of work has been published repeatedly in several venues, with bioRxiv (Cold Spring Harbor Laboratory) being the most common outlet. Other frequent publication venues include Nature Communications, Cell, Cell Reports, and The Journal of Immunology.

The main research topics addressed by Holtzman focus notably on SARS-CoV-2 and COVID-19 research, COVID-19 clinical research studies, neonatal respiratory health research, respiratory viral infections research, IL-33, ST2, and ILC pathways, neuroscience and neuropharmacology research, as well as long-term effects of COVID-19.

Their research intersects fields critical to understanding and managing respiratory illnesses and immunological responses, including molecular mechanisms and clinical implications related to infectious diseases and respiratory medicine.

Michael J. Holtzman has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2013. They are also a member of the Association of American Physicians.

Best Publications

  • Potently neutralizing and protective human antibodies against SARS-CoV-2.

    Seth J. Zost;Pavlo Gilchuk;James Brett Case;Elad Binshtein

  • SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.

    Emma S. Winkler;Adam L. Bailey;Natasha M. Kafai;Sharmila Nair

  • Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells

    Brian T. Edelson;Wumesh Kc;Richard Juang;Masako Kohyama

  • Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.

    Edy Y Kim;John T Battaile;Anand C Patel;Yingjian You

  • A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.

    Ahmed O. Hassan;Natasha M. Kafai;Igor P. Dmitriev;Julie M. Fox

  • O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans

    J. Seltzer;B. G. Bigby;M. Stulbarg;M. J. Holtzman

  • The microbial metabolite desaminotyrosine protects from influenza through type I interferon

    Ashley L. Steed;George P. Christophi;Gerard E. Kaiko;Lulu Sun

  • A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.

    Ahmed O. Hassan;James Brett Case;Emma S. Winkler;Larissa B. Thackray

  • Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells

    Aida Ibricevic;Andrew Pekosz;Michael J. Walter;Celeste Newby

  • Importance of airway inflammation for hyperresponsiveness induced by ozone.

    M. J. Holtzman;Leonardo Fabbri;P. M. O'Byrne;B. D. Gold

  • Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease

    Derek E Byers;Jennifer Alexander-Brett;Anand C Patel;Eugene Agapov

  • Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and Alpha/Beta Interferon Responsiveness

    Mindy S. Lo;Robert M. Brazas;Michael J. Holtzman

  • CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.

    Jeffrey W Tyner;Osamu Uchida;Naohiro Kajiwara;Edy Y Kim

  • Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea.

    J A Hunter;W E Finkbeiner;J A Nadel;E J Goetzl

  • Arachidonic acid metabolism. Implications of biological chemistry for lung function and disease.

    Michael J. Holtzman

  • Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals

    Jeffrey W. Tyner;Edy Y. Kim;Kyotaro Ide;Mark R. Pelletier

  • Effect of ozone on bronchial reactivity in atopic and nonatopic subjects.

    Michael J. Holtzman;Joseph H. Cunningham;James R. Sheller;Gernot B. Irsigler

  • Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure.

    P. M. O'Byrne;E. H. Walters;B. D. Gold;H. A. Aizawa

  • Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma

    Deepak Sampath;Mario Castro;Dwight C. Look;Michael J. Holtzman

  • Stat1 depends on transcriptional synergy with Sp1.

    Dwight C. Look;Mark R. Pelletier;Rose M. Tidwell;William T. Roswit

Frequent Co-Authors

Mario Castro
Mario Castro Washington University in St. Louis
Steven L. Brody
Steven L. Brody Washington University in St. Louis
Leonardo M. Fabbri
Leonardo M. Fabbri University of Ferrara
Michael S. Diamond
Michael S. Diamond Washington University in St. Louis
Paul M. O'Byrne
Paul M. O'Byrne McMaster University
Thaddeus S. Stappenbeck
Thaddeus S. Stappenbeck Washington University in St. Louis
Homer A. Boushey
Homer A. Boushey University of California, San Francisco
Jay A. Nadel
Jay A. Nadel University of California, San Francisco
Marco Colonna
Marco Colonna Washington University in St. Louis
Daved H. Fremont
Daved H. Fremont Washington University in St. Louis

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