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D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
38538
World Ranking
2645
National Ranking
1375

Overview

Thaddeus S. Stappenbeck is affiliated with Washington University in St. Louis in the United States. Their research spans multiple fields with a primary focus on Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology.

Their subfields of study include Immunology, Infectious Diseases, Molecular Biology, Genetics, and Epidemiology. The main topics covered in their work involve Gut microbiota and health, Inflammatory Bowel Disease, IL-33, ST2, and ILC Pathways, Clostridium difficile and Clostridium perfringens research, Parasitic Infections and Diagnostics, Immune Cell Function and Interaction, and Viral gastroenteritis research and epidemiology.

Thaddeus S. Stappenbeck has contributed significantly to scholarly journals, frequently publishing in Gastroenterology, bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, Inflammatory Bowel Diseases, and Science.

Their recent notable papers include:

  • Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice, 2021, Science
  • The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis, 2020, Cell
  • A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19, 2020, PLoS Biology
  • Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation, 2021, Cell Host & Microbe
  • Organoids in gastrointestinal diseases: from experimental models to clinical translation, 2022, Gut

Frequent co-authors collaborating with Stappenbeck include Ta-Chiang Liu, Dermot McGovern, Kelli L. VanDussen, Talin Haritunians, and Qiuhe Lu.

Best Publications

  • Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.

    Jason Lloyd-Price;Jason Lloyd-Price;Cesar Arze;Ashwin N. Ananthakrishnan;Melanie Schirmer;Melanie Schirmer

  • A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

    Mahesh S. Desai;Mahesh S. Desai;Anna M. Seekatz;Nicole M. Koropatkin;Nobuhiko Kamada

  • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

    Ken Cadwell;John Y. Liu;Sarah L. Brown;Hiroyuki Miyoshi

  • Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells.

    Thaddeus S. Stappenbeck;Lora V. Hooper;Jeffrey I. Gordon

  • Disease-specific alterations in the enteric virome in inflammatory bowel disease.

    Jason M. Norman;Scott A. Handley;Megan T. Baldridge;Lindsay Droit

  • Angiogenins: a new class of microbicidal proteins involved in innate immunity

    Lora V. Hooper;Thaddeus S. Stappenbeck;Chieu V. Hong;Jeffrey I. Gordon

  • Peripheral education of the immune system by colonic commensal microbiota

    Stephanie K. Lathrop;Seth M. Bloom;Sindhuja M. Rao;Katherine Nutsch

  • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

    Ken Cadwell;Khushbu K. Patel;Nicole S. Maloney;Ta Chiang Liu

  • Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells

    Brian T. Edelson;Wumesh Kc;Richard Juang;Masako Kohyama

  • Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury.

    Sarah L. Pull;Jason M. Doherty;Jason C. Mills;Jeffrey I. Gordon

  • In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

    Hiroyuki Miyoshi;Thaddeus S Stappenbeck

  • The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

    Gerard E. Kaiko;Stacy H. Ryu;Olivia I. Koues;Patrick L. Collins

  • Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

    Daniel L. Worthley;Michael Churchill;Jocelyn T. Compton;Yagnesh Tailor

  • Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

    Seth M. Bloom;Vinieth N. Bijanki;Gerardo M. Nava;Lulu Sun

  • Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays

    Kelli L VanDussen;Jeffrey M Marinshaw;Nurmohammad Shaikh;Hiroyuki Miyoshi

  • The microbial metabolite desaminotyrosine protects from influenza through type I interferon

    Ashley L. Steed;George P. Christophi;Gerard E. Kaiko;Lulu Sun

  • Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

    Ansuman T. Satpathy;Carlos G. Briseño;Jacob S. Lee;Dennis Ng

  • Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

    Hiroyuki Miyoshi;Rieko Ajima;Christine Tzy-Yuh Luo;Terry P. Yamaguchi

  • The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair

    Thaddeus S. Stappenbeck;Hiroyuki Miyoshi

  • Genetics and Pathogenesis of Inflammatory Bowel Disease.

    Ta-Chiang Liu;Thaddeus S. Stappenbeck

Frequent Co-Authors

Ramnik J. Xavier
Ramnik J. Xavier Broad Institute
Jeffrey I. Gordon
Jeffrey I. Gordon Washington University in St. Louis
Dermot P.B. McGovern
Dermot P.B. McGovern Cedars-Sinai Medical Center
Talin Haritunians
Talin Haritunians Cedars-Sinai Medical Center
Jason C. Mills
Jason C. Mills Baylor College of Medicine
Lora V. Hooper
Lora V. Hooper The University of Texas Southwestern Medical Center
Michael J. Holtzman
Michael J. Holtzman Washington University in St. Louis
L. David Sibley
L. David Sibley Washington University in St. Louis
Helen Piwnica-Worms
Helen Piwnica-Worms The University of Texas MD Anderson Cancer Center

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