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Genetics

D-Index
49
Citations
16423
World Ranking
3971
National Ranking
458

Overview

Matthew R. Nelson is affiliated with GlaxoSmithKline in the United Kingdom. Their research contributions span biochemistry, genetics, molecular biology, and medicine, with a particular emphasis on genetics and pharmacology.

Nelson has published extensively in fields related to genomics, rare diseases, genetic associations, pharmacogenetics, and drug metabolism. Their work also covers bioinformatics, genomic networks, statistical methods in clinical trials, health systems, economic evaluations, quality of life, and computational drug discovery methods.

Notable recent publications include:

  • "Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases" (2020, Nature Genetics)
  • "Exome sequencing and characterization of 49,960 individuals in the UK Biobank" (2020, Nature)
  • "Refining the impact of genetic evidence on clinical success" (2024, Nature)
  • "Using human genetics to improve safety assessment of therapeutics" (2022, Nature Reviews Drug Discovery)
  • "Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort" (2020, Journal of Allergy and Clinical Immunology)

Frequent co-authors include:

  • Eric Vallabh Minikel
  • Aris Floratos
  • Yufeng Shen
  • Robert A. Scott
  • John C. Whittaker

Nelson's work has appeared repeatedly in venues such as UNC Libraries, Nature, bioRxiv (Cold Spring Harbor Laboratory), Nature Genetics, and Nature Reviews Drug Discovery.

The scientist's expertise extends across several subfields, primarily:

  • Genetics
  • Pharmacology
  • Molecular Biology
  • Statistics and Probability
  • Economics and Econometrics

Best Publications

  • Genes mirror geography within Europe.

    John Novembre;Toby Johnson;Toby Johnson;Katarzyna Bryc;Zoltán Kutalik

  • The support of human genetic evidence for approved drug indications

    Matthew R Nelson;Hannah Tipney;Jeffery L Painter;Judong Shen

  • HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.

    Ann K Daly;Peter T Donaldson;Pallav Bhatnagar;Yufeng Shen

  • Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

    Mathias Ehrich;Matthew R. Nelson;Patrick Stanssens;Marc Zabeau

  • An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

    Matthew R. Nelson;Daniel Wegmann;Margaret G. Ehm;Darren Kessner

  • Correlation between genetic and geographic structure in Europe.

    Oscar Lao;Timothy T. Lu;Michael Nothnagel;Olaf Junge

  • Genome-wide patterns of population structure and admixture in West Africans and African Americans

    Katarzyna Bryc;Adam Auton;Matthew R. Nelson;Jorge R. Oksenberg

  • Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.

    Jie Zheng;Valeriia Haberland;Denis A Baird;Venexia M Walker

  • Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury is Influenced by Multiple HLA Class I and II Alleles

    M. Isabel Lucena;Mariam Molokhia;Yufeng Shen;Thomas J. Urban

  • A Combinatorial Partitioning Method to Identify Multilocus Genotypic Partitions That Predict Quantitative Trait Variation

    M.R. Nelson;S.L.R. Kardia;R.E. Ferrell;C.F. Sing

  • Exome sequencing and characterization of 49,960 individuals in the UK Biobank.

    Cristopher V Van Hout;Ioanna Tachmazidou;Ioanna Tachmazidou;Joshua D Backman;Joshua D Hoffman

  • HIBAG—HLA genotype imputation with attribute bagging

    Xiuwen Zheng;Judong Shen;Charles Cox;Jonathan C. Wakefield

  • The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research.

    Matthew R. Nelson;Katarzyna Bryc;Karen S. King;Amit Indap

  • Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

    Paola Nicoletti;Guruprasad P. Aithal;Einar S. Bjornsson;Raul J. A Andrade

  • Improved genome inference in the MHC using a population reference graph.

    Alexander Dilthey;Charles Cox;Zamin Iqbal;Matthew R Nelson

  • Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia.

    S Mah;M R Nelson;L E DeLisi;R H Reneland

  • Multi-Population Classical HLA Type Imputation

    Alexander T. Dilthey;Stephen Leslie;Loukas Moutsianas;Judong Shen

  • Global distribution of genomic diversity underscores rich complex history of continental human populations

    Adam Auton;Katarzyna Bryc;Adam R. Boyko;Kirk E. Lohmueller

  • GWASdb v2: an update database for human genetic variants identified by genome-wide association studies

    Mulin Jun Li;Zipeng Liu;Panwen Wang;Maria P. Wong

  • Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

    Jie Zheng;Valeriia Haberland;Denis Baird;Venexia Walker

Frequent Co-Authors

Ann K. Daly
Ann K. Daly Newcastle University
John C. Whittaker
John C. Whittaker Grinnell College
Munir Pirmohamed
Munir Pirmohamed University of Liverpool
Yufeng Shen
Yufeng Shen Columbia University
Guruprasad P. Aithal
Guruprasad P. Aithal University of Nottingham
John Novembre
John Novembre University of Chicago
Paul B. Watkins
Paul B. Watkins University of North Carolina at Chapel Hill
Lon R. Cardon
Lon R. Cardon The Jackson Laboratory
Charles R. Cantor
Charles R. Cantor Boston University
Gonçalo R. Abecasis
Gonçalo R. Abecasis University of Michigan–Ann Arbor

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