John C. Whittaker

Overview

Best Publications

• The support of human genetic evidence for approved drug indications

  Matthew R Nelson;Hannah Tipney;Jeffery L Painter;Judong Shen

  1418
  Citations

• Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.

  Karani S. Vimaleswaran;Diane J. Berry;Emmi Tikkanen;Emmi Tikkanen;Stefan Pilz;Stefan Pilz

  1162
  Citations

• The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

  D I Swerdlow;M V Holmes;K B Kuchenbaecker

  1116
  Citations

• Association between alcohol and cardiovascular disease:Mendelian randomisation analysis based on individual participant data

  Michael V Holmes;Michael V Holmes;Caroline E Dale;Luisa Zuccolo;Richard J Silverwood

  854
  Citations

• HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

  Daniel I Swerdlow;David Preiss;Karoline B Kuchenbaecker;Michael Holmes

  803
  Citations

• An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

  Matthew R. Nelson;Daniel Wegmann;Margaret G. Ehm;Darren Kessner

  787
  Citations

• Flintknapping: Making and Understanding Stone Tools

  John C. Whittaker

  740
  Citations

• Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

  G. Eiriksdottir;T. B. Harris;L. J. Launer;V. Gudnason

  720
  Citations

• Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

  Philippa J Talmud;Sonia Shah;Ros Whittall;Marta Futema

  688
  Citations

• Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

  Norbert Hubner;Caroline A Wallace;Heike Zimdahl;Enrico Petretto

  672
  Citations

• New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

  Shrine N;Guyatt Al;Erzurumluoglu Am;Jackson Ve;Jackson Ve;Jackson Ve

  551
  Citations

• Exome sequencing and characterization of 49,960 individuals in the UK Biobank.

  Cristopher V Van Hout;Ioanna Tachmazidou;Ioanna Tachmazidou;Joshua D Backman;Joshua D Hoffman

  439
  Citations

• Selecting instruments for Mendelian randomization in the wake of genome-wide association studies

  Daniel I Swerdlow;Karoline B Kuchenbaecker;Sonia Shah;Reecha Sofat

  436
  Citations

• Marker-assisted selection using ridge regression.

  John C. Whittaker;Robin Thompson;Mike C. Denham

  427
  Citations

• Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study

  Karani S Vimaleswaran;Karani S Vimaleswaran;Alana Cavadino;Diane J Berry;Rolf Jorde

  426
  Citations

• Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies.

  Clive J. Hoggart;John C. Whittaker;Maria De Iorio;David J. Balding

  412
  Citations

• Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.

  Michael V. Holmes;Paul Newcombe;Paul Newcombe;Jaroslav A. Hubacek;Reecha Sofat

  409
  Citations

• Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

  Karani S. Vimaleswaran;Diane J. Berry;Chen Lu;Emmi Tikkanen

  383
  Citations

• Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus

  Andrew I Russell;Deborah S Cunninghame Graham;Christopher Shepherd;Cheri A Roberton

  372
  Citations

• HMG-COENZYME A REDUCTASE INHIBITION, TYPE 2 DIABETES, AND BODYWEIGHT: EVIDENCE FROM GENETIC ANALYSIS AND RANDOMISED TRIALS

  D Swerdlow;D Preiss;A D Hingorani;N Sattar

  16
  Citations