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Biology and Biochemistry

D-Index
52
Citations
9276
World Ranking
16728
National Ranking
313

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Martin Spiess is affiliated with the University of Basel in Switzerland. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions to various subfields such as Cell Biology, Molecular Biology, Physiology, Genetics, and Epidemiology.

Their work focuses on topics related to cellular and molecular mechanisms, including:

  • Cellular transport and secretion
  • Endoplasmic Reticulum Stress and Disease
  • RNA and protein synthesis mechanisms
  • Bacterial Genetics and Biotechnology
  • Autophagy in Disease and Therapy
  • Calcium signaling and nucleotide metabolism
  • Pancreatic function and diabetes

Martin Spiess has published extensively, with frequent contributions appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Life Science Alliance, Advanced Science, Nature Chemical Biology, and Nature Cell Biology.

Recent papers include:

  • A common mechanism of Sec61 translocon inhibition by small molecules, 2023, Nature Chemical Biology
  • Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis, 2023, Nature Cell Biology
  • Shared and specific functions of Arfs 1-5 at the Golgi revealed by systematic knockouts, 2021, The Journal of Cell Biology
  • Genetic forms of neurohypophyseal diabetes insipidus, 2020, Best Practice & Research Clinical Endocrinology & Metabolism
  • Efficient integration of transmembrane domains depends on the folding properties of the upstream sequences, 2021, Proceedings of the National Academy of Sciences

Frequent collaborators in their research include Cristina Prescianotto-Baschong, Tina Junne, Mirjam Pennauer, Nicole Beuret, and Samuel Itskanov.

Martin Spiess is a member of the European Molecular Biology Organization (EMBO), reflecting recognition within the molecular biology research community.

Best Publications

  • The asialoglycoprotein receptor : a model for endocytic transport receptors

    Martin Spiess

  • The sucrase-isomaltase complex: Primary structure, membrane-orientation, and evolution of a stalked, intrinsic brush border protein

    Walter Hunziker;Walter Hunziker;Martin Spiess;Giorgio Semenza;Harvey F. Lodish

  • An internal signal sequence: the asialoglycoprotein receptor membrane anchor

    Martin Spiess;Harvey F. Lodish

  • Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion.

    M Spiess;A L Schwartz;H F Lodish

  • Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence

    Hans Peter Wessels;Martin Spiess

  • Sequence of a second human asialoglycoprotein receptor: Conservation of two receptor genes during evolution

    Martin Spiess;Harvey F. Lodish

  • Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor.

    Markus Meier;Marc D. Bider;Vladimir N. Malashkevich;Martin Spiess

  • In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting.

    R Heilker;U Manning-Krieg;J F Zuber;M Spiess

  • Distinct subcellular localization of calcium binding S100 proteins in human smooth muscle cells and their relocation in response to rises in intracellular calcium.

    A. Mandinova;D. Atar;B.W. Schafer;M. Spiess

  • Topogenesis of membrane proteins : determinants and dynamics

    Veit Goder;Martin Spiess

  • The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus

    Stephan Becker;Martin Spiess;Hans-Dieter Klenk

  • Topogenesis of membrane proteins at the endoplasmic reticulum.

    Marie Higy;Tina Junne;Martin Spiess

  • MULTIPLE DETERMINANTS DIRECT THE ORIENTATION OF SIGNAL-ANCHOR PROTEINS : THE TOPOGENIC ROLE OF THE HYDROPHOBIC SIGNAL DOMAIN

    Johanna M. Wahlberg;Martin Spiess

  • Recognition of sorting signals by clathrin adaptors.

    Ralf Heilker;Martin Spiess;Pascal Crottet

  • Endoplasmic reticulum storage diseases

    Jonas Rutishauser;Martin Spiess

  • Charged residues are major determinants of the transmembrane orientation of a signal-anchor sequence.

    J P Beltzer;K Fiedler;Christian Fuhrer;I Geffen

  • Heads or tails--what determines the orientation of proteins in the membrane.

    Martin Spiess

  • Molecular mechanism of signal sequence orientation in the endoplasmic reticulum

    Veit Goder;Martin Spiess

  • Transmembrane orientation of signal-anchor proteins is affected by the folding state but not the size of the N-terminal domain

    A. J. Denzer;C. E. Nabholz;M. Spiess

  • Expression of regulated secretory proteins is sufficient to generate granule-like structures in constitutively secreting cells.

    Nicole Beuret;Hansruedi Stettler;Anja Renold;Jonas Rutishauser

Frequent Co-Authors

Giorgio Semenza
Giorgio Semenza École Polytechnique Fédérale de Lausanne
Paul Jenö
Paul Jenö University of Basel
Helmut Hauser
Helmut Hauser University of Bristol
Luigi Mariani
Luigi Mariani University Hospital of Basel
Walter Hunziker
Walter Hunziker Agency for Science, Technology and Research
Hans Sjöström
Hans Sjöström University of Copenhagen
Kaspar H. Winterhalter
Kaspar H. Winterhalter École Polytechnique Fédérale de Lausanne
Ueli Aebi
Ueli Aebi University of Basel
Klaus Fiedler
Klaus Fiedler Heidelberg University

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