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Microbiology

D-Index
46
Citations
5408
World Ranking
4942
National Ranking
1914

Overview

Laura K. Najvar is affiliated with The University of Texas Health Science Center at San Antonio in the United States. Their research primarily spans the field of Medicine, with a focus on subfields such as Infectious Diseases, Epidemiology, Pharmacology, Microbiology, and Molecular Medicine.

Najvar's recent publications demonstrate a concentration on antifungal resistance, fungal infections, and antimicrobial activities. Key topics in their work include:

  • Antifungal resistance and susceptibility
  • Fungal Infections and Studies
  • Fungal Biology and Applications
  • Antimicrobial Peptides and Activities
  • Microbial Natural Products and Biosynthesis
  • Antibiotic Resistance in Bacteria
  • Infectious Diseases and Mycology

The scientist has contributed several recent papers, of which notable examples include:

  • "Ibrexafungerp Demonstrates In Vitro Activity against Fluconazole-Resistant Candida auris and In Vivo Efficacy with Delayed Initiation of Therapy in an Experimental Model of Invasive Candidiasis", 2021, Antimicrobial Agents and Chemotherapy
  • "Evaluation of Sex Differences in Murine Diabetic Ketoacidosis and Neutropenic Models of Invasive Mucormycosis", 2021, Journal of Fungi
  • "High-Throughput Screening of the Repurposing Hub Library to Identify Drugs with Novel Inhibitory Activity against Candida albicans and Candida auris Biofilms", 2023, Journal of Fungi
  • "Ibrexafungerp is efficacious in a neutropenic murine model of pulmonary mucormycosis as monotherapy and combined with liposomal amphotericin B", 2024, Antimicrobial Agents and Chemotherapy
  • "Screening the medicine for malaria venture's Pandemic Response Box to identify novel inhibitors of Candida albicans and Candida auris biofilm formation", 2023, Apmis

Najvar frequently publishes in journals such as:

  • Antimicrobial Agents and Chemotherapy
  • Journal of Fungi
  • Apmis
  • Preprints.org
  • Microbiology Spectrum

The scientist often collaborates with several coauthors, including:

  • Nathan P. Wiederhold
  • Thomas F. Patterson
  • Teclegiorgis Gebremariam
  • Sondus Alkhazraji
  • Scott G. Filler

The body of work by Laura K. Najvar centers on infectious disease mechanisms, antifungal pharmacology, and microbial resistance, contributing to the understanding of fungal pathogens and potential therapeutic agents. Their research involves both laboratory and experimental models to evaluate new antifungal compounds and biological activities relevant to clinical challenges in mycology.

Best Publications

  • Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

    William J. Steinbach;Robert A. Cramer;B. Zachary Perfect;Yohannes G. Asfaw

  • Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.

    Robert A. Cramer;Michael P. Gamcsik;Rhea M. Brooking;Laura K. Najvar

  • In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model.

    Qiu N. Sun;Laura K. Najvar;Rosie Bocanegra;David Loebenberg

  • Caspofungin Resistance in Candida albicans: Correlating Clinical Outcome with Laboratory Susceptibility Testing of Three Isogenic Isolates Serially Obtained from a Patient with Progressive Candida Esophagitis

    Steve Hernandez;José L. López-Ribot;Laura K. Najvar;Dora I. McCarthy

  • Antifungal Activity of Amphotericin B Cochleates against Candida albicans Infection in a Mouse Model

    Leila Zarif;John R. Graybill;David Perlin;Laura Najvar

  • Granulocyte Colony-Stimulating Factor and Azole Antifungal Therapy in Murine Aspergillosis: Role of Immune Suppression

    John R. Graybill;John R. Graybill;Rosie Bocanegra;Laura K. Najvar;David Loebenberg

  • Detection of Paracoccidioides brasiliensis in Tissue Samples by a Nested PCR Assay

    Ralf Bialek;Aida Ibricevic;Christian Aepinus;Laura K. Najvar

  • Polymerase chain reaction detection of Aspergillus DNA in experimental models of invasive aspergillosis

    Juergen Loeffler;Kerstin Kloepfer;Holger Hebart;Laura Najvar

  • In Vivo Efficacy of Anidulafungin and Caspofungin against Candida glabrata and Association with In Vitro Potency in the Presence of Sera

    Nathan P. Wiederhold;Nathan P. Wiederhold;Laura K. Najvar;Rosie Bocanegra;Destiny Molina

  • Correlation between Antifungal Susceptibilities of Coccidioides immitis In Vitro and Antifungal Treatment with Caspofungin in a Mouse Model

    Gloria M. González;Gloria M. González;Rolando Tijerina;Laura K. Najvar;Rosie Bocanegra

  • Topical Voriconazole as a Novel Treatment for Fungal Keratitis

    William Sponsel;Nancy Chen;Demi Dang;Gianmarco Paris

  • In Vitro and In Vivo Activities of Posaconazole against Coccidioides immitis

    Gloria M. González;Rolando Tijerina;Laura K. Najvar;Rosie Bocanegra

  • Treatment of Histoplasmosis with MK-991 (L-743,872)

    John R. Graybill;John R. Graybill;Laura K. Najvar;Eleanor M. Montalbo;Francesco J. Barchiesi

  • Assessment of Aspergillus fumigatus Burden in Pulmonary Tissue of Guinea Pigs by Quantitative PCR, Galactomannan Enzyme Immunoassay, and Quantitative Culture

    Ana C. Vallor;William R. Kirkpatrick;Laura K. Najvar;Rosie Bocanegra

  • Detection of Cryptococcus neoformans DNA in Tissue Samples by Nested and Real-Time PCR Assays

    Ralf Bialek;Michael Weiss;Kubrom Bekure-Nemariam;Laura K. Najvar

  • Treatment of murine disseminated candidiasis with L-743,872.

    John R. Graybill;Laura K. Najvar;Michael F. Luther;Annette W. Fothergill

  • Diagnosis and monitoring of murine histoplasmosis by a nested PCR assay.

    Ralf Bialek;Jörg Fischer;Antje Feucht;Laura K. Najvar

  • SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei").

    Hail M. Al-Abdely;Hail M. Al-Abdely;Laura Najvar;Rosie Bocanegra;Annette Fothergill

  • Interlaboratory and Interstudy Reproducibility of a Novel Lateral-Flow Device and Influence of Antifungal Therapy on Detection of Invasive Pulmonary Aspergillosis

    Nathan P. Wiederhold;Laura K. Najvar;Laura K. Najvar;Rosie Bocanegra;Rosie Bocanegra;William R. Kirkpatrick;William R. Kirkpatrick

  • Standardization of an Experimental Murine Model of Invasive Pulmonary Aspergillosis

    Donald C. Sheppard;John R. Graybill;Laura K. Najvar;Lisa Y. Chiang

Frequent Co-Authors

Nathan P. Wiederhold
Nathan P. Wiederhold The University of Texas Health Science Center at San Antonio
John R. Graybill
John R. Graybill The University of Texas Health Science Center at San Antonio
Thomas F. Patterson
Thomas F. Patterson The University of Texas Health Science Center at San Antonio
Michael G. Rinaldi
Michael G. Rinaldi The University of Texas Health Science Center at San Antonio
Annette W. Fothergill
Annette W. Fothergill The University of Texas Health Science Center at San Antonio
Brian L. Wickes
Brian L. Wickes The University of Texas Health Science Center at San Antonio
Francesco Barchiesi
Francesco Barchiesi Marche Polytechnic University
Scott G. Filler
Scott G. Filler University of California, Los Angeles
Peter C. Melby
Peter C. Melby The University of Texas Medical Branch at Galveston
Tania C. Sorrell
Tania C. Sorrell University of Sydney

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