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Immunology

D-Index
45
Citations
6922
World Ranking
4717
National Ranking
2128

Overview

Jorge C. G. Blanco is affiliated with Sigmovir Biosystems in the United States, contributing extensively to biomedical research with a primary focus on medicine and infectious diseases. Their work spans several specialized subfields, including epidemiology, immunology, neurology, and molecular biology.

The scientist's research emphasizes respiratory viral infections, viral gastroenteritis, immune response and inflammation, influenza virus studies, plant virus studies, neonatal respiratory health, and interferon and immune responses.

A selection of recent papers authored or co-authored by Jorge C. G. Blanco includes:

  • Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury, 2021, Frontiers in Immunology
  • Early or Late Bacterial Lung Infection Increases Mortality After Traumatic Brain Injury in Male Mice and Chronically Impairs Monocyte Innate Immune Function, 2020, Critical Care Medicine
  • Classical Drug Digitoxin Inhibits Influenza Cytokine Storm, With Implications for Covid-19 Therapy, 2020, In Vivo
  • A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses, 2020, The Journal of Experimental Medicine
  • Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation, 2022, Frontiers in Immunology

The frequent coauthors collaborating with Jorge C. G. Blanco include:

  • Marina S. Boukhvalova
  • Kari Ann Shirey
  • Stefanie N. Vogel
  • Arash Kamali
  • Fatoumata Y. D. Sylla

Jorge C. G. Blanco's publications appear regularly in several scientific journals, with multiple contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Scientific Reports
  • Viruses
  • Human Vaccines & Immunotherapeutics

The scholarly output of this researcher reflects a broad commitment to understanding mechanisms underlying infectious and inflammatory diseases, especially focusing on viral pathogens affecting the respiratory system and immune system dynamics.

Best Publications

  • The histone acetylase PCAF is a nuclear receptor coactivator

    Jorge C G Blanco;Saverio Minucci;Jianming Lu;Xiang Jiao Yang

  • The TLR4 antagonist Eritoran protects mice from lethal influenza infection

    Kari Ann Shirey;Wendy Lai;Alison J. Scott;Michael Lipsky

  • Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections

    Andrei E. Medvedev;Arnd Lentschat;Arnd Lentschat;Douglas B. Kuhns;Jorge C.G. Blanco

  • Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling.

    Prasad Rallabhandi;Jessica Bell;Marina S. Boukhvalova;Andrei Medvedev

  • Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children.

    Agnes A. Awomoyi;Prasad Rallabhandi;Toni I. Pollin;Eva Lorenz

  • Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R|[alpha]|-, TLR4-, and IFN-|[beta]|-dependent

    Kari Ann Shirey;Lioubov M. Pletneva;Adam C. Puche;Achsah D. Keegan

  • Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.

    J. C. G. Blanco;I-Ming Wang;S. Y. Tsai;Ming-Jer Tsai

  • Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression

    Jorge C. G. Blanco;Cristina Contursi;Cindy A. Salkowski;David L. DeWitt

  • The cotton rat provides a useful small-animal model for the study of influenza virus pathogenesis.

    Martin G. Ottolini;Jorge C. G. Blanco;Maryna C. Eichelberger;David D. Porter

  • IL-12 Is Dysregulated in Macrophages from IRF-1 and IRF-2 Knockout Mice

    Salkowski Ca;Kopydlowski K;Blanco J;Cody Mj

  • The cotton rat model of respiratory viral infections

    Marina S. Boukhvalova;Gregory A. Prince;Jorge C.G. Blanco

  • Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

    Prasad Rallabhandi;Rachel L. Phillips;Marina S. Boukhvalova;Lioubov M. Pletneva

  • Pathogenesis of human metapneumovirus lung infection in BALB/c mice and cotton rats.

    Marie-Ève Hamelin;Kevin Yim;Katie H. Kuhn;Rose P. Cragin

  • The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease.

    Marina S. Boukhvalova;Gregory A. Prince;Layla Soroush;Dolores C. Harrigan

  • TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection

    Laure Perrin-Cocon;Anne Aublin-Gex;Stefania E. Sestito;Kari Ann Shirey

  • Mutations in the 1,25-dihydroxyvitamin D3 receptor identifying C- terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with basal transcription factor IIB, in vitro

    Peter W. Jurutka;Jui Cheng Hsieh;Lenore S. Remus;G. Kerr Whitfield

  • Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton rats.

    Jorge C. G. Blanco;Joann Y. Richardson;Miriam E. R. Darnell;Anne Rowzee

  • Combination anti-inflammatory and antiviral therapy of influenza in a cotton rat model.

    Martin Ottolini;Jorge Blanco;David Porter;Lisa Peterson

  • A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation.

    Christopher C. Stobart;Christina A. Rostad;Zunlong Ke;Rebecca S. Dillard

  • Respiratory syncytial virus (RSV) infection induces cyclooxygenase 2: a potential target for RSV therapy.

    Joann Y. Richardson;Martin G. Ottolini;Lioubov Pletneva;Marina Boukhvalova

  • New Insights for Development of a Safe and Protective RSV Vaccine

    Jorge C G Blanco;Marina S Boukhvalova;Kari Ann Shirey;Gregory A Prince

Frequent Co-Authors

Stefanie N. Vogel
Stefanie N. Vogel University of Maryland, Baltimore
Gregory A. Prince
Gregory A. Prince National Institutes of Health
Keiko Ozato
Keiko Ozato Eunice Kennedy Shriver National Institute of Child Health and Human Development
Trudy G. Morrison
Trudy G. Morrison University of Massachusetts Chan Medical School
Otto Haller
Otto Haller University of Freiburg
Martin L. Moore
Martin L. Moore Emory University
Saverio Minucci
Saverio Minucci European Institute of Oncology
Moshe Arditi
Moshe Arditi Cedars-Sinai Medical Center
Christopher L. Karp
Christopher L. Karp Bill & Melinda Gates Foundation
Peter W. Jurutka
Peter W. Jurutka Arizona State University

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