World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
77
Citations
25234
World Ranking
18335
National Ranking
9150

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

John E. Nestler is affiliated with Virginia Commonwealth University in the United States and focuses their research within the field of Medicine, particularly emphasizing Reproductive Medicine and Public Health, Environmental and Occupational Health. Their scholarly output also touches on Pediatrics, Perinatology and Child Health, Endocrinology, Diabetes and Metabolism, and Nephrology.

Their published work addresses a variety of topics central to reproductive health and related biomedical areas. These topics include:

  • Ovarian function and disorders
  • Reproductive Biology and Fertility
  • Growth Hormone and Insulin-like Growth Factors
  • Renal Diseases and Glomerulopathies
  • Gestational Diabetes Research and Management
  • Ovarian cancer diagnosis and treatment
  • Assisted Reproductive Technology and Twin Pregnancy

John E. Nestler has contributed to research disseminated in several academic venues with repeated publications in:

  • Trends in Endocrinology and Metabolism
  • International Journal of Molecular Sciences
  • Expert Opinion on Drug Metabolism & Toxicology
  • Endocrine and Metabolic Science
  • The Clinical Teacher

Frequent collaborators in their research include:

  • Vittorio Unfer
  • Fabio Facchinetti
  • Christophe O. Soulage
  • Antonio Simone Laganà
  • Maria Salomè Bezerra Espinola

Their recent significant publications encompass the following works:

  • "Inositols: From Established Knowledge to Novel Approaches," 2021, International Journal of Molecular Sciences
  • "Inositols in Polycystic Ovary Syndrome: An Overview on the Advances," 2020, Trends in Endocrinology and Metabolism
  • "Experts' opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond," 2020, Expert Opinion on Drug Metabolism & Toxicology
  • "Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART)," 2020, Trends in Endocrinology and Metabolism
  • "When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments," 2024, Endocrine and Metabolic Science

In recognition of their professional standing, John E. Nestler holds membership in the Association of American Physicians.

Best Publications

  • Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*

    Harvey J. Kliman;John E. Nestler;Eduardo Sermasi;Jean M. Sanger

  • Effects of Metformin on Spontaneous and Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome

    John E. Nestler;Daniela J. Jakubowicz;William S. Evans;Renato Pasquali

  • A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome.

    John E. Nestler;Linda P. Powers;Dennis W. Matt;Kenneth A. Steingold

  • Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system.

    J E Nestler;D J Jakubowicz;A F de Vargas;C Brik

  • Effects of Metformin on Early Pregnancy Loss in the Polycystic Ovary Syndrome

    Daniela J. Jakubowicz;Maria J. Iuorno;Salomon Jakubowicz;Katherine A. Roberts

  • OVULATORY AND METABOLIC EFFECTS OF D-CHIRO-INOSITOL IN THE POLYCYSTIC OVARY SYNDROME

    John E. Nestler;Daniela J. Jakubowicz;Paula Reamer;Ronald D. Gunn

  • Dehydroepiandrosterone Reduces Serum Low Density Lipoprotein Levels and Body Fat but Does not Alter Insulin Sensitivity in Normal Men

    John E. Nestler;Cornelius O. Barlascini;John N. Clore;William G. Blackard

  • Lean Women with Polycystic Ovary Syndrome Respond to Insulin Reduction with Decreases in Ovarian P450c17α Activity and Serum Androgens1

    John E. Nestler;Daniela J. Jakubowicz

  • Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone

    David T Vandermolen;Valerie S Ratts;William S Evans;Dale W Stovall

  • Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome.

    John E. Nestler;Cornelius O. Barlascini;Dennis W. Matt;Kenneth A. Steingold

  • Association between the Current Use of Low-Dose Oral Contraceptives and Cardiovascular Arterial Disease: A Meta-Analysis

    Jean-Patrice Baillargeon;Donna K. McClish;Paulina A. Essah;John E. Nestler

  • Cardiometabolic Aspects of the Polycystic Ovary Syndrome

    Harpal S. Randeva;Bee K. Tan;Martin O. Weickert;Martin O. Weickert;Konstantinos Lois

  • Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

    M. Geoffrey Hayes;Margrit Urbanek;David A. Ehrmann;Loren L. Armstrong

  • Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome.

    John E. Nestler;Dale Stovall;Nausheen Akhter;Maria J. Iuorno

  • The Effect of Dehydroepiandrosterone Supplementation to Symptomatic Perimenopausal Women on Serum Endocrine Profiles, Lipid Parameters, and Health-Related Quality of Life

    Kurt T. Barnhart;Ellen Freeman;Jeanne Anne Grisso;Daniel J. Rader

  • A Modern Medical Quandary: Polycystic Ovary Syndrome, Insulin Resistance, and Oral Contraceptive Pills

    Evanthia Diamanti-Kandarakis;Jean-Patrice Baillargeon;Maria J. Iuorno;Daniela J. Jakubowicz

  • Total testosterone assays in women with polycystic ovary syndrome: Precision and correlation with hirsutism

    Richard S. Legro;William D. Schlaff;Michael Peter Diamond;Christos Coutifaris

  • Insulin Reduction with Metformin Increases Luteal Phase Serum Glycodelin and Insulin-Like Growth Factor-Binding Protein 1 Concentrations and Enhances Uterine Vascularity and Blood Flow in the Polycystic Ovary Syndrome

    Daniela J. Jakubowicz;Markku Seppälä;Salomon Jakubowicz;Otto Rodriguez-Armas

  • Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications

    John E. Nestler

  • The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans.

    John E. Nestler;John N. Clore;Jerome F. Strauss;William G. Blackard

Frequent Co-Authors

Richard S. Legro
Richard S. Legro Pennsylvania State University
Bruce R. Carr
Bruce R. Carr The University of Texas Southwestern Medical Center
Evan R. Myers
Evan R. Myers Duke University
Michael P. Diamond
Michael P. Diamond Augusta University
Christos Coutifaris
Christos Coutifaris University of Pennsylvania
Linda C. Giudice
Linda C. Giudice University of California, San Francisco
Evanthia Diamanti-Kandarakis
Evanthia Diamanti-Kandarakis National and Kapodistrian University of Athens
Fabio Facchinetti
Fabio Facchinetti University of Modena and Reggio Emilia
Renato Pasquali
Renato Pasquali University of Bologna
Nanette Santoro
Nanette Santoro University of Colorado Anschutz Medical Campus

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