World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
102
Citations
35775
World Ranking
1375
National Ranking
794

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ian G. Macara is affiliated with Vanderbilt University in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a strong emphasis on Molecular Biology, Oncology, Cell Biology, Genetics, and Immunology. The scientist has contributed extensively to understanding mechanisms at the cellular and molecular levels across these areas.

The main topics covered in their body of work include:

  • Cancer Cells and Metastasis
  • Cellular transport and secretion
  • Pluripotent Stem Cells Research
  • CRISPR and Genetic Engineering
  • RNA Research and Splicing
  • Developmental Biology and Gene Regulation
  • Single-cell and spatial transcriptomics

Their frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cell Biology
  • Developmental Cell
  • UNC Libraries
  • Nature

Selected recent papers authored or co-authored by Ian G. Macara are:

  • "Mutations in the exocyst component EXOC2 cause severe defects in human brain development," 2020, The Journal of Experimental Medicine
  • "Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells," 2022, Nature Cell Biology
  • "DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation," 2020, Developmental Cell
  • "Temporal recording of mammalian development and precancer," 2024, Nature
  • "Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation," 2020, eLife

Frequent co-authors collaborating with Ian G. Macara include:

  • Paola Molina
  • Ken S. Lau
  • Christian de Caestecker
  • Mirazul Islam
  • Yilin Yang

In recognition of their contributions, Ian G. Macara was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2017.

Best Publications

  • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

    Rui Yi;Yi Qin;Ian G. Macara;Bryan R. Cullen

  • Transport into and out of the Nucleus

    Ian G. Macara

  • The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.

    Gérard Joberty;Clark Petersen;Lin Gao;Ian G. Macara

  • The PAR Proteins: Fundamental Players in Animal Cell Polarization

    Bob Goldstein;Ian G. Macara

  • Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

    Shian Huey Chiang;Christian A. Baumann;Christian A. Baumann;Makoto Kanzaki;Debbie C. Thurmond

  • Organization and execution of the epithelial polarity programme

    Enrique Rodriguez-Boulan;Ian G. Macara

  • Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex

    Enrico Brugnera;Lisa Haney;Cynthia Grimsley;Mingjian Lu

  • CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.

    Tina L. Gumienny;Tina L. Gumienny;Enrico Brugnera;Annie-Carole Tosello-Trampont;Jason M. Kinchen;Jason M. Kinchen

  • Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.

    Toby W. Hurd;Lin Gao;Michael H. Roh;Ian G. Macara

  • Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.

    Xinyu Chen;Ian G. Macara

  • Structural insight into filament formation by mammalian septins

    Minhajuddin Sirajuddin;Marian Farkasovsky;Florian Hauer;Dorothee Kühlmann

  • Mammalian Pins Is a Conformational Switch that Links NuMA to Heterotrimeric G Proteins

    Quansheng Du;Ian G. Macara

  • Vanadium — an element in search of a role

    Ian G. Macara

  • Parsing the Polarity Code

    Ian G. Macara

  • Inhibition of Nuclear Import by Protein Kinase B (Akt) Regulates the Subcellular Distribution and Activity of the Forkhead Transcription Factor AFX

    Amy M. Brownawell;Geert J. P. L. Kops;Ian G. Macara;Boudewijn M. T. Burgering

  • Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis

    I G Macara;G V Marinetti;P C Balduzzi

  • Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

    Alan Wolfman;Ian G. Macara

  • Overexpression of Exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs

    Rui Yi;Brian P. Doehle;Yi Qin;Ian G. Macara

  • Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications

    Ian G. Macara;Kenneth Kustin;Lewis C. Cantley

  • Quantitative cell biology with the Virtual Cell.

    Boris M. Slepchenko;James C. Schaff;Ian Macara;Leslie M. Loew

Frequent Co-Authors

Donald F. Hunt
Donald F. Hunt University of Virginia
Jeffrey Shabanowitz
Jeffrey Shabanowitz University of Virginia
Lewis C. Cantley
Lewis C. Cantley Harvard University
Robert Levenson
Robert Levenson Pennsylvania State University
Timothy A. J. Haystead
Timothy A. J. Haystead Duke University
W. Hayes McDonald
W. Hayes McDonald Vanderbilt University
Kenneth Kustin
Kenneth Kustin Brandeis University
Alan R. Saltiel
Alan R. Saltiel University of California, San Diego
Makoto Kinoshita
Makoto Kinoshita University of Tokushima

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