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D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
26227
World Ranking
3662
National Ranking
1823

Overview

Ben Margolis is affiliated with the University of Michigan-Ann Arbor in the United States. Their research focuses primarily on the fields of Biochemistry, Genetics and Molecular Biology, with particular emphasis on Cell Biology and Molecular Biology.

Their recent publications include studies on epithelial cell biology and cytoskeletal dynamics. Notable papers are:

  • ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture (2020, UNC Libraries)
  • Crb3 and NF2: A dynamic duo that controls assembly of the apical junctions and barrier function via Rho/ROCK signaling (2025, bioRxiv (Cold Spring Harbor Laboratory))
  • CRB3 and NF2 orchestrate cytoskeletal dynamics to control epithelial barrier assembly (2025, JCI Insight)

Frequent collaborators include:

  • Shuling Fan
  • Saranyaraajan Varadarajan
  • Vicky García-Hernández
  • Charles A. Parkos
  • Matthew A. Odenwald

Ben Margolis publishes predominantly in venues such as UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), and JCI Insight.

Their research spans several main topics, including:

  • Hippo pathway signaling and YAP/TAZ
  • Connexins and lens biology
  • Protein Kinase Regulation and GTPase Signaling
  • Microtubule and mitosis dynamics
  • Cellular transport and secretion
  • Endoplasmic Reticulum Stress and Disease

Best Publications

  • The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

    E.J. Lowenstein;R.J. Daly;A.G. Batzer;W. Li

  • Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.

    N. Li;A. Batzer;R. Daly;V. Yajnik

  • Tight Junctions and Cell Polarity

    Kunyoo Shin;Vanessa C. Fogg;Ben Margolis

  • Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

    E.Y. Skolnik;B. Margolis;M. Mohammadi;E. Lowenstein

  • EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.

    B. Margolis;S.G. Rhee;S. Felder;M. Mervic

  • The function of GRB2 in linking the insulin receptor to ras signaling pathways

    EY Skolnik;A Batzer;N Li;CH Lee

  • Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.

    Kristen J. Verhey;Debra Meyer;Reneé Deehan;John Blenis

  • The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

    Jean Paul Borg;James Ooi;Efrat Levy;Ben Margolis

  • A Drosophila SH2-SH3 Adaptor Protein Implicated in Coupling the Sevenless Tyrosine Kinase to an Activator of Ras Guanine Nucleotide Exchange, Sos

    Jean Paul Olivier;Thomas Raabe;Mark Henkemeyer;Barry Dickson

  • Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.

    Toby W. Hurd;Lin Gao;Michael H. Roh;Ian G. Macara

  • Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling

    David A. Calderwood;Yosuke Fujioka;Jose M. de Pereda;Begoña García-Alvarez

  • The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost

    Michael H. Roh;Olga Makarova;Chia Jen Liu;Kunyoo Shin

  • Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin

    Edgar A. Otto;Bart Loeys;Hemant Khanna;Jan Hellemans

  • Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.

    P Hu;B Margolis;E Y Skolnik;R Lammers

  • The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

    B. Margolis;N. Li;A. Koch;M. Mohammadi

  • SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.

    D. Rotin;B. Margolis;M. Mohammadi;R.J. Daly

  • ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor

    Jean Paul Borg;Sylvie Marchetto;André Le Bivic;Vincent Ollendorff

  • A Size-Exclusion Permeability Barrier and Nucleoporins Characterize a Ciliary Pore Complex that Regulates Transport into Cilia

    Hooi Lynn Kee;John F. Dishinger;T. Lynne Blasius;Chia Jen Liu

  • Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.

    John F. Dishinger;Hooi Lynn Kee;Paul M. Jenkins;Shuling Fan

  • The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells

    Michael H. Roh;Shuling Fan;Chia Jen Liu;Ben Margolis;Ben Margolis

Frequent Co-Authors

Anand Swaroop
Anand Swaroop National Institutes of Health
Deborah L. Gumucio
Deborah L. Gumucio University of Michigan–Ann Arbor
R. Scott Turner
R. Scott Turner Georgetown University
Jerrold R. Turner
Jerrold R. Turner Brigham and Women's Hospital
David S. Williams
David S. Williams University of California, Los Angeles
Alan F. Wright
Alan F. Wright University of Edinburgh
Peer Bork
Peer Bork European Molecular Biology Laboratory
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital

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