World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
93
Citations
30149
World Ranking
10934
National Ranking
343

Overview

Iain J. Clarke is affiliated with the University of Melbourne in Australia and has a research focus primarily within the fields of Medicine and Agricultural and Biological Sciences. Their work often intersects with several subfields, including Animal Science and Zoology, Reproductive Medicine, Insect Science, Endocrine and Autonomic Systems, and Physiology.

The scientist's research covers multiple main topics, notably:

  • Effects of Environmental Stressors on Livestock
  • Meat and Animal Product Quality
  • Hypothalamic Control of Reproductive Hormones
  • Regulation of Appetite and Obesity
  • Adipose Tissue and Metabolism
  • Ovarian Function and Disorders
  • Reproductive Physiology in Livestock

Their extensive publication record includes contributions to a variety of journals, with frequent appearances in the following venues:

  • Animals
  • Journal of Endocrinology
  • Journal of Animal Science
  • Molecular Metabolism
  • Animal Frontiers

Representative recent papers authored or co-authored by Clarke include:

  • "Resilience of Small Ruminants to Climate Change and Increased Environmental Temperature: A Review" (2020, Animals)
  • "The melanocortin pathway and energy homeostasis: From discovery to obesity therapy" (2021, Molecular Metabolism)
  • "Effect of sex and sex steroids on brown adipose tissue heat production in humans" (2020, European Journal of Endocrinology)
  • "Impact of heat stress on ruminant livestock production and meat quality, and strategies for amelioration" (2023, Animal Frontiers)
  • "Comparative Assessment of Thermotolerance in Dorper and Second-Cross (Poll Dorset/Merino × Border Leicester) Lambs" (2020, Animals)

Frequent collaborators in Clarke's research include:

  • Frank R. Dunshea
  • Surinder S. Chauhan
  • B. J. Leury
  • Kristy DiGiacomo
  • Belinda A. Henry

Best Publications

  • The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes.

    Iain J. Clarke;James T. Cummins

  • Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.

    Robert L Goodman;Michael N Lehman;Jeremy Troy Smith;Lique M Coolen

  • Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences

    Alan J Tilbrook;Anne I Turner;Iain J Clarke

  • KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season.

    Jeremy Troy Smith;Colin Clay;Alain Caraty;Iain James Clarke

  • Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

    Antonia K Roseweir;Alexander S Kauffman;Jeremy Troy Smith;Kathryn A Guerriero

  • Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion

    Iain James Clarke;Ika Puspita Sari;Yue Qi;Jeremy Troy Smith

  • Photoperiodically-induced cycles in the secretion of prolactin in hypothalamo-pituitary disconnected rams: evidence for translation of the melatonin signal in the pituitary gland.

    G. A. Lincoln;I. J. Clarke

  • Variation in Kisspeptin and RFamide-Related Peptide (RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep

    Jeremy T. Smith;Lique M. Coolen;Lance J. Kriegsfeld;Ika P. Sari

  • Kisspeptin Synchronizes Preovulatory Surges in Cyclical Ewes and Causes Ovulation in Seasonally Acyclic Ewes

    Alain Caraty;Jeremy Troy Smith;D Lomet;S Ben Said

  • Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells

    Kathryn Backholer;Jeremy Troy Smith;Alexandra Rao;Alda Pereira

  • Steroid feedback inhibition of pulsatile secretion of gonadotropin-releasing hormone in the ewe.

    Fred J. Karsch;James T. Cummins;Gregory B. Thomas;Iain J. Clarke

  • Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function.

    Belinda A. Henry;James W. Goding;Warren S. Alexander;Alan J. Tilbrook

  • Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia.

    Dennis Engler;Thao Pham;Meryl J. Fullerton;Guck Ooi

  • Characterizing a Mammalian Circannual Pacemaker

    Gerald A Lincoln;Iain James Clarke;Roelof A Hut;David G Hazlerigg

  • Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence

    Jeremy T Smith;Qun Li;Kai Sing Yap;Muhammad Shahab

  • Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback.

    Karla Estrada;Colin Clay;Sueli Pompolo;Jeremy Troy Smith

  • Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo.

    Jeremy Troy Smith;Alexandra Rao;Alda Pereira;Alain Caraty

  • Pituitary Gland Function after Disconnection from Direct Hypothalamic Influences in the Sheep

    Iain James Clarke;James Thomas Cummins;James Thomas Cummins;David Morritz de Kretser

  • Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. Spontaneous secretion and response to insulin-induced hypoglycemia.

    L A Frohman;T R Downs;I J Clarke;G B Thomas

  • Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge.

    Jeremy Troy Smith;Qun Li;Alda Pereira;Iain James Clarke

Frequent Co-Authors

Frank R. Dunshea
Frank R. Dunshea University of Melbourne
John W. Funder
John W. Funder Hudson Institute of Medical Research
Jock K. Findlay
Jock K. Findlay Hudson Institute of Medical Research
Robert P. Millar
Robert P. Millar University of Pretoria
David Robertson
David Robertson Vanderbilt University
Fred J. Karsch
Fred J. Karsch University of Michigan–Ann Arbor
D. M. de Kretser
D. M. de Kretser Monash University
Gavin W. Lambert
Gavin W. Lambert Swinburne University of Technology
Brian J. Leury
Brian J. Leury University of Melbourne
Brian J. Oldfield
Brian J. Oldfield Monash University

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