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Geert Leroux-Roels

Geert Leroux-Roels

D-Index & Metrics

Immunology

D-Index
80
Citations
20761
World Ranking
1644
National Ranking
22

Overview

Geert Leroux-Roels is affiliated with Ghent University in Belgium. Their research spans major areas of Medicine and Immunology and Microbiology, contributing extensively to epidemiology, infectious diseases, immunology, hepatology, and public health disciplines.

The scientist's work involves significant exploration into viral infections and vaccination strategies. Primary research topics include:

  • Influenza Virus Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Hepatitis B Virus Studies
  • Hepatitis C virus research
  • Respiratory viral infections research
  • Viral gastroenteritis research and epidemiology
  • Animal Virus Infections Studies

Frequent publication venues reflect a focus on immunology and vaccine-related research. These include:

  • Frontiers in Immunology
  • Vaccine
  • The Lancet Infectious Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Vaccine X

Among recent papers by Geert Leroux-Roels are:

  • Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial, 2021, Vaccine
  • Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2, 2021, Wiener klinische Wochenschrift
  • Phase 1 Assessment of the Safety and Immunogenicity of an mRNA- Lipid Nanoparticle Vaccine Candidate Against SARS-CoV-2 in Human Volunteers, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in healthy adults: two clinical trials, 2020, The Lancet
  • Immunogenicity and safety of a tri-antigenic versus a mono-antigenic hepatitis B vaccine in adults (PROTECT): a randomised, double-blind, phase 3 trial, 2021, The Lancet Infectious Diseases

Common collaborators include:

  • Isabel Leroux-Roels
  • Gwenn Waerlop
  • Pierre Van Damme
  • Lidia Oostvogels
  • Gianluca Quintini

This researcher's profile demonstrates ongoing work in developing and testing vaccines, especially involving mRNA technology and lipid nanoparticle delivery systems, with an emphasis on prophylactic measures against viral diseases such as rabies, SARS-CoV-2, poliovirus, and hepatitis B.

Best Publications

  • Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial.

    Isabel Leroux-Roels;Astrid Borkowski;Thomas Vanwolleghem;Mamadou Dramé

  • Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro

    Brett D. Lindenbach;Philip Meuleman;Alexander Ploss;Thomas Vanwolleghem

  • Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.

    Hélène Quach;Maxime Rotival;Maxime Rotival;Julien Pothlichet;Julien Pothlichet;Yong-Hwee Eddie Loh;Yong-Hwee Eddie Loh

  • Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera.

    Philip Meuleman;Louis Libbrecht;Rita De Vos;Bernard de Hemptinne

  • Unmet needs in modern vaccinology: Adjuvants to improve the immune response

    Geert Leroux-Roels

  • Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo.

    Philip Meuleman;Joseph Hesselgesser;Matthew Paulson;Thomas Vanwolleghem

  • Respiratory Syncytial Virus and Other Respiratory Viral Infections in Older Adults With Moderate to Severe Influenza-like Illness

    Ann R. Falsey;Janet E. McElhaney;Jiri Beran;Gerrit A. van Essen

  • Vaccine adjuvant systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers.

    Pierre Vandepapelière;Yves Horsmans;Philippe Moris;Marcelle Van Mechelen

  • Hepatitis A booster vaccination: is there a need?

    Pierre Van Damme;J Banatvala;O Fay;S Iwarson

  • Vaccine- and hepatitis B immune globulin-induced escape mutations of hepatitis B virus surface antigen.

    Michael P. Cooreman;Geert Leroux-Roels;Wilma P. Paulij

  • Line Probe Assay for Monitoring Drug Resistance in Hepatitis B Virus-Infected Patients during Antiviral Therapy

    Lieven Stuyver;Caroline Van Geyt;Sija De Gendt;Georges Van Reybroeck

  • Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: a randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudine.

    Pierre Vandepapelière;George K K Lau;Geert Leroux-Roels;Yves Horsmans

  • Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant

    Artur Kaul;Ilka Woerz;Philip Meuleman;Geert Leroux-Roels

  • Broad Clade 2 cross-reactive immunity induced by an adjuvanted clade 1 rH5N1 pandemic influenza vaccine.

    Isabel Leroux-Roels;Roger Bernhard;Pascal Gérard;Mamadou Dramé

  • Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system

    S Thoelen;P Van Damme;C Mathei;Geert Leroux-Roels

  • Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity

    Joe Grove;Thierry Huby;Zania Stamataki;Thomas Vanwolleghem

  • Hepatitis B virus and human immunodeficiency virus co-infection in sub-Saharan Africa: a call for further investigation.

    R J Burnett;G François;M C Kew;G Leroux-Roels

  • Priming with AS03A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: an open non-randomised extension of a double-blind randomised primary study.

    Isabel Leroux-Roels;François Roman;Sheron Forgus;Cathy Maes

  • Improved CD4+ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: A randomized trial

    Isabel Leroux-Roels;Sheron Forgus;Fien De Boever;Frédéric Clement

  • Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain.

    Thomas Vanwolleghem;Jens Bukh;Jens Bukh;Jens Bukh;Philip Meuleman;Isabelle Desombere

Frequent Co-Authors

Philip Meuleman
Philip Meuleman Ghent University
Joris R. Delanghe
Joris R. Delanghe Ghent University
Geert Maertens
Geert Maertens Biocartis (Belgium)
Jonathan K. Ball
Jonathan K. Ball University of Nottingham
Jens Bukh
Jens Bukh University of Copenhagen
Thomas F. Baumert
Thomas F. Baumert University of Strasbourg
Tania Roskams
Tania Roskams KU Leuven
Robert W. Sauerwein
Robert W. Sauerwein Radboud University
Riccardo Cortese
Riccardo Cortese Schering-Plough
Alfredo Nicosia
Alfredo Nicosia University of Naples Federico II

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