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Microbiology

D-Index
48
Citations
7447
World Ranking
4708
National Ranking
137

Overview

Earl G. Brown is affiliated with the University of Ottawa in Canada. Their research spans multiple fields, primarily focused on Medicine and Biochemistry, Genetics and Molecular Biology.

Brown's work involves several subfields, including Molecular Biology, Oncology, Biomedical Engineering, Neurology, and Pulmonary and Respiratory Medicine. The main topics of their research cover RNA regulation and disease, Cancer Cells and Metastasis, 3D Printing in Biomedical Research, Respiratory Support and Mechanisms, Animal Testing and Alternatives, the Delphi Technique in Research, and Cancer, Hypoxia, and Metabolism.

The following papers illustrate the scope and diversity of their recent research output:

  • "Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians," 2020, published in Critical Care Medicine
  • "Generation and Evaluation of Hydrogel-Facilitated 3D Tumor Microenvironments of Breast Cancer," 2022, published in Nano LIFE
  • "Erratum: Generation and Evaluation of Hydrogel-Facilitated 3D Tumor Microenvironments of Breast Cancer," 2023, published in Nano LIFE
  • "Variants in Lrrk2 and Snca deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn mice," 2024, published in bioRxiv (Cold Spring Harbor Laboratory)
  • "A Protocol for Neuralized Murine Olfactory Organoids," 2024, published in bioRxiv (Cold Spring Harbor Laboratory)

Brown has frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nano LIFE, Critical Care Medicine, and PLoS ONE. Their most frequent publication venue is bioRxiv, with three papers published there, followed by two papers in Nano LIFE.

Collaborations are an important aspect of Brown's research. Frequent co-authors include:

  • Julianna J. Tomlinson
  • Michael G. Schlossmacher
  • Michaela Lunn
  • Sheba Goklany
  • Lauryn De La Torre

Best Publications

  • VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

    David F Stojdl;Brian D Lichty;Benjamin R tenOever;Jennifer M Paterson

  • Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells

    Aida Ibricevic;Andrew Pekosz;Michael J. Walter;Celeste Newby

  • Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

    Ninan Abraham;David F. Stojdl;Peter I. Duncan;Nathalie Méthot

  • Influenza Infection Leads to Increased Susceptibility to Subsequent Bacterial Superinfection by Impairing NK Cell Responses in the Lung

    Cherrie-Lee Small;Christopher R. Shaler;Sarah McCormick;Mangalakumari Jeyanathan

  • The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus

    David F. Stojdl;Ninan Abraham;Shane Knowles;Ricardo Marius

  • Antigenic and genetic characterization of H9N2 swine influenza viruses in China.

    Yan L. Cong;Juan Pu;Qin F. Liu;Shuai Wang

  • Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing

    Mohammed Selman;Samar K Dankar;Nicole E Forbes;Jian-Jun Jia

  • Quantitative Proteomic Analyses of Influenza Virus-Infected Cultured Human Lung Cells

    Kevin M. Coombs;Alicia Berard;Wanhong Xu;Oleg Krokhin

  • Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3.

    L. A. Schiff;M. L. Nibert;Man Sung Co;E. G. Brown

  • Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008.

    Yipeng Sun;Juan Pu;Zhanlei Jiang;Tao Guan

  • Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

    Barbara Herdy;Maritza Jaramillo;Yuri V Svitkin;Amy B Rosenfeld

  • Cigarette smoke impacts immune inflammatory responses to influenza in mice.

    Clinton S. Robbins;Carla M. T. Bauer;Neda Vujicic;Gordon J. Gaschler

  • Negative Regulation of Lung Inflammation and Immunopathology by TNF-α during Acute Influenza Infection

    Daniela Damjanovic;Maziar Divangahi;Kapilan Kugathasan;Cherrie-Lee Small

  • Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem

    C. A. Thomson;Y. Wang;L. M. Jackson;M. Olson

  • The influenza virus variant A/FM/1/47-MA possesses single amino acid replacements in the hemagglutinin, controlling virulence, and in the matrix protein, controlling virulence as well as growth.

    C A Smeenk;E G Brown

  • Universal anti-neuraminidase antibody inhibiting all influenza A subtypes.

    Tracey M. Doyle;Anwar M. Hashem;Anwar M. Hashem;Changgui Li;Gary Van Domselaar

  • Reovirus ςNS Protein Is Required for Nucleation of Viral Assembly Complexes and Formation of Viral Inclusions

    Michelle M. Becker;Mehmet I. Goral;Paul R. Hazelton;Geoffrey S. Baer

  • Experimental Evolution of Human Influenza Virus H3 Hemagglutinin in the Mouse Lung Identifies Adaptive Regions in HA1 and HA2

    Liya Keleta;Aida Ibricevic;Nicolai V. Bovin;Steven L. Brody

  • Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection.

    Carla M. T. Bauer;Caleb C. J. Zavitz;Fernando M. Botelho;Kristen N. Lambert

  • Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

    Jihui Ping;Liya Keleta;Liya Keleta;Nicole E. Forbes;Nicole E. Forbes;Samar Dankar;Samar Dankar

  • Responses in the Lung Superinfection by Impairing NK Cell Susceptibility to Subsequent Bacterial Influenza Infection Leads to Increased

    Charu Kaushic;Ali A. Ashkar;Zhou Xing Damjanovic;Earl G. Brown

Frequent Co-Authors

Brian D. Lichty
Brian D. Lichty McMaster University
Nahum Sonenberg
Nahum Sonenberg McGill University
Gary Van Domselaar
Gary Van Domselaar Public Health Agency of Canada
Martin R. Stämpfli
Martin R. Stämpfli McMaster University
Eleanor N. Fish
Eleanor N. Fish University of Toronto
John C. Bell
John C. Bell University of Ottawa
Zhou Xing
Zhou Xing McMaster University
Aeron C. Hurt
Aeron C. Hurt Roche (Switzerland)
Karen L. Mossman
Karen L. Mossman McMaster University
Ali A. Ashkar
Ali A. Ashkar McMaster University

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